Thrombomodulin/BDCA-3 Products

Description

CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Bioinformatics

Uniprot	P07204 Mouse
Product By Gene ID	7056
Alternate Names	BDCA3 BDCA-3 CD141 antigen CD141 Fetomodulin THBD THRM Thrombomodulin TM

Research Areas for Thrombomodulin/BDCA-3

Find related products by research area and learn more about each of the different research areas below.

Cardiovascular Biology

Related Thrombomodulin/BDCA-3 Blog Posts

Check out the latest blog posts on Thrombomodulin/BDCA-3.

Thrombomodulin - A multifunctional protein with roles in inflammation and coagulation Thrombomodulin, also known as BDCA-3, is a glycosylated transmembrane protein present on the surface of vascular endothelial cells. Thrombomodulin is a high-affinity receptor for thrombin, a key protein in the coagulation cascade. Formation of the...    Read more.

Read more Thrombomodulin/BDCA-3 related blogs.