TSG-6 Products

Description

TSG6 is encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. The expression of this gene can be induced by tumor necrosis factor alpha and interleukin-1. The expression can also be induced by mechanical stimuli in vascular smooth muscle cells, and is found to be correlated with proteoglycan synthesis and aggregation.

Bioinformatics

Entrez	21930 Mouse 7130 Human
Uniprot	AAH30205 Human NM_007115 Human NP_009046.2 Human P98066 Human
Product By Gene ID	7130
Alternate Names	Hyaluronate-binding protein TNF alpha-induced protein 6 TNF-stimulated gene 6 protein TSG-6tumor necrosis factor alpha-inducible protein 6 TSG6tumor necrosis factor-inducible gene 6 protein Tumor necrosis factor alpha-induced protein 6 tumor necrosis factor, alpha-induced protein 6 tumor necrosis factor-stimulated gene-6 protein