alpha 1-Microglobulin Antibody (784917)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF
Clone
784917
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price

alpha 1-Microglobulin Antibody (784917) Summary

Immunogen
E. coli-derived recombinant human alpha 1‑Microglobulin
Gly20-Val203
Accession # P02760
Specificity
Detects human alpha 1‑Microglobulin in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant rat alpha 1-Microglobulin is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
AMBP
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/mL
  • Immunocytochemistry 8-25 ug/mL
Publications
Read Publication using
MAB7724 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for alpha 1-Microglobulin Antibody (784917)

  • A1M
  • alpha 1Microglobulin
  • alpha 1-Microglobulin
  • alpha-1-microglobulin/bikunin precursor
  • AMBP
  • bikunin
  • EDC1
  • HCP
  • HCPcomplex-forming glycoprotein heterogeneous in charge
  • HI30
  • IATIL
  • inter-alpha-trypsin inhibitor light chain
  • ITI
  • ITIL
  • ITILC
  • ITILgrowth-inhibiting protein 19
  • protein AMBP
  • protein HC
  • trypstatin
  • uristatin
  • uronic-acid-rich protein
  • UTI

Background

Human alpha 1-Microglobulin (alpha1-m/A1M; also protein HC) is a secreted, 31-32 kDa glycoprotein member of the lipocalin family, calycin superfamily of molecules. It is expressed by hepatocytes, keratinocytes, and endodermal derivatives in the embryo.  alpha 1-Microglobulin appears to act as a heme scavenger, protecting cells and collagen against oxidative damage. It also acts as an immunosuppressant, inhibiting polyclonal lymphocyte activation and dampening granulocyte migration in response to chemokines. alpha 1-Microglobulin circulates either as a monomer, or bound to IgA, albumin or prothrombin. Human alpha 1-Microglobulin is generated through cleavage of a precursor molecule termed AMBP. This AMBP should not be confused with AMBP-1, a 120-140 kDa adrenomedullin-binding protein that is also known as Complement Factor H. The AMBP precursor contains a 19 aa signal sequence, an N-terminal 183 aa alpha 1-Microglobulin protein (aa 20-203), and a C-terminal serine protease inhibitor termed bikunin (aa 206-352). alpha 1-Microglobulin possesses one lipocalin domain (aa 42-186). Although cleavage of AMBP in the Golgi apparatus typically generates a 31 kDa alpha 1-Microglobulin and 28 kDa bikunin molecule, the 60-65 kDa AMBP precursor can also be released intact.  alpha 1-Microglobulin will undergo extracellular processing, generating a 30 kDa isoform that is missing aa 199-203. There is one splice variant that shows a deletion of aa 48-57.  Over aa 20-203, human alpha 1-Microglobulin shares 76% aa sequence identity with both mouse and rat alpha 1-Microglobulin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for alpha 1-Microglobulin Antibody (MAB7724)(1)

We have publications tested in 1 confirmed species: Ovine.

We have publications tested in 1 application: Western Blot.


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Western Blot
(1)
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(1)
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Bioinformatics

Gene Symbol AMBP
Uniprot