TLR10 Antibody

Product Discontinued

TLR10 Antibody Summary

• Immunogen: Synthetic peptide made to an N-terminal portion of human TLR10 (within residues 1-100). [Swiss-Prot# Q9BXR5]
• Localization: Membrane; Single-pass type I membrane protein.
• Predicted Species: Bovine (90%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TLR10
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:500-1:1000
  • Western Blot 2 ug/ml
• Application Notes: This TLR10 antibody is useful for Western blot, where a band is seen at ~94 kDa. Immunohistochemistry was reported in scientific literature. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. Use in Immunohistochemistry reported in scientific literature (PMID: 23279063).
• Theoretical MW: 94 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control:

  TLR10 Overexpression Lysate

Reactivity Notes

Human. Immunogen sequence has 90% homology to bovine.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-Citrate/Phosphate (pH 7.0 - 8.0)
• Preservative: 0.1% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for TLR10 Antibody

• CD290 antigen
• CD290
• MGC104967
• MGC126398
• MGC126399
• TLR10
• toll-like receptor 10

Background

Toll-like receptors (TLRs) are membrane proteins on many cells involved with innate immunity such as macrophages, dendritic cells, neutrophils, mucosal epithelial cells, and endothelial cells. Ten mammalian TLRs have been identified and all have distinct specificities for microbial ligands. Upon recognition of a microbial product, TLRs initiate a signaling pathway to activate innate immunity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TLR10 Antibody (NB110-83980)(1)

Publication using NB110-83980

• Mulla MJ, Myrtolli K, Tadesse S et al. Cutting-Edge Report: TLR10 Plays a Role in Mediating Bacterial Peptidoglycan-Induced Trophoblast Apoptosis Am J Reprod Immunol 2012-12-28 [PMID: 23279063] (WB, IF/IHC, Human)

Bioinformatics

• Gene Symbol: TLR10
• Entrez:
  • 81793(Human)
• Uniprot:
  • Q9BXR5()