TLR6 Antibody

Product Discontinued

TLR6 Antibody Summary

• Immunogen: Synthetic peptide made to a C-terminal portion of the human TLR6 protein (within residues 700-796). [Swiss-Prot# Q9Y2C9]
• Localization: Cell membrane; Single-pass type I membrane protein
• Predicted Species: Sheep (92%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TLR6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000-1:2000
• Application Notes: This TLR6 antibody is useful for Western blot, where a band is seen at ~96 kDa. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Theoretical MW: 96 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Agonist:
  • MALP-2, TLR6 and TLR2 ligand NBP2-26219
• Control:

  TLR6 Overexpression Lysate

Reactivity Notes

Immunogen sequence has 92% homology to sheep.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-Citrate/Phosphate (pH 7.0 - 8.0)
• Preservative: 0.1% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for TLR6 Antibody

• CD286 antigen
• CD286
• TLR6
• toll-like receptor 6

Background

TLR6 (toll-like receptor 6, also called CD286) belongs the family of TLRs which are membrane receptors with potential of acting as gatekeepers of the innate immunity through recognizing microbial components and initiating activation of an adequate immune response. Localized in cell membrane as well as in cytoplasmic vesicle/phagosome membrane as single-pass type I membrane protein, TLR6 is expressed in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells. TLR6 participates in the innate immune response to Gram-+ve bacteria and fungi. It specifically recognize diacylated/triacylated lipopeptides, and has the ability to recognize mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor, phenol-soluble modulin and Borrelia burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It acts via MYD88 and TRAF6, leading to NFkB activation, cytokine secretion and inflammatory response. Moreover, it has been shown to bind MYD88 and dimerize with TLR2, wherein TLR6- TLR2 heterodimers recognize a large number of lipidcontaining molecules and transducers inflammatory signalling in a variety of cell type.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TLR6
• Entrez:
  • 10333(Human)
  • 21899(Mouse)
  • 305353(Rat)
• Uniprot:
  • Q9Y2C9(Human)