Tie-2 Products

Antibodies
Tie-2 Antibody [Unconjugated] ...
Tie-2 Antibody [Unconjugated]
AF313
Species: Hu
Applications: WB, Simple Western, IHC, B/N
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
Tie-2 [p Tyr992] Antibody [Un ...
Tie-2 [p Tyr992] Antibody [Unconju...
AF2720
Species: Hu, Mu
Applications: WB, CyTOF-ready, Flow
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
Tie-2 Antibody
Tie-2 Antibody
AF762
Species: Mu, Rt
Applications: WB, B/N
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
ELISA Kits
Human Tie-2 ELISA Kit (Colori ...
Human Tie-2 ELISA Kit (Colorimetric)
NBP1-83746
Species: Hu
Applications: ELISA
Lysates
Tie-2 Knockout HeLa Cell Lysa ...
Tie-2 Knockout HeLa Cell Lysate
NBP2-78437
Species: Hu
Tie-2 Overexpression Lysate
Tie-2 Overexpression Lysate
NBL1-16808
Species: Hu
Applications: WB
Proteins
Recombinant Human Tie-2 Fc Ch ...
Recombinant Human Tie-2 Fc Chimera...
313-TI
Species: Hu
Applications: Binding Activity
Formulation Catalog # Availability Price  
Recombinant Mouse Tie-2 Fc Ch ...
Recombinant Mouse Tie-2 Fc Chimera...
762-T2
Species: Mu
Applications: Binding Activity
Formulation Catalog # Availability Price  
Recombinant Zebrafish Tie-2 F ...
Recombinant Zebrafish Tie-2 Fc Chi...
928-T2
Species: Ze
Applications: Binding Activity
Formulation Catalog # Availability Price  

Description

TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin like loops separated by three epidermal growth factor like repeats that are connected to three fibronectin type III like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell smooth muscle cell communication in venous morphogenesis.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Mouse
Product By Gene ID 7010
Alternate Names
  • EC 2.7.10.1
  • EC 2.7.10
  • p140 TEK
  • CD202b antigen
  • hTIE2
  • soluble TIE2 variant 2
  • Tyrosine-protein kinase receptor TIE-2
  • soluble TIE2 variant 1
  • Tyrosine-protein kinase receptor TEK
  • angiopoietin-1 receptor
  • Tunica interna endothelial cell kinase
  • CD202B
  • VMCM1
  • venous malformations, multiple cutaneous and mucosal
  • TIE-2
  • TIE2CD202b
  • VMCM
  • TEK tyrosine kinase, endothelial

Research Areas for Tie-2

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Phospho-Specific
Protein Kinase

Bioinformatics Tool for Tie-2

Discover related pathways, diseases and genes to Tie-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Tie-2 Blog Posts

Check out the latest blog posts on Tie-2.
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