Hu, Mu, Rt, HaApplications:
WB, ICC/IF, IHCHost:
WB, IHC, IHC-PHost:
Hu, Mu, Rt, CaApplications:
Applications: WB, ELISA, PA, AP
SUR1 is encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.
|Product By Gene ID
- sulfonylurea receptor (hyperinsulinemia)
- SURATP-binding cassette transporter sub-family C member 8
- TNDM2ATP-binding cassette sub-family C member 8
- HHF1Sulfonylurea receptor 1
- ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Bioinformatics Tool for SUR1
Discover related pathways, diseases and genes to SUR1. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.