Thrombomodulin/BDCA-3 Antibody (SR1034) - BSA Free

Western Blot: Thrombomodulin/BDCA-3 Antibody (SR1034) [NBP3-22533] - Western blot analysis using NBP3-22533 in mouse lung cell lysate.

• Reactivity: Mu, Rt
• Applications: WB, Flow, IHC
• Clone: SR1034
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Thrombomodulin/BDCA-3 Antibody (SR1034) - BSA Free Summary

• Description: Novus Biologicals Rabbit Thrombomodulin/BDCA-3 Antibody (SR1034) - BSA Free (NBP3-22533) is a recombinant monoclonal antibody validated for use in IHC, WB and Flow. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthesized peptide derived from human Thrombomodulin/BDCA-3 (Uniprot #: P15306)
• Specificity: Detects endogenous levels of total Thrombomodulin/BDCA-3
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: THBD
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:50
  • Immunohistochemistry 1:50-1:200
  • Western Blot 1:500-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.4, 150mM NaCl, 50% glycerol.
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Thrombomodulin/BDCA-3 Antibody (SR1034) - BSA Free

• BDCA3
• BDCA-3
• CD141 antigen
• CD141
• Fetomodulin
• THBD
• THRM
• Thrombomodulin
• TM

Background

CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: THBD