Tie-2 Antibody [FITC]


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Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P
Please see the vial label for concentration. If unlisted please contact technical services.

Tie-2 Antibody [FITC] Summary

A genomic peptide made to an internal region of the human TIE2 protein (within residues 250-400). [Swiss-Prot Q02763]
Membrane, single pass type-1 membrane protein
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C in the dark.
FITC (A=495, E=519)
0.05% Sodium Azide
Immunogen affinity purified


  • Western Blot 1:2500
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin 1:200
Application Notes
This TIE2 antibody is useful for Western blot where a band is seen ~150 kDa, and Immunohistochemistry-paraffin embedded sections where membrane, cytoplasmic and nuclear signal is seen in mouse intestines. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Reactivity Notes

Human and mouse

Alternate Names for Tie-2 Antibody [FITC]

  • angiopoietin-1 receptor
  • CD202b antigen
  • CD202b
  • EC 2.7.10
  • EC
  • hTIE2
  • p140 TEK
  • soluble TIE2 variant 1
  • soluble TIE2 variant 2
  • TEK tyrosine kinase, endothelial
  • TEK
  • Tie2
  • TIE-2
  • TIE2CD202b
  • Tunica interna endothelial cell kinase
  • Tyrosine-protein kinase receptor TEK
  • Tyrosine-protein kinase receptor TIE-2
  • venous malformations, multiple cutaneous and mucosal
  • VMCM
  • VMCM1


TIE2 (tyrosine-protein kinase receptor TIE-2) is an endothelial-selective RTK that is essential to angiopoietin (ANGPT)/TIE2 system which constitutes transmembrane endothelial tyrosine kinase TIE2 and its circulating ligands (ANGPT-1, -2 and ANGPT-3, -4). Activation/phosphorylation state of TIE2 regulates the baseline endothelial quiescence and its response to pathogens as well as cytokines, and TIE2 phosphorylation is largely controlled by the ratio of agonistic ligand ANGPT-1 and competitive inhibitor ANGPT-2. TIE2 exists as homodimer or heterodimer (with TIE1) and interacts with ANGPT1, ANGPT2, ANGPT4, TEK, TNIP2, SHC1, PTPRB, DOK2, GRB2, GRB7, GRB14, PIK3R1 and PTPN11/SHP2 etc for exerting its diverse biological functions. TIE2 regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion, actin cytoskeleton reorganization, and maintenance of vascular quiescence. It exerts anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels, and activates or inhibits angiogenesis, depending on the context (inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts). Targeted deletion of TIE2 or its major agonist ligand, Angpt-1, results in embryonic lethality in mice characterized by defects in blood vessel maturation, lack of recruitment of supporting pericytes and impaired basement membrane formation.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies


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Contact Information

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Gene Symbol TEK

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