Western Blot: SUR1 Antibody (S289-16) [NBP2-59320] - Western Blot analysis of Rat Brain Membrane showing detection of ~160 kDa SUR1 protein using Mouse Anti-SUR1 Monoclonal Antibody, Clone S289-16 (NBP2-59320). Lane 1: ...read more
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
HHF1Sulfonylurea receptor 1
sulfonylurea receptor (hyperinsulinemia)
SURATP-binding cassette transporter sub-family C member 8
TNDM2ATP-binding cassette sub-family C member 8
SUR1 is encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Western Blot analysis of mouse pancreatic islets using Mouse Anti-SUR1 S289-16. Lane 1: Molecular Weight Ladder. Lanes 2-5: Samples from pooled pancreatic islets. Load: ~10 ug. Primary Antibody: Anti-SUR1 Monoclonal Antibody at 1:200 for ~16 hours at 4 degrees celsius. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT.
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