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Synaptopodin Antibody - BSA Free

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Biological Strategies: Western Blot: Synaptopodin Antibody [NBP2-39100] - Representative western blotting results of nephrin and synaptopodin expression level in cultured podocytes as indicates. Image collected ...read more
Immunocytochemistry/ Immunofluorescence: Synaptopodin Antibody [NBP2-39100] - Mouse brain tissue with SYNPO antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: Synaptopodin Antibody [NBP2-39100] - Human brain tissue with SYNPO antibody at 2.5 ug/mL.
Western Blot: Synaptopodin Antibody [NBP2-39100] - Analysis of SYNPO in rat brain tissue lysate with SYNPO antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: Synaptopodin Antibody [NBP2-39100] - Human brain tissue with SYNPO antibody at 20 ug/mL.
Immunohistochemistry: Synaptopodin Antibody [NBP2-39100] - Mouse brain tissue with SYNPO antibody at 5 ug/mL.
Sub-nuclear localization of HIF-1 alpha and HIF-2 alpha . (a) HeLa cells ectopically expressing HIF-1 alpha and HIF-2 alpha EGFP fusions compared with endogenous HIF-1 alpha and HIF-2 alpha labelled using ...read more
Effects of resveratrol on the expression of SIRT1, PGC-1 alpha , HIF-1 alpha and apoptosis proteins in vivo. (A) Activation of the SIRT1–PGC-1 alpha –HIF-1 alpha signaling pathway in PC–AKI associated with DN in ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1 mg/ml
Validated by:
   

Biological Strategies

     

Order Details

Synaptopodin Antibody - BSA Free Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human SYNPO. The immunogen is located within the last 50 amino acids of SYNPO. Amino Acid Squence: SPSRAWSPRAKQAPRPS
Specificity
At least three isoforms of SYNPO are known to exist; this antibody will detect all three isoforms. SYNPO antibody is predicted to not cross-react with other SYNPO family member proteins.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SYNPO
Purity
Peptide affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/mL
  • Immunohistochemistry 2.5 ug/mL
  • Immunohistochemistry-Paraffin 2.5 ug/mL
  • Western Blot 1-2 ug/ml
Theoretical MW
95 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
Synaptopodin Peptide (NBP2-39100PEP)
Publications
Read Publications using
NBP2-39100 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for Synaptopodin Antibody - BSA Free

  • KIAA1029
  • Synaptopodin
  • SYNPO

Background

SYNPO, also known as synaptopodin, is an actin-associated protein in telencephalic dendrites and renal podocytes. SYNPO is tightly associated with the dendritic spine apparatus, and mice lacking the SYNPO gene lack the apparatus. These SYNPO-null mice also demonstrate an impaired ability to express long-term potentiation as well as deficits in spatial memory tasks, indicating that SYNPO is involved in the regulation of synaptic plasticity. Recent studies suggest that SYNPO is linked to neuronal calcium stores and plays a role in the calcium store-associated ability of neurons to undergo long-term plasticity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Synaptopodin Antibody (NBP2-39100)(9)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: ELISA, ICC/IF, IHC-Fr, WB.


Filter By Application
ELISA
(1)
ICC/IF
(4)
IHC-Fr
(1)
WB
(3)
All Applications
Filter By Species
Human
(3)
Mouse
(4)
Rat
(1)
All Species
Showing Publications 1 - 9 of 9.
Publications using NBP2-39100 Applications Species
Yang Q, Wang L, Liang Y et al. Loss of UCP2 causes mitochondrial fragmentation by OMA1-dependent proteolytic processing of OPA1 in podocytes FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023-11-01 [PMID: 37874273] (WB) WB
Chen J. Fine granular deposition of clonal immunoreactivity on podocyte cell bodies: a primary podocytopathy marker and potential clue to disease mechanism. Thesis 1905-07-10 (ICC/IF, Human) ICC/IF Human
Wei M, Qiu Z, Li H et al. Integrating network pharmacology approach and experimental validation to reveal the alleviation of Shenkangning capsule on chronic nephritis Journal of Ethnopharmacology 2022-08-01 [PMID: 36057408] (ELISA, Mouse) ELISA Mouse
Tao Y, Chaudhari S, Shotorbani PY et al. Enhanced Orai1-mediated store-operated Ca2+ channel/calpain signaling contributes to high glucose-induced podocyte injury The Journal of biological chemistry 2022-04-28 [PMID: 35490782] (WB, Human) WB Human
Kulikov AA, Naumova AA, Aleksandrova EP Et al. Audiogenic kindling stimulates aberrant neurogenesis, synaptopodin expression, and mossy fiber sprouting in the hippocampus of rats genetically prone to audiogenic seizures Epilepsy & behavior : E&B 2021-12-01 [PMID: 34837844] (IHC-Fr, Rat) IHC-Fr Rat
Moon SJ, Jeong JY, Kim JH et al. The potential roles of NAD(P)H:quinone oxidoreductase 1 in the development of diabetic nephropathy and actin polymerization Sci Rep 2020-10-20 [PMID: 33082368] (ICC/IF, Mouse) ICC/IF Mouse
Yuan Q, Miao J, Yang Q et al. Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation Cell Death Dis 2020-05-11 [PMID: 32393782] (WB, Mouse) WB Mouse
Li H, Zhang W, Zhong F et al. Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury. kidney Int. 2018-10-23 [PMID: 30366682] (ICC/IF, Human) ICC/IF Human
Chen W, Wu Y, Zhang G et al. GdT Cells Exacerbate Podocyte Injury via the CD28/B7-1-Phosphor-SRC Kinase Pathway Biomed Res Int. [PMID: 29862277] (ICC/IF, Mouse) ICC/IF Mouse

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SYNPO
Uniprot