VCAM-1/CD106 Antibody (MR106) [Biotin]

Images

 
Flow Cytometry: VCAM-1/CD106 Antibody (MR106) [Biotin] [NBP1-43597] - Staining of rat bone marrow cells with 0.125 ug of Mouse IgG1 kappa Isotype Control Biotin (left) or 0.125 ug of Anti-Rat CD106 (VCAM-1) Biotin ...read more

Product Details

Summary
Reactivity RtSpecies Glossary
Applications Flow
Clone
MR106
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin
Concentration
0.5 mg/ml

VCAM-1/CD106 Antibody (MR106) [Biotin] Summary

Immunogen
The immunogen for this antibody was CD106.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
VCAM1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
This MR106 antibody has been tested by flow cytometric analysis of rat bone marrow cells. This can be used at less than or equal to 0.5 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test.
Readout System

Reactivity Notes

This antibody is reactive to Rat.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS, pH 7.2, with 0.1% gelatin
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for VCAM-1/CD106 Antibody (MR106) [Biotin]

  • CD106 antigen
  • CD106
  • DKFZp779G2333
  • INCAM-100
  • L1CAM
  • MGC99561
  • vascular cell adhesion molecule 1
  • vascular cell adhesion protein 1
  • V-CAM 1
  • VCAM1
  • VCAM-1

Background

The MR106 monoclonal antibody reacts with rat CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110 kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and further upregulate VCAM-1 upon cytokine stimulation. CD106 binds to integrin alpha4beta1 (VLA-4, CD49d/CD29) and Integrin alpha4beta7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for VCAM-1/CD106 Antibody (NBP1-43597)

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Bioinformatics

Gene Symbol VCAM1
Entrez