EPCR Antibody [Unconjugated]


Western blot shows lysates of human skin tissue, human placenta tissue, and HUVEC human umbilical vein endothelial cells. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Human EPCR Antigen ...read more
EPCR was detected in immersion fixed paraffin-embedded sections of human liver using 1.7 µg/mL Goat Anti-Human EPCR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2245) overnight at 4 °C. ...read more

Product Details

Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, CyTOF-ready

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
View Available Formulations
Catalog# & Formulation Size Price

EPCR Antibody [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant human EPCR
Accession # Q9UNN8
Detects human EPCR in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant mouse EPCR is observed.
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
  • Immunohistochemistry 1-15 ug/mL
  • Western Blot 0.25 ug/mL
Read Publications using
AF2245 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for EPCR Antibody [Unconjugated]

  • APC receptor
  • CCCA
  • CCD41
  • CCD41centrosome-associated protein
  • CD201 antigen
  • CD201
  • centrocyclin
  • Endothelial cell protein C receptor
  • endothelial protein C receptor
  • EPCR
  • EPCRMGC23024
  • protein C receptor, endothelial


EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. Protein C is a vitamin K-dependent serine protease that plays a major role in blood coagulation. Binding of Protein C to EPCR leads to the proteolytic activation of PAR1 (protease-activated receptor 1) on endothelial cells and subsequent up-regulation of Protein C-induced genes.  The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for EPCR Antibody (AF2245)(10)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 8 applications: Binding Assay, Dot Blot, ELISA Development, Flow Cytometry, ICC, IHC, IHC-P, Western Blot.

Filter By Application
Binding Assay
Dot Blot
ELISA Development
Flow Cytometry
Western Blot
All Applications
Filter By Species
All Species
Showing Publications 1 - 10 of 10.
Publications using AF2245 Applications Species
L Di Pietro, F Giacalone, E Ragozzino, V Saccone, F Tiberio, M De Bardi, M Picozza, G Borsellino, W Lattanzi, E Guadagni, S Bortolani, G Tasca, E Ricci, O Parolini Non-myogenic mesenchymal cells contribute to muscle degeneration in facioscapulohumeral muscular dystrophy patients Cell Death & Disease, 2022-09-16;13(9):793. 2022-09-16 [PMID: 36114172] (IHC, Human) IHC Human
ML Bochenek, R Gogiraju, S Gro beta mann, J Krug, J Orth, S Reyda, GS Georgiadis, H Spronk, S Konstantin, T Münzel, JH Griffin, PS Wild, C Espinola-K, W Ruf, K Schäfer EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia JCI Insight, 2022-07-22;0(0):. 2022-07-22 [PMID: 35700057] (IHC, Western Blot, Human, Mouse) IHC, Western Blot Human, Mouse
M Avril, M Benjamin, MM Dols, JD Smith Interplay of Plasmodium falciparum and thrombin in brain endothelial barrier disruption Sci Rep, 2019-09-11;9(1):13142. 2019-09-11 [PMID: 31511575] (Flow Cytometry, Human) Flow Cytometry Human
G Ecklu-Mens, RW Olsen, A Bengtsson, MF Ofori, L Hviid, ATR Jensen, Y Adams Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes PLoS ONE, 2018-10-09;13(10):e0204177. 2018-10-09 [PMID: 30300360] (Flow Cytometry, ICC, Human) Flow Cytometry, ICC Human
Y Azasi, G Lindergard, A Ghumra, J Mu, LH Miller, JA Rowe Infected erythrocytes expressing DC13 PfEMP1 differ from recombinant proteins in EPCR-binding function Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):. 2018-01-16 [PMID: 29339517] (Binding Assay, Human) Binding Assay Human
Interaction between Endothelial Protein C Receptor and Intercellular Adhesion Molecule 1 to Mediate Binding of Plasmodium falciparum-Infected Erythrocytes to Endothelial Cells MBio, 2016-07-12;7(4):. 2016-07-12 [PMID: 27406562] (Flow Cytometry, Human) Flow Cytometry Human
Campbell JE, Brummel-Ziedins KE, Butenas S Cellular regulation of blood coagulation: a model for venous stasis. Blood, 2010-09-23;116(26):6082-91. 2010-09-23 [PMID: 20864579] (ICC, Human) ICC Human
Gunawardana CG, Kuk C, Smith CR Comprehensive analysis of conditioned media from ovarian cancer cell lines identifies novel candidate markers of epithelial ovarian cancer. J. Proteome Res., 2009-10-01;8(10):4705-13. 2009-10-01 [PMID: 19663500] (ELISA Development, Human) ELISA Development Human
Ducros E, Berthaut A, Mirshahi SS, Faussat AM, Soria J, Agarwal MK, Mirshahi M Aldosterone modifies hemostasis via upregulation of the protein-C receptor in human vascular endothelium. Biochem. Biophys. Res. Commun., 2008-06-13;373(2):192-6. 2008-06-13 [PMID: 18555797] (Dot Blot, Flow Cytometry, ICC, Human) Dot Blot, Flow Cytometry, ICC Human
Xue M, Campbell D, Jackson CJ Protein C is an autocrine growth factor for human skin keratinocytes. J. Biol. Chem., 2007-02-09;282(18):13610-6. 2007-02-09 [PMID: 17293597] (IHC-P, Human) IHC-P Human

Reviews for EPCR Antibody (AF2245) (0)

There are no reviews for EPCR Antibody (AF2245). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for EPCR Antibody (AF2245) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.
mFluor Violet Conjugated Antibodies

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our EPCR Antibody [Unconjugated] and receive a gift card or discount.


Gene Symbol PROCR