TRPM2 Antibody


Western Blot: TRPM2 Antibody [NB110-81601] - Lane 1: CHO cells untransfected. Lane 2: CHO cell transfected with rat TRPM2 Lane 3: Mouse cortical neurons (cultured) Photo courtesy of Dr. Paco Herson, Oregon Health & more
Immunocytochemistry/ Immunofluorescence: TRPM2 Antibody [NB110-81601] - TRPM2 antibody was tested in Neuro2A cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 more
Immunocytochemistry/ Immunofluorescence: TRPM2 Antibody [NB110-81601] - Staining of rat hippocampus using NB110-81601. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. Photo courtesy of Dr. more

Product Details

Reactivity Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr
0.90 mg/ml

TRPM2 Antibody Summary

Synthetic peptide made to a C-terminal portion of the rat TRPM2 protein (within residues 1430-1508). [Swiss-Prot# Q5G856]
Cell membrane.
This is specific for isoform 1, or the long isoform (TRPM2-L), of TRPM2.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS, 30% glycerol
0.1% Sodium Azide
0.90 mg/ml
Immunogen affinity purified


Application Notes
This TRPM2 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry and Western blot, where a band is seen at ~181 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
181 kDa
Control Peptide
TRPM2 Peptide (NB110-81601PEP)
Read Publications using
NB110-81601 in the following applications:

  • 3 publications
  • IHC
    1 publication
  • WB
    4 publications

Reactivity Notes

Mouse and rat.

Alternate Names for TRPM2 Antibody

  • EC
  • EREG1MGC133383
  • Estrogen-responsive element-associated gene 1 protein
  • KNP3LTrpC-2
  • Long transient receptor potential channel 2
  • LTrpC2
  • LTRPC2TRPC7transient receptor potential cation channel subfamily M member 2
  • NUDT9H
  • NUDT9L1
  • transient receptor potential cation channel, subfamily M, member 2
  • Transient receptor potential channel 7
  • TrpC7


TRP7 (transient receptor protein 7 or TRPC7) is the seventh identified member of mammalian TRPC channel family which includes nonselective cation channels that mediate changes in plasma membrane cation permeability induced by stimulation of PLC (phospholipase C, the cellular integrator that receives input from GPCRs/ RTK). Major cellular function of TRPC channels is to regulate Ca2+ influx across plasma membrane induced by stimulation of these receptors by hormones, neurotransmitters, and growth factors. Localized in the cell membrane and nuclear envelope as multi-pass membrane protein, TRPC7 interacts with with MX1, RNF24, PRKG1 etc. and PRKG1 mediated TRPC7 phosphorylation at Thr-15 site negatively regulates TRPC7's activity. TRP7 has been suggested to form a receptor-activated non-selective calcium permeant cation channel and is operated by a phosphatidylinositol second messenger system activated by RTKs or GPCRs. TRP7 is activated by DAG (diacylglycerol) and also upon intracellular calcium store depletion.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRPM2 Antibody (NB110-81601)(7)

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IHC, WB.

Filter By Application
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Showing Publications 1 - 7 of 7.
Publications using NB110-81601 Applications Species
Rah SY, Kwak JY, Chung YJ, Kim UH. ADP-ribose/TRPM2-mediated Ca2+) signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. Sci Rep 2015 Apr 17 [PMID:25879940] (ICC/IF, Mouse) ICC/IF Mouse
Chung MK, Asgar J, Lee J et al. The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia Neuroscience 2015 Apr 04 [PMID:25849615] (WB, Rat) WB Rat
Lu S, Xiang L, Clemmer JS et al. Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 (TRPM2) channels. Microcirculation 2014 Jul 24 [PMID:25059284] (WB, Rat) WB Rat
Roberge S, Roussel J, Andersson DC et al. TNF-alpha-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes. Cardiovasc. Res. 2014 May 06 [PMID:24802330] (WB, Mouse) WB Mouse
Melzer N, Hicking G, Gobel K, Wiendl H. TRPM2 Cation Channels Modulate T Cell Effector Functions and Contribute to Autoimmune CNS Inflammation PLoS One 2012 [PMID:23077651] (ICC/IF, Mouse) ICC/IF Mouse
Chung KK, Freestone PS, Lipski J. Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. J Neurophysiol;106(6):2865-75. 2011 Dec. [PMID:21900507] (IHC, Rat) IHC Rat
Bai JZ, Lipski J. Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. Neurotoxicology. 2010 Jan 12. [PMID:20064552] (WB, ICC/IF, Rat) WB, ICC/IF Rat

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Product General Protocols

View specific protocols for TRPM2 Antibody (NB110-81601): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for TRPM2 Antibody (NB110-81601) (0)

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB110-81601AF405
Alexa Fluor (R) 488 Labeled NB110-81601AF488
Alexa Fluor (R) 647 Labeled NB110-81601AF647
Alexa Fluor (R) 700 Labeled NB110-81601AF700
Biotin Labeled NB110-81601B
DyLight 405 Labeled NB110-81601V
DyLight 488 Labeled NB110-81601G
DyLight 550 Labeled NB110-81601R
DyLight 650 Labeled NB110-81601C
FITC Labeled NB110-81601F
HRP Labeled NB110-81601H

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Contact Information

Product PDFs


Gene Symbol TRPM2

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