Tie-2 Products

Antibodies
Tie-2 Antibody [Unconjugated] ...
Tie-2 Antibody [Unconjugated]
AF313
Species: Hu
Applications: WB, Simple Western, IHC, Block
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Tie-2 [p Tyr992] Antibody [Un ...
Tie-2 [p Tyr992] Antibody [Unconju...
AF2720
Species: Hu, Mu
Applications: WB, ICFlow
Host: Rabbit Polyclonal
ELISA Kits
Tie-2 ELISA Kit [Biotin]
Tie-2 ELISA Kit [Biotin]
KA0193
Species: Hu
Tie-2 ELISA Kit
Tie-2 ELISA Kit
NBP1-83746
Lysates
Tie-2 Overexpression Lysate ( ...
Tie-2 Overexpression Lysate (Native)
NBL1-16808
Applications: WB
Proteins
Tie-2 Recombinant Protein
Tie-2 Recombinant Protein
NBP2-52191
Species: Mu
Applications: PAGE
RNAi
Tie-2 RNAi
Tie-2 RNAi
H00007010-R04
Species: Hu

Description

TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin like loops separated by three epidermal growth factor like repeats that are connected to three fibronectin type III like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell smooth muscle cell communication in venous morphogenesis.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Mouse
Product By Gene ID 7010
Alternate Names
  • EC 2.7.10.1
  • EC 2.7.10
  • p140 TEK
  • CD202b antigen
  • hTIE2
  • soluble TIE2 variant 2
  • Tyrosine-protein kinase receptor TIE-2
  • soluble TIE2 variant 1
  • Tyrosine-protein kinase receptor TEK
  • angiopoietin-1 receptor
  • Tunica interna endothelial cell kinase
  • CD202B
  • VMCM1
  • venous malformations, multiple cutaneous and mucosal
  • TIE-2
  • TIE2CD202b
  • VMCM
  • TEK tyrosine kinase, endothelial

Research Areas for Tie-2

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Phospho-Specific
Protein Kinase

Bioinformatics Tool for Tie-2

Discover related pathways, diseases and genes to Tie-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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