VDR/NR1I1/Vitamin D Receptor Antibody (8C356)

VDR/NR1I1/Vitamin D Receptor Antibody (8C356) [NBP1-94706] - Analysis of immunized recombinant protein using anti-VDR antibody. Arrow indicates region of immunized recombinant protein carrying 50-200 amino acids.

Product Discontinued

VDR/NR1I1/Vitamin D Receptor Antibody (8C356) Summary

• Immunogen: Partial recombinant sequence from human Vitamin D Receptor
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: VDR
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Dot Blot 1:100-1:2000
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4) and 1.0% BSA
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for VDR/NR1I1/Vitamin D Receptor Antibody (8C356)

• NR1I1
• NR1I1Nuclear receptor subfamily 1 group I member 11,25-dihydroxyvitamin D3 receptor
• VDR
• vitamin D1,25- dihydroxyvitamin D3 receptor
• vitamin D3 receptor

Background

Vitamin D Receptor encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for VDR/NR1I1/Vitamin D Receptor Antibody (NBP1-94706)(1)

Publication using NBP1-94706

• Momen-Heravi F, Masugi Y, Qian ZR et al. Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study Int. J. Cancer 2017-08-30 [PMID: 28856682] (Human)

Bioinformatics

• Gene Symbol: VDR