Uteroglobin/SCGB1A1 Antibody (394324) [Unconjugated]


Uteroglobin/SCGB1A1 was detected in immersion fixed paraffin-embedded sections of human lung using 15 µg/mL Rat Anti-Human Uteroglobin/SCGB1A1 Monoclonal Antibody (Catalog # MAB4218) overnight at 4 °C. Before ...read more
Uteroglobin/SCGB1A1 was detected in immersion fixed paraffin-embedded sections of human lung using Rat Anti-Human Uteroglobin/SCGB1A1 Monoclonal Antibody (Catalog # MAB4218) at 15 µg/mL overnight at 4 °C. Tissue was ...read more

Product Details

Reactivity HuSpecies Glossary
Applications WB, IHC

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Uteroglobin/SCGB1A1 Antibody (394324) [Unconjugated] Summary

E. coli-derived recombinant human Uteroglobin/SCGB1A1
Accession # P11684
Detects human Uteroglobin/SCGB1A1 in direct ELISAs and Western blots.
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Immunohistochemistry 8-25 ug/mL
  • Western Blot 1 ug/mL
Reviewed Applications
Read 1 Review rated 4
MAB4218 in the following applications:

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MAB4218 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Uteroglobin/SCGB1A1 Antibody (394324) [Unconjugated]

  • Blastokinin
  • CC10
  • CC10Urine protein 1
  • CC16
  • CCSP
  • Clara cell phospholipid-binding protein
  • Clara cells 10 kDa secretory protein
  • Clara
  • PCB-BP
  • SCGB1A1
  • Secretoglobin family 1A member 1
  • secretoglobin, family 1A, member 1 (uteroglobin)
  • UGB
  • UGBUP-1
  • UP1
  • Urinary protein 1
  • Uteroglobin


Uteroglobin, also called Clara cell secretory, phospholipid binding, 10 kDa or 16 kDa protein (CCSP, CCPBP, CC10 or CC16, respectively) is a small, non‑glycosylated secreted protein of the secretoglobin superfamily, (designated 1A, member 1) (1‑3). Its name is derived from its very high expression in the pre‑implantation uterus. It is produced by the non-ciliated, non-mucous secretory cells that predominate in lung bronchioles (Clara cells), and other non-ciliated epithelia that communicate with the external environment (1‑3). Expression is induced by steroid hormones such as estrogen, and enhanced by the non-steroid hormone prolactin (1). Uteroglobin is found in blood, urine and other body fluids (1). Human Uteroglobin cDNA encodes a 21 amino acid (aa) signal sequence and a 70 aa mature protein. It shares 53‑56% aa identity with mouse, rat, bovine, canine, equine or rabbit Uteroglobin, and is active in mice (4). The mature protein forms a disulfide-linked head-to-tail homodimer of 16 kDa (2, 5). This homodimer is thought to form a binding pocket that binds hydrophobic ligands such as phospholipids, progesterone and retinols (5). Sequestering of prostaglandins and leukotrienes is anti-inflammatory, while sequestering of carcinogens such as polychlorinated bisphenols is anti-tumorigenic (6‑8). Other immunoregulatory activities of Uteroglobin include cell migration inhibition (by binding the chemotaxis-related formyl peptide receptor FPR2 on dendritic cells), and the inhibition of T cell differentiation to a Th2 phenotype (9). A single nucleotide polymorphism of Uteroglobin, A38G, confers increased risk of asthma (10). Transglutaminase can crosslink Uteroglobin, either to itself or to other proteins such as the adhesion molecule fibronectin (3, 11). Binding of fibronectin to Uteroglobin in the kidney is thought to protect against nephropathy, while binding of the lipocalin-1 receptor has been reported to suppress cancer cell motility and invasion (12, 13).

