Exploring Various Studies on TLR6 Expression

Thu, 03/06/2014 - 15:10

The protein TLR6 is one member of the large Toll-like receptor (TLR) family, which governs the activation of the innate immunity system and pathogen recognition in cells. The TLR family is highly conserved from Drosophila to humans, and all the family members have a high degree of both functional and structural homology. TLRs modulate cytokine production by cells that is required to effectively establish innate immunity.  Interesting mesenchymal stem cell (MSC) differentiation studies in van den Berk’s lab with the TLR6 antibody, demonstrated that the expression patterns of TLRs and ligand-induced signaling and outcome vary between MSCs derived from primitive, unrestricted lineage cord blood compared to those from bone marrow1.  Harman et al used the TLR6 antibody to perform analogous lineage gene expression profiles in sorted human blood and skin dendritic cells (DCs) and found differential expression of the novel genes - such as C-type lectin receptors and galectins - in particular population subsets that was dictated more by anatomical origin than parental lineage2.

Flow Cytometry: TLR6 Antibody Flow Cytometry: TLR6 Antibody

Detailed characterization on TLR-mediated expression and function was performed in human T-lymphocytes with immunoblotting, flow cytometry, and microarray analysis using a panel of antibodies including the TLR6 antibody3. These comprehensive studies used the TLR6 antibody to establish the role of interferon gamma (IFN-gamma) in immune response to TLR ligands triggered by microbe- or tumor-derived phosphoantigens. Further inflammation and infectious studies were done with the TLR6 antibody by Murciano‘s group4. In their aging studies, they exposed a variety of blood cells to the opportunistic fungi Candida albicans to compare in vitro responses between young versus aged donors – their data found no defects in TLR expression or signaling.

  1. 20196781
  2.  23183897
  3. 19703014
  4. 17714490

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