Stabilin-2 Antibody (841101) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: IHC
• Clone: 841101
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

Stabilin-2 Antibody (841101) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human Stabilin-2
  Gly2198-Val2295
  Accession # Q8WWQ8
• Specificity: Detects human Stabilin-2 in ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Stabilin-1 or recombinant mouse Stabilin-2 is observed.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Stabilin-2 Antibody (841101) [Alexa Fluor® 700]

• CD44-like precursor FELL
• DKFZP434E0321
• FAS1 EGF-like and X-link domain containing adhesion molecule-2
• FAS1 EGF-like and X-link domain-containing adhesion molecule 2
• fasciclin egf-like, laminin-type egf-like, and link domain-containing scavengerreceptor-2
• Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavengerreceptor 2
• FEEL2
• FEEL-2
• FELE-2
• FELL
• FELL-2
• FEX2
• HARE
• HAREFELL2
• hepatic hyaluronan clearance receptor
• Hyaluronan receptor for endocytosis
• hyaluronic acid receptor for endocytosis
• STAB2
• STAB-2
• stabilin 2
• Stabilin2
• Stabilin-2

Background

Stabilin-2, also known as HARE (hyaluronan receptor for endocytosis) and FEEL-2 (fasciclin, EGF-like, laminin type EGF-like, and link domain containing scavenger receptor 2), is a type I transmembrane multi-domain protein that is the closest homolog of stabilin-1 (1, 2). It is a scavenger receptor that is expressed on sinusoidal endothelial cells of liver, spleen, and lymph node (1, 2). Its 2439 amino acid (aa) extracellular domain contains seven fasciclin domains, multiple EGF-like and laminin type EGF-like domains, and a link domain related to molecules of the TSG-6 superfamily (3). The 72 aa cytoplasmic tail of Stabilin-2 contains a motif that allows the AP2 classical cargo adaptor to direct cargo into clathrin-coated pits (4). As a recycling receptor, Stabilin-2 cycles from the membrane to clathrin-coated pits each 10‑15 minutes, with about two thirds of the protein found within the endocytic system at any one time (4). The link domain binds and mediates the systemic clearance of hyaluronan (HA) (2‑6). Within the link domain (aa 2198‑2295), human Stabilin-2 shares 86% and 89% aa identity with mouse and rat Stabilin-2, respectively. Total human HA is about 15 grams, of which about 5 grams are cleared each day (5). Stabilin-2 also mediates the endocytosis of chondroitin and chondroitin sulfate, advanced glycosylation end-product (AGE), collagen N-terminal propeptides and acetylated LDL (4‑7). Human Stabilin-2 mRNA encodes a 2251 aa, 315 kDa protein that produces an isoform of 190 kDa through proteolytic cleavage (2, 6). The 190 kDa form lacks some N-terminal fasciclin and EGF-like domains, but shows similar activities when compared with the 315 kDa form (2, 6).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q8WWQ8()