TRPV4 Antibody


Western Blot: TRPV4 Antibody [NB110-74960] - WB on mouse brain lysate (reduced, denatured) using Rabbit antibody to TRPV4 at 1 : 1000 dilution.
Immunohistochemistry-Paraffin: TRPV4 Antibody [NB110-74960] - Rat kidney using Rabbit antibody to TRPV4, dilution 1: 1000, incubated 30 min at RT (using Autostainer).
Immunohistochemistry-Paraffin: TRPV4 Antibody [NB110-74960] - Rat kidney using Rabbit antibody to TRPV4, dilution 1: 1000, incubated 30 min at RT (using Autostainer)

Product Details

Reactivity Hu, Mu, Rt, PmSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P

Order Details

TRPV4 Antibody Summary

A synthetic peptide from aa region 300-400 of mouse TRPV4 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human.
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  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:1000-1:2000
  • Immunohistochemistry-Paraffin 1: 1000 - 1: 2000
  • Western Blot 1:1000-1:2000
Application Notes
ICC/IF, IHC reactivity reported in (PMID: 22761937).
Theoretical MW
98 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publications using
NB110-74960 in the following applications:

  • 1 publication
  • IHC
    1 publication
  • WB
    1 publication

Reactivity Notes

Marmoset (100%).

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Whole antisera
No Preservative
Reconstitution Instructions
Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability.

Alternate Names for TRPV4 Antibody

  • CMT2Cosmosensitive transient receptor potential channel 4
  • HMSN2C
  • Osm-9-like TRP channel 4
  • transient receptor potential cation channel subfamily V member 4
  • transient receptor potential cation channel, subfamily V, member 4
  • Transient receptor potential protein 12
  • TRP12OSM9-like transient receptor potential channel 4
  • TrpV4
  • Vanilloid receptor-like channel 2
  • Vanilloid receptor-like protein 2
  • vanilloid receptor-related osmotically activated channel
  • Vanilloid receptor-related osmotically-activated channel
  • VRL2
  • VRL-2
  • VR-OAC


TRPV4 is a cation-selective channel, activated in response to systemic osmotic pressure. FUNCTION: Non-selective calcium permanent cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. SUBUNIT: Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 3 ANK repeats.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRPV4 Antibody (NB110-74960)(4)

Reviews for TRPV4 Antibody (NB110-74960) (0)

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for TRPV4 Antibody (NB110-74960). (Showing 1 - 1 of 1 FAQs).

  1. We have a customer who is looking for an antibody that is suitable to detect TRPV4/Vanilloid receptor-like protein 2 in sheep FFPE tissues. Could you allign the immunizing peptid of NB110-74960 and NB100-98910 against the sheep sequence (if you have it - I could not find the sheep TRPV4 sequence in UniProt and also, the customer did not supply the sequence) and inform us on the homology between the peptids used to generate NB110-74960/NB100-98910 and the sheep sequence?
    • Sheep and Human TRPV4 are over 90% similar, so most antibodies to the human sequence will be predicted to cross-react. NB110-74960 is probably the best choice for this.

Secondary Antibodies


Isotype Controls

Additional TRPV4 Products

Array NB110-74960

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Blogs on TRPV4.

Winter is coming, and TRPM8 welcomes the cold!
TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...  Read full blog post.

OS9: Taking proteins to the ER finish line
The OS9 protein is a lectin/glycoprotein that maintains endoplasmic reticulum (ER) quality control and ER-associated degradation (the so-called ERAD pathway) of newly synthesized proteins. It is essential for the recognition of terminally misfolded no...  Read full blog post.

Touch Infographic: From Touch Receptors to the Brain
The body contains thousands of receptors and nerves which allow us to experience the sense of touch, also referred to as tactile perception. The somatosensory system allows organisms to perceive and decode a wide range of tactile stimuli to allow for ...  Read full blog post.

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Gene Symbol TRPV4