TrkB [p Tyr816] Antibody

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

TrkB [p Tyr816] Antibody Summary

Immunogen
A synthetic peptide from the region around (and including) phospho Y816 site of rat TrkB (BDNF/NT-3 growth factors receptor, TrkB tyrosine kinase, Trk-B) conjugated to an immunogenic carrier protein was used as the immunogen.
Modification
p Tyr816
Localization
subcellular location: membrane; single-pass type i membrane protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NTRK2
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 10-50 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 10-50 ug/ml
  • Immunohistochemistry-Frozen 10-50 ug/ml
  • Immunohistochemistry-Paraffin 10-50 ug/ml
Application Notes
This antibody has been used in IHC-Frozen as reported in the literature (PMID: 23432085) and ICC/IF (PMID: 23658180).
Control
TrkB Overexpression Lysate
Control Peptide
TrkB Peptide (NBP1-03499PEP)
Publications
Read Publications using
NBP1-03499 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Purity
IgG purified
Reconstitution Instructions
Please note the larger size(s) come in lyophilized form and the sample size will be in liquid formate. Reconstitute with 0.5 ml sterilized water. Add glycerol (1:1) for additional stability.

Alternate Names for TrkB [p Tyr816] Antibody

  • BDNF/NT-3 growth factors receptor
  • EC 2.7.10
  • EC 2.7.10.1
  • GP145-TrkB
  • Neurotrophic tyrosine kinase receptor type 2
  • neurotrophic tyrosine kinase, receptor, type 2
  • NTRK2
  • TrkB tyrosine kinase
  • TrkB
  • trk-B
  • TRKBBDNF-tropomyosine receptor kinase B
  • tyrosine kinase receptor B

Background

Receptor for brain-derived neurotrophic factor (bdnf), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (ngf). involved in the development and/or maintenance of the nervous system. this is a tyrosine-protein kinase receptor. known substrates for the trk receptors are shc1, pi-3 kinase, and plc-gamma-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TrkB Antibody (NBP1-03499)(7)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: ICC/IF, IHC, IHC-Fr, WB.


Filter By Application
ICC/IF
(2)
IHC
(2)
IHC-Fr
(1)
WB
(2)
All Applications
Filter By Species
Human
(1)
Mouse
(2)
Rat
(3)
All Species
Showing Publications 1 - 7 of 7.
Publications using NBP1-03499 Applications Species
Ma Y, Deng M, Zhao XQ, Liu M Alternatively Polarized Macrophages Regulate the Growth and Differentiation of Ependymal Stem Cells through the SIRT2 Pathway Exp Neurobiol Apr 30 2020 [PMID: 32408405] (WB, Mouse) WB Mouse
Ding H, Chen J, Su M et al. BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis J Neuroinflammation Jan 13 2020 [PMID: 31931832] (ICC/IF, Rat) ICC/IF Rat
Li W, Yu J, Liu Y et al. Elevation of Brain Magnesium Prevents and Reverses Cognitive Deficits and Synaptic Loss in Alzheimer's Disease Mouse Model. J Neurosci 2013 May 8 [PMID: 23658180] (ICC/IF, IHC, Mouse) ICC/IF, IHC Mouse
Gotoh K, Masaki T, Chiba S et al. Brain-derived neurotrophic factor, corticotropin-releasing factor, and hypothalamic neuronal histamine interact to regulate feeding behavior J Neurochem 2013 Feb 23 [PMID: 23432085] (IHC-Fr, Rat) IHC-Fr Rat
Zhu M, Lu C, Li W. Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone J Neurochem 2012 Nov 28 [PMID: 23189969] (WB, Human) WB Human
Gotoh K, Masaki T, Chiba S et al. Hypothalamic BDNF regulates glucagon secretion mediated by pancreatic efferent nerve J Neuroendocrinol 2012 Nov 15 [PMID: 23157205] (IHC, Rat) IHC Rat
Tsai CY, Chan JY, Hsu KS, et al. Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus PLoS One 2012 [PMID: 22442695]

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for TrkB Antibody (NBP1-03499) (0)

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

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Blogs on TrkB.

TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its...  Read full blog post.

TrkB and Nervous System Function
Neutrophins and their receptors play an important role in regulating the development of both the central and peripheral nervous systems. Neurotrophin ligand binding to each of their respective Trk cellular receptors is essential for the growth and sur...  Read full blog post.

TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...  Read full blog post.

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Bioinformatics

Gene Symbol NTRK2
Entrez
Uniprot