TSG-6 Antibody (259820) [Janelia Fluor® 669]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 259820
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

TSG-6 Antibody (259820) [Janelia Fluor® 669] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human TSG-6
  Trp18-Leu277
  Accession # P98066
• Specificity: Detects human and mouse TSG-6 in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: TNFAIP6
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for TSG-6 Antibody (259820) [Janelia Fluor® 669]

• Hyaluronate-binding protein
• TNF alpha-induced protein 6
• TNFAIP6
• TNF-stimulated gene 6 protein
• TSG6
• TSG-6
• TSG-6tumor necrosis factor alpha-inducible protein 6
• TSG6tumor necrosis factor-inducible gene 6 protein
• Tumor necrosis factor alpha-induced protein 6
• tumor necrosis factor, alpha-induced protein 6
• tumor necrosis factor-stimulated gene-6 protein

Background

TSG6 is encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. The expression of this gene can be induced by tumor necrosis factor alpha and interleukin-1. The expression can also be induced by mechanical stimuli in vascular smooth muscle cells, and is found to be correlated with proteoglycan synthesis and aggregation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNFAIP6