TRPM2 Antibody - BSA Free


Western Blot: TRPM2 Antibody [NB110-81601] - Lane 1: CHO cells untransfected. Lane 2: CHO cell transfected with rat TRPM2 Lane 3: Mouse cortical neurons (cultured) Photo courtesy of Dr. Paco Herson, Oregon Health & more
Immunocytochemistry/ Immunofluorescence: TRPM2 Antibody [NB110-81601] - Neuro2a cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X PBS + 0.05% Triton X-100. The cells were more
Immunocytochemistry/ Immunofluorescence: TRPM2 Antibody [NB110-81601] - Staining of rat hippocampus using NB110-81601. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. Photo courtesy of Dr. more
Immunocytochemistry/ Immunofluorescence: TRPM2 Antibody [NB110-81601] - TRPM2 antibody was tested in Neuro2A cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and DyLight 550 more

Product Details

Reactivity Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr, IHC-P
BSA Free
1.0 mg/ml

Order Details

TRPM2 Antibody - BSA Free Summary

Synthetic peptide made to a C-terminal portion of the rat TRPM2 protein (within residues 1430-1508). [Swiss-Prot# Q5G856]
Cell membrane.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Immunocytochemistry/Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 1:200
  • Western Blot 1:500 - 1:1000
Application Notes
In Western blot a band is seen at ~181 kDa. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
181 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
TRPM2 Peptide (NB110-81601PEP)
Read Publications using
NB110-81601 in the following applications:

  • 3 publications
  • IHC
    3 publications
  • WB
    4 publications

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1.0 mg/ml
Immunogen affinity purified

Alternate Names for TRPM2 Antibody - BSA Free

  • EC
  • EREG1MGC133383
  • Estrogen-responsive element-associated gene 1 protein
  • KNP3LTrpC-2
  • Long transient receptor potential channel 2
  • LTrpC2
  • LTRPC2TRPC7transient receptor potential cation channel subfamily M member 2
  • NUDT9H
  • NUDT9L1
  • transient receptor potential cation channel, subfamily M, member 2
  • Transient receptor potential channel 7
  • TrpC7


TRP7 (transient receptor protein 7 or TRPC7) is the seventh identified member of mammalian TRPC channel family which includes nonselective cation channels that mediate changes in plasma membrane cation permeability induced by stimulation of PLC (phospholipase C, the cellular integrator that receives input from GPCRs/ RTK). Major cellular function of TRPC channels is to regulate Ca2+ influx across plasma membrane induced by stimulation of these receptors by hormones, neurotransmitters, and growth factors. Localized in the cell membrane and nuclear envelope as multi-pass membrane protein, TRPC7 interacts with with MX1, RNF24, PRKG1 etc. and PRKG1 mediated TRPC7 phosphorylation at Thr-15 site negatively regulates TRPC7's activity. TRP7 has been suggested to form a receptor-activated non-selective calcium permeant cation channel and is operated by a phosphatidylinositol second messenger system activated by RTKs or GPCRs. TRP7 is activated by DAG (diacylglycerol) and also upon intracellular calcium store depletion.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRPM2 Antibody (NB110-81601)(10)

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IHC, WB.

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Showing Publications 1 - 10 of 10.
Publications using NB110-81601 Applications Species
Zong P, Feng J, Yue Z et al. Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury Neuron [PMID: 35421327]
Wang W, Yang Q, Zhou C et al. Transcriptomic changes in the hypothalamus of ovariectomized mice: Data from RNA-seq analysis Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft Jan 12 2022 [PMID: 35032566] (IHC, Mouse) IHC Mouse
Yee AG, Freestone PS, Bai JZ, Lipski J Paradoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone. Exp. Neurol. Oct 19 2016 [PMID: 27771354] (IHC) IHC
Rah SY, Kwak JY, Chung YJ, Kim UH ADP-ribose/TRPM2-mediated Ca2+) signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. Sci Rep 2015 Mar 25 [PMID: 25879940] (ICC/IF, Mouse)

This publication used the DL550 conjugated form of this antibody (NB110-81601R)
ICC/IF Mouse
Chung MK, Asgar J, Lee J et al. The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia Neuroscience 2015 Apr 04 [PMID: 25849615] (WB, Rat) WB Rat
Lu S, Xiang L, Clemmer JS et al. Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 (TRPM2) channels. Microcirculation 2014 Jul 24 [PMID: 25059284] (WB, Rat)

TRPM2 antibody used for WB on tissue lysate of pulmonary arteries from control male lean Zucker/LZ Rats and hyperglycemic LZ rats (streptozotocin/STZ 50mg/kg -induced type I diabetic model). Figure 1 shows the down-regulation of TRPM2-L channel in STZ-treated type I diabetic LZ.
WB Rat
Roberge S, Roussel J, Andersson DC et al. TNF-alpha-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes. Cardiovasc. Res. 2014 May 06 [PMID: 24802330] (WB, Mouse) WB Mouse
Melzer N, Hicking G, Gobel K, Wiendl H. TRPM2 Cation Channels Modulate T Cell Effector Functions and Contribute to Autoimmune CNS Inflammation PLoS One 2012 [PMID: 23077651] (ICC/IF, Mouse) ICC/IF Mouse
Chung KK, Freestone PS, Lipski J. Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. J Neurophysiol;106(6):2865-75. 2011 Dec. [PMID: 21900507] (IHC, Rat) IHC Rat
Bai JZ, Lipski J. Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. Neurotoxicology. 2010 Jan 12. [PMID: 20064552] (WB, ICC/IF, Rat) WB, ICC/IF Rat

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies


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Array NB110-81601

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Blogs on TRPM2.

Winter is coming, and TRPM8 welcomes the cold!
TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...  Read full blog post.

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Gene Symbol TRPM2