Human Pentraxin 3/TSG-14 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Pentraxin 3/TSG-14 DuoSet ELISA, 15 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: PTX3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Pentraxin 3/TSG-14 DuoSet ELISA, 15 Plate

• alpha-induced protein 5
• pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor
• Pentaxin-related protein PTX3
• Pentraxin 3
• pentraxin 3, long
• pentraxin-3
• pentraxin-related gene, rapidly induced by IL-1 beta
• pentraxin-related protein PTX3
• PTX3
• TNF alpha-induced protein 5
• TNFAIP5
• TSG14
• TSG-14
• TSG-14pentaxin-related gene, rapidly induced by IL-1 beta
• Tumor necrosis factor alpha-induced protein 5
• tumor necrosis factor, alpha-induced protein 5
• Tumor necrosis factor-inducible gene 14 protein
• tumor necrosis factor-inducible protein TSG-14

Background

Pentraxin 3 (PTX3), also known as TNF-stimulated gene 14 (TSG-14), is a secreted glycoprotein belonging to the Pentraxin family of proteins. It is the prototypical long Pentraxin, exhibiting a C-terminal Pentraxin domain characteristic of the family, and a unique N-terminal domain. It is produced by several cell types including endothelial and mononuclear cells. PTX3 acts as a pattern recognition receptor with non-redundant roles in the innate immune response to several microbial agents including the fungal pathogen Aspergillus fumigatus. Overexpression leads to enhanced pro-inflammatory responses. PTX3 is induced in response to LPS and inflammatory cytokines including TNF-alpha and IL-1 beta.

Publications for Pentraxin 3/TSG-14 (DY1826)(12)

Publications using DY1826

• KN Lee, KH Park, YM Kim, I Cho, TE Kim Prediction of emergency cerclage outcomes in women with cervical insufficiency: The role of inflammatory, angiogenic, and extracellular matrix-related proteins in amniotic fluid PLoS ONE, 2022;17(5):e0268291. 2022 [PMID: 35536791] (Human)
• N Hwang, MY Kwon, JM Woo, SW Chung Oxidative Stress-Induced Pentraxin 3 Expression Human Retinal Pigment Epithelial Cells is Involved in the Pathogenesis of Age-Related Macular Degeneration Int J Mol Sci, 2019;20(23):. 2019 [PMID: 31795454] (Human)
• ME O'Brien, D Chandra, RC Wilson, CM Karoleski, CR Fuhrman, JK Leader, J Pu, Y Zhang, A Morris, S Nouraie, J Bon, Z Urban, FC Sciurba Loss of skin elasticity is associated with pulmonary emphysema, biomarkers of inflammation, and matrix metalloproteinase activity in smokers Respir. Res., 2019;20(1):128. 2019 [PMID: 31234847] (Human)
• K Bendí?ková, F Tidu, M De Zuani, MH Kohoutková, I Andrej?ino, A Pompeiano, S B?lášková, G Forte, T Zelante, J Fri? Calcineurin inhibitors reduce NFAT-dependent expression of antifungal pentraxin-3 by human monocytes J. Leukoc. Biol., 2019;0(0):. 2019 [PMID: 30934147] (Human)
• NV Batista, M Barbagallo, VLS Oliveira, T Castro-Gom, RDR Oliveira, P Louzada-Ju, GRC Pinheiro, A Mantovani, MM Teixeira, C Garlanda, FA Amaral The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals J. Immunol., 2019;0(0):. 2019 [PMID: 30718300] (Human)
• V Ciancarell, L Lembo-Fazi, I Paciello, AK Bruno, S Jaillon, S Berardi, M Barbagallo, S Meron-Suda, D Cohen, A Molinaro, G Rossi, C Garlanda, ML Bernardini Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection PLoS Pathog., 2018;14(12):e1007469. 2018 [PMID: 30532257] (Human)
• T Akhter, AK Wikström, M Larsson, A Larsson, G Wikström, T Naessen Serum Pentraxin 3 is associated with signs of arterial alteration in women with preeclampsia Int. J. Cardiol., 2017;0(0):. 2017 [PMID: 28377191] (Human)
• Narae Hwang Tunicamycin-induced Endoplasmic Reticulum Stress Upregulates the Expression of Pentraxin 3 in Human Retinal Pigment Epithelial Cells Korean J Ophthalmol, 2016;30(6):468-478. 2016 [PMID: 27980366] (Human)
• Foo , Suan-Sin, Chen , Weiqiang, Taylor , Adam, Sheng , Kuo-Chin, Yu , Xing, Teng , Terk-Shi, Reading , Patrick, Blanchard , Helen, Garlanda , Cecilia, Mantovani , Alberto, Ng , Lisa F P, Herrero , Lara J, Mahalingam , Suresh Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation. PLoS Pathog, 2015;11(2):e1004649. 2015 [PMID: 25695775] (Human)
• Ketter P, Guentzel M, Schaffer B, Herzig M, Wu X, Montgomery R, Parida B, Fedyk C, Yu J, Jorgensen J, Chambers J, Cap A, Arulanandam B Severe Acinetobacter baumannii sepsis is associated with elevation of pentraxin 3. Infect Immun, 2014;82(9):3910-8. 2014 [PMID: 25001601] (Mouse)
• Witasp A, Carrero J, Michaelsson K, Ahlstrom H, Kullberg J, Adamsson V, Riserus U, Larsson A, Helmersson-Karlqvist J, Lind L, Stenvinkel P, Arnlov J Inflammatory biomarker pentraxin 3 (PTX3) in relation to obesity, body fat depots and weight loss. Obesity (Silver Spring), 2014;22(5):1373-9. 2014 [PMID: 24415446] (Human)
• D'Angelo C, D'Angelo C, De Luca A, Zelante T, Bonifazi P, Moretti S, Giovannini G, Iannitti RG, Zagarella S, Bozza S, Campo S, Salvatori G, Romani L Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease. J. Immunol., 2009;183(7):4609-18. 2009 [PMID: 19734205] (Human)

Bioinformatics

• Gene Symbol: PTX3