TRPM8 Antibody

Images

 
Western Blot: TRPM8 Antibody [NBP1-97311] - WB analysis of TRPM8 in PC12 cell lysate.
Immunocytochemistry/ Immunofluorescence: TRPM8 Antibody [NBP1-97311] - TRPM8 antibody was tested in U2OS cells with FITC (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).
Immunohistochemistry: TRPM8 Antibody [NBP1-97311] - IHC analysis of TRPM8 in mouse prostate using DAB with hematoxylin counterstain.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.30 mg/ml

TRPM8 Antibody Summary

Immunogen
A synthetic peptide made to an internal portion of the human TRPM8 protein (between residues 250-300) [UniProt Q7Z2W7]
Localization
Membrane; Multi-pass membrane protein. Ability to translocate to nucleus
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TRPM8
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunocytochemistry/Immunofluorescence 1:100
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin 1:300
Application Notes
This TRPM8 antibody is useful for Western Blot where a band is seen ~127 kDa, Immunocytochemistry/Immunofluorescence, and IHC-paraffin embedded sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Control Peptide
TRPM8 Peptide (NBP1-97311PEP)
Publications
Read Publication using
NBP1-97311 in the following applications:

  • IHC
    1 publication

Reactivity Notes

Human, rat, and mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
0.05% Sodium Azide
Concentration
1.30 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TRPM8 Antibody

  • CMR1
  • Long transient receptor potential channel 6
  • LTRPC6
  • LTrpC-6
  • MGC2849
  • short form of the TRPM8 cationic channel
  • transient receptor potential cation channel, subfamily M, member 8
  • Transient receptor potential p8
  • transient receptor potential subfamily M member 8
  • TRPM8
  • TRPP8
  • trp-p8
  • TRPP8transient receptor potential cation channel subfamily M member 8

Background

TRPM8 (TRPP8, LTRPC6) is a transient receptor cation channel that has been shown to be a major cold receptor in sensory neurons. TRPM8 has been theorized to be activated by cold temperatures, voltage, calcium store depletion, some lipids, and also the compounds that produce cooling sensations such as menthol or icilin. TRPM8 is aberrantly over-expressed in pancreatic cancer along with colon, lung, breast and skin cancers, and is proposed to be required for cellular proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRPM8 Antibody (NBP1-97311)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: IHC.


Filter By Application
IHC
(1)
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Filter By Species
Rat
(1)
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Product General Protocols

View specific protocols for TRPM8 Antibody (NBP1-97311): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for TRPM8 Antibody (NBP1-97311) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP1-97311AF405
Alexa Fluor 488 Labeled NBP1-97311AF488
Alexa Fluor 647 Labeled NBP1-97311AF647
Alexa Fluor 700 Labeled NBP1-97311AF700
Biotin Labeled NBP1-97311B
DyLight 405 Labeled NBP1-97311V
DyLight 488 Labeled NBP1-97311G
DyLight 550 Labeled NBP1-97311R
DyLight 650 Labeled NBP1-97311C
FITC Labeled NBP1-97311F
HRP Labeled NBP1-97311H

Additional Array Products

Bioinformatics Tool for TRPM8 Antibody (NBP1-97311)

Discover related pathways, diseases and genes to TRPM8 Antibody (NBP1-97311). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for TRPM8 Antibody (NBP1-97311)

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Pathways for TRPM8 Antibody (NBP1-97311)

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PTMs for TRPM8 Antibody (NBP1-97311)

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Research Areas for TRPM8 Antibody (NBP1-97311)

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Blogs on TRPM8.

Winter is coming, and TRPM8 welcomes the cold!
TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...  Read full blog post.

TRPM8: The Multi-functional Ion Channel
TRPM8 is a transmembrane homo-tetramer ion channel that is activated by cold temperatures, cooling agents, and menthol stimuli. It belongs to a subgroup within the larger family of TRP cation channels (including the TRPV1 capsaicin receptor) that are...  Read full blog post.

Touch Infographic: From Touch Receptors to the Brain
The body contains thousands of receptors and nerves which allow us to experience the sense of touch, also referred to as tactile perception. The somatosensory system allows organisms to perceive and decode a wide range of tactile stimuli to allow for...  Read full blog post.

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Bioinformatics

Gene Symbol TRPM8
Entrez
Uniprot