Tie-2 Antibody [HRP]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
HRP

Tie-2 Antibody [HRP] Summary

Immunogen
A genomic peptide made to an internal region of the human TIE2 protein (within residues 250-400). [Swiss-Prot Q02763]
Localization
Membrane, single pass type-1 membrane protein
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TEK
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This TIE2 antibody is useful for Western blot where a band is seen ~150 kDa, and Immunohistochemistry-paraffin embedded sections where membrane, cytoplasmic and nuclear signal is seen in mouse intestines. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Readout System

Reactivity Notes

Human and mouse

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
No Preservative
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Tie-2 Antibody [HRP]

  • angiopoietin-1 receptor
  • CD202b antigen
  • CD202b
  • EC 2.7.10
  • EC 2.7.10.1
  • hTIE2
  • p140 TEK
  • soluble TIE2 variant 1
  • soluble TIE2 variant 2
  • TEK tyrosine kinase, endothelial
  • TEK
  • Tie2
  • Tie-2
  • TIE2CD202b
  • Tunica interna endothelial cell kinase
  • Tyrosine-protein kinase receptor TEK
  • Tyrosine-protein kinase receptor TIE-2
  • venous malformations, multiple cutaneous and mucosal
  • VMCM
  • VMCM1

Background

The endothelium-specific receptor tyrosine kinase 2 binds and interacts with angiogenic proteins. In acute inflammation, TIE2 signals vascular endothelial cells to stop early leakiness in vessels. This interaction depends partly upon VEGF, PLGF and PDGF. In pregnancy, vascular remodeling is initiated and mediated by VEGF and PLGF; however, recent studies demonstrate that failure of effective vascular remodeling in pre-eclampsia is associated with the erroneously low production of soluble TIE2. Following cerebral stroke, TIE2 production is also critical for appropriate vascular endothelial cell migration and differentiation in response and repair mechanisms. In most cases, damage caused by diabetes, stroke, hypoxia and other cellular insults to vascular endothelial cells is repaired through effective balance of TIE2 with other angiogenic proteins. When the ratio of these proteins is inappropriate, and TIE2 expression decreases, vascular damage occurs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TEK
Entrez