TLR10 Antibody (158C1114)

Product Discontinued

TLR10 Antibody (158C1114) Summary

• Immunogen: This antibody was developed against a synthetic peptide of the extracellular domain of human TLR10.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TLR10
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 2 ug/10^6 cells
  • Western Blot 5-10 ug/ml

Reactivity Notes

This antibody is reactive to Human

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.2 ml PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein G purified

Alternate Names for TLR10 Antibody (158C1114)

• CD290 antigen
• CD290
• MGC104967
• MGC126398
• MGC126399
• TLR10
• toll-like receptor 10

Background

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR10 is highly homologous to TLRs 1 and 6 and is most highly expressed in lymphoid tissues. Most recently genetic variation in TLR10 has been associated with contributing to asthma risk. It should be noted that TLR10 exists in mice only as a pseudogene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TLR10 Antibody (NBP2-24958)(4)

Publications using NBP2-24958

• Kim D, Kim YJ, Koh HS et al. Reactive Oxygen Species Enhance TLR10 Expression in the Human Monocytic Cell Line THP-1. Int J Mol Sci. 2010-09-29 [PMID: 21152300] (IHC-P, Human)
  
  Details:
  TLR10 (IMG-386D). Flow (cell surface): Human Monocyte THP-1 Cells, data described but not shown.
• Bell MP, Svingen PA, Rahman MK et al. FOXP3 regulates TLR10 expression in human T regulatory cells. J Immunol. 2007-08-01 [PMID: 17641056] (Flow-CS, WB, Human)
  
  Details:
  Products cited: (1) TLR10 mAb (IMG-386A): Flow (Cell Surface), Fig 1B [freshly isolated, resting human Treg (CD4+/CD25++) and Non-Treg (CD4+/CD25-)] cells from healthy donors; (2) TLR10 pAb (IMG-5630): WB, Fig 1C [freshly isolated, resting human Treg (CD4
• Zola H, Swart B, Banham A et al. CD molecules 2006--human cell differentiation molecules J Immunol Methods 2007-01-30 [PMID: 17174972]
  
  Details:
  This citation used the PerCP version of this antibody.
• Hasan U et al. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J Immunol 2005-03-01 [PMID: 15728506]

Bioinformatics

• Gene Symbol: TLR10
• Uniprot:
  • Q9BXR5()