USP20 Antibody [HRP]

• Reactivity: Hu, Mu
• Applications: WB, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: HRP

USP20 Antibody [HRP] Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residue 863 and 913 of human ubiquitin specific peptidase 20 (pVHL-interacting deubiquitinating enzyme 2) using the numbering given in entry NP_006667.2 (GeneID 10868).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: USP20
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for USP20 Antibody [HRP]

• Deubiquitinating enzyme 20
• EC 3.4.19.12
• KIAA1003hVDU2
• LSFR3A
• pVHL-interacting deubiquitinating enzyme 2
• ubiquitin carboxyl-terminal hydrolase 20
• ubiquitin specific peptidase 20
• ubiquitin specific protease 20
• ubiquitin thioesterase 20
• Ubiquitin Thiolesterase 20
• Ubiquitin-specific-processing protease 20
• USP20
• VDU2
• VHL-interacting deubiquitinating enzyme 2

Background

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: USP20