TGF-beta 3 Antibody

Product Discontinued

TGF-beta 3 Antibody Summary

• Immunogen: A synthetic peptide derived from the C-terminus of the precursor form of human TGF beta 3.
• Localization: Cytoplasmic
• Specificity: TGF beta 3. Does not react with TGF beta 1 or TFG beta 2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TGFB3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: IHC-P: Use at a dilution of 1/100 for 10 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at RT for 20 minutes. NB600-1531 demonstrates cytoplasmic staining. Western Blot was reported in scientific literature.
• Control:

  AXUD1 Overexpression Lysate
  Human Placenta Whole Tissue Lysate (Adult Whole Normal)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 10mM PBS (pH 7.4) and BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for TGF-beta 3 Antibody

• ARVD
• ARVD1
• FLJ16571
• LDS5
• RNHF
• TGFB3
• TGFbeta 3
• TGF-beta 3
• TGF-beta3
• TGF-beta-3
• transforming growth factor beta-3
• transforming growth factor, beta 3

Background

Transforming Growth Factor beta 3 (TGF beta 3) is a member of the TGF beta family of growth factors. The TGF beta polypeptides are multifunctional, capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. The multi-modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TGF-beta 3 Antibody (NB600-1531)(3)

Publications using NB600-1531

• Ali, M, Shahin, S M Et al. 1,25 Dihydroxyvitamin D3 Enhances the Antifibroid Effects of Ulipristal Acetate in Human Uterine Fibroids. Reprod Sci 2019-06-01 [PMID: 30514160] (WB, Human)
• Dekker S, van Geemen D, van den Bogaerdt AJ et al. Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves Front Cardiovasc Med 2018-08-15 [PMID: 30159315] (IHC-P, Human)
• Kimura C, Hayashi M, Mizuno Y, Oike M. Endothelium-dependent epithelial-mesenchymal transition of tumor cells: Exclusive roles of transforming growth factor beta1 and beta2. Biochim Biophys Acta 2013-05-10 [PMID: 23668958] (WB, Bovine, Porcine, Human)

Bioinformatics

• Gene Symbol: TGFB3
• Entrez:
  • 21809(Mouse)
  • 25717(Rat)