Recombinant Human/Mouse/Rat BMP-2 Protein


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Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications Bioactivity

Order Details

Recombinant Human/Mouse/Rat BMP-2 Protein Summary

Details of Functionality
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al. (2004) Biochem. Biophys. Res. Commun. 315(2):272. The ED50 for this effect is 40-200 ng/mL.
The specific activity of Recombinant Human BMP-2 is approximately 781 U/μg, which is calibrated against human BMP-2 WHO International Standard (NIBSC code: 93/574).
Chinese Hamster Ovary cell line, CHO-derived
Accession #
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
13 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
15-16 kDa, reducing conditions
Read Publications using
355-BM in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in Glycine, Sucrose, Tween® 80 and Glutamic Acid with BSA as a carrier protein.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 100-200 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human/Mouse/Rat BMP-2 Protein

  • BMP2
  • BMP-2
  • BMP-2A
  • BMP2ABone morphogenetic protein 2A
  • bone morphogenetic protein 2


Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration (1, 2). Human BMP‑2 is synthesized as a 396 amino acid (aa) preproprotein that contains a 23 aa signal sequence, a 259 aa prosegment, and a 114 aa mature region (3). Proteolytic removal of the propeptide enables mature BMP-2 to form active disulfide linked homodimers and heterodimers with BMP-7 (2). Mature monomeric BMP-2 is an 18 kDa glycosylated peptide with seven conserved cysteines that form a cystine knot structure (4). Mature human BMP-2 shares 100% aa sequence identity with mouse and rat BMP-2. It shares 85% aa sequence identity with human BMP-4 and less than 51% with other BMPs. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMPR‑IA, or BMPR‑IB) and a type II receptor (BMP RII or Activin RIIB) (2, 5). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair (6, 7). It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells, and vascular smooth muscle cells (2, 8‑10). BMP-2/BMP-7 heterodimers are significantly more potent than BMP-2 homodimers at inducing bone formation in vivo (11). BMP-2 also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells, and is required for cardiac contractility (12‑15).

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Publications for BMP-2 (355-BM)(102)

We have publications tested in 10 confirmed species: Human, Mouse, Rat, Bovine, Canine, Chicken, Rabbit, Transgenic Mouse, Xenopus, Zebrafish.

We have publications tested in 8 applications: Binding Assay, Bioassay, ELISA capture, In Ovo, In Vivo, In Vivo grafting, Surface Plasmon Resonance, complex formation.

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Binding Assay
ELISA capture
In Ovo
In Vivo
In Vivo grafting
Surface Plasmon Resonance
complex formation
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Showing Publications 1 - 10 of 102. Show All 102 Publications.
Publications using 355-BM Applications Species
MG Perino, S Yamanaka, DR Riordon, Y Tarasova, KR Boheler Ascorbic acid promotes cardiomyogenesis through SMAD1 signaling in differentiating mouse embryonic stem cells PLoS ONE, 2017;12(12):e0188569. 2017 [PMID: 29232368] (Bioassay, Mouse) Bioassay Mouse
Y Yu, S Gu, W Li, C Sun, F Chen, M Xiao, L Wang, D Xu, Y Li, C Ding, Z Xia, Y Li, S Ye, P Xu, B Zhao, J Qin, YG Chen, X Lin, XH Feng Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-? signaling Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):. 2017 [PMID: 28874583] (Bioassay, Mouse) Bioassay Mouse
SJ Bae, HJ Kim, HY Won, YK Min, ES Hwang Acceleration of osteoblast differentiation by a novel osteogenic compound, DMP-PYT, through activation of both the BMP and Wnt pathways Sci Rep, 2017;7(1):8455. 2017 [PMID: 28814721] (Bioassay, Mouse) Bioassay Mouse
J Fan, J Pi-Anfruns, M Guo, DCS Im, ZK Cui, S Kim, BM Wu, TL Aghaloo, M Lee Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2 Sci Rep, 2017;7(1):7518. 2017 [PMID: 28790361] (Bioassay, Human) Bioassay Human
C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells J. Biol. Chem., 2017;0(0):. 2017 [PMID: 28747434] (Bioassay, Human) Bioassay Human
S François, VV Eder, K Belmokhtar, MC Machet, L Douay, NC Gorin, M Benderitte, CA Alain Synergistic effect of human Bone Morphogenic Protein-2 and Mesenchymal Stromal Cells on chronic wounds through hypoxia-inducible factor-1 ? induction Sci Rep, 2017;7(1):4272. 2017 [PMID: 28655873] (Bioassay, Rat) Bioassay Rat
JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson, M Mahe, JE Vallance, NF Shroyer, KL Sinagoga, A Zarzoso-La, JR Hudson, JC Howell, P Chatuvedi, JR Spence, JM Shannon, AM Zorn, MA Helmrath, JM Wells Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling Cell Stem Cell, 2017;0(0):. 2017 [PMID: 28648364] (Bioassay, Human) Bioassay Human
L Bai, HM Chang, JC Cheng, C Klausen, G Chu, PCK Leung, G Yang SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells Cell. Signal., 2017;37(0):52-61. 2017 [PMID: 28578012] (Bioassay, Human) Bioassay Human
YM Lin, J Lee, JFY Lim, M Choolani, JKY Chan, S Reuveny, SKW Oh Critical attributes of human early mesenchymal stromal cell-laden microcarrier constructs for improved chondrogenic differentiation Stem Cell Res Ther, 2017;8(1):93. 2017 [PMID: 28482913] (Bioassay, Human) Bioassay Human
DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney Supraphysiological levels of GDF11 induce striated muscle atrophy EMBO Mol Med, 2017;0(0):. 2017 [PMID: 28270449] (Bioassay, Human) Bioassay Human
Show All 102 Publications.

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FAQs for BMP-2 (355-BM). (Showing 1 - 1 of 1 FAQs).

  1. I am interested in Bone Morphogenic Protein 2 (BMP-2) for clinical trial in humans. I am using this protein in stem cells culture for future use in humans. Do you have BMP-2 in pharma grade that I can use for humans?
    • Our antibodies are for research purposes only unfortunately. I am sorry we cannot be of further help.

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Gene Symbol BMP2