APC Antibody


Western Blot: APC Antibody [NB100-91662] - Lane1:Hela cell lysate. Lane2:HEK293T cell lysate. Lane3:Rat testis tissue lysate.
Immunocytochemistry/ Immunofluorescence: APC Antibody [NB100-91662] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X PBS + 0.05% Triton-X100. The cells were ...read more
Immunohistochemistry-Paraffin: APC Antibody [NB100-91662] - IHC-P analysis of a formalin fixed paraffin embedded tissue section of human colon cancer xenograft using 1: 50 dilution of APC antibody.
Flow Cytometry: APC Antibody [NB100-91662] - An intracellular stain was performed on HeLa cells with APC Antibody NB100-91662AF488 (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then ...read more
Western Blot: APC Antibody [NB100-91662] - Extracts from COLO205 cells.
Immunohistochemistry-Paraffin: APC Antibody [NB100-91662] - Paraffin-embedded human colon carcinoma tissue.

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-P
1.0 mg/ml

APC Antibody Summary

Synthetic peptide made to the human APC protein (between amino acids 2750-2843) [UniProt P25054].
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1:500-1:1000
  • Flow Cytometry 2-10 ug/million cells
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
310 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1.0 mg/ml
Immunogen affinity purified

Alternate Names for APC Antibody

  • adenomatosis polyposis coli tumor suppressor
  • adenomatosis polyposis coli
  • adenomatous polyposis coli protein
  • adenomatous polyposis coli
  • APC
  • BTPS2
  • Deleted in polyposis 2.5
  • DP2
  • DP2.5DP2
  • DP3
  • FPC
  • GS
  • Min
  • Protein APC


The adenomatous polyposis syndromes, familial adenomatous polyposis(FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length with a molecular weight of 300 kDa, which is frequently mutated in patients suffering from FAP and GS. APC has recently been found to be associated with structural components of intracellular junctions. beta-catenin and gamma-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both beta- and gamma-catenin. Interactions between the cytoskeleton and the APC, E cadherin and beta/gamma catenin complex are mediated by alpha-catenin. Like APC, APC2 contains SAMP domains, which are required for conductin binding. Both APC and APC2 regulate the formation of active beta-catenin-Tcf complexes.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for APC Antibody (NB100-91662). (Showing 1 - 1 of 1 FAQ).

  1. Do you offer cat# NB100-91662 and NB100-1869AF488 labelled with Cy5 or APC ?
    • NB100-1869 is validated for Flow, both types of IHC (frozen and paraffin), and ICC/IF... and already has several conjugates available.https://www.novusbio.com/products/eaat1-glast-1-slc1a3-antibody_nb100-1869. We could add this antibody conjugated to APC or Cy5 into our system if interested. NB100-91662 is not validated for Flow but has been validated for IHC (parrafin only IHC-P)... and already has several conjugates available. We could add both conjugates, but if these are going to be used for Flow it would not be guaranteed.

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 NB100-91662AF350
Alexa Fluor 405 NB100-91662AF405
Alexa Fluor 488 NB100-91662AF488
Alexa Fluor 532 NB100-91662AF532
Alexa Fluor 594 NB100-91662AF594
Alexa Fluor 647 NB100-91662AF647
Alexa Fluor 700 NB100-91662AF700
Alexa Fluor 750 NB100-91662AF750
Biotin NB100-91662B
DyLight 350 NB100-91662UV
DyLight 405 NB100-91662V
DyLight 488 NB100-91662G
DyLight 550 NB100-91662R
DyLight 594 NB100-91662DL594
DyLight 650 NB100-91662C
DyLight 680 NB100-91662FR
DyLight 755 NB100-91662IR
FITC NB100-91662F
HRP NB100-91662H
Janelia Fluor 549 NB100-91662JF549
Janelia Fluor 646 NB100-91662JF646

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Gene Symbol APC