  1. Mukherjee, A.B. et al. (2007) Endocr. Rev. 28:707.
  2. Singh, G. et al. (1988) Biochim. Biophys. Acta 950:329.
  3. Mantile, G. et al. (1993) J. Biol. Chem. 268:20343.
  4. Wang, S-Z. et al. (2003) J. Immunol. 171:1051.
  5. Umland, T.C. et al. (1994) Nat. Struct. Biol. 1:538.
  6. Mandal, A.K. et al. (2004) J. Exp. Med. 199:1317.
  7. Watson, T.M. et al. (2001) Am. J. Physiol. Lung Cell Mol. Physiol. 281:L1523.
  8. Yang, Y. et al. (2004) J. Biol. Chem. 279:29336.
  9. Ray, R. et al. (2006) FEBS Lett. 580:6022.
  10. Martin, A.C. et al. (2006) Am. J. Respir. Crit. Care Med. 173:617.
  11. Antico, G. et al. (2006) J. Cell Physiol. 207:553.
  12. Zheng, F. et al. (1999) Nat. Med. 5:1018.
  13. Zhang, Z. et al. (2006) Gene 369:66.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Uteroglobin/SCGB1A1 Antibody (MAB4218)(10)

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 3 applications: ICC, ICC/IF, IHC.

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Showing Publications 1 - 10 of 10.
Publications using MAB4218 Applications Species
Lee, W;Lee, S;Yoon, JK;Lee, D;Kim, Y;Han, YB;Kim, R;Moon, S;Park, YJ;Park, K;Cha, B;Choi, J;Kim, J;Ha, NY;Kim, K;Cho, S;Cho, NH;Desai, TJ;Chung, JH;Lee, JH;Kim, JI; A single-cell atlas of in vitro multiculture systems uncovers the in vivo lineage trajectory and cell state in the human lung Experimental & molecular medicine 2023-08-15 [PMID: 37582976] (ICC/IF, Rat) ICC/IF Rat
P Kadur Laks, V Sontake, A Tata, Y Kobayashi, L Macadlo, K Okuda, AS Conchola, S Nakano, S Gregory, LA Miller, JR Spence, JF Engelhardt, RC Boucher, JR Rock, SH Randell, PR Tata Human distal lung maps and lineage hierarchies reveal a bipotent progenitor Nature, 2022-03-30;604(7904):111-119. 2022-03-30 [PMID: 35355018] (ICC, IHC, Human) ICC, IHC Human
R Morgan, C Manfredi, KF Easley, LD Watkins, WR Hunt, SL Goudy, EJ Sorscher, M Koval, SA Molina A medium composition containing normal resting glucose that supports differentiation of primary human airway cells Scientific Reports, 2022-01-27;12(1):1540. 2022-01-27 [PMID: 35087167] (ICC, Human) ICC Human
H Song, HNW Weinstein, P Allegakoen, MH Wadsworth, J Xie, H Yang, EA Castro, KL Lu, BA Stohr, FY Feng, PR Carroll, B Wang, MR Cooperberg, AK Shalek, FW Huang Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states Nature Communications, 2022-01-10;13(1):141. 2022-01-10 [PMID: 35013146] (IHC, Human) IHC Human
JJ Kathiriya, C Wang, M Zhou, A Brumwell, M Cassandras, CJ Le Saux, M Cohen, KD Alysandrat, B Wang, P Wolters, M Matthay, DN Kotton, HA Chapman, T Peng Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells Nature Cell Biology, 2021-12-30;0(0):. 2021-12-30 [PMID: 34969962] (IHC, Human) IHC Human
IT Stancil, JE Michalski, D Davis-Hall, HW Chu, JA Park, CM Magin, IV Yang, BJ Smith, E Dobrinskik, DA Schwartz Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional Nature Communications, 2021-07-27;12(1):4566. 2021-07-27 [PMID: 34315881] (IHC, Human) IHC Human
K Ernst, AK Mittler, V Winkelmann, C Kling, N Eberhardt, A Anastasia, M Sonnabend, R Lochbaum, J Wirsching, M Sakari, AT Pulliainen, C Skerry, NH Carbonetti, M Frick, H Barth Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo Scientific Reports, 2021-03-08;11(1):5429. 2021-03-08 [PMID: 33686161] (ICC, Human) ICC Human
X Yin, L Riva, Y Pu, L Martin-San, J Kanamune, Y Yamamoto, K Sakai, S Gotoh, L Miorin, PD De Jesus, CC Yang, KM Herbert, S Yoh, JF Hultquist, A García-Sas, SK Chanda MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells Cell Reports, 2021-01-12;34(2):108628. 2021-01-12 [PMID: 33440148] (ICC, Human) ICC Human
J Youk, T Kim, KV Evans, YI Jeong, Y Hur, SP Hong, JH Kim, K Yi, SY Kim, KJ Na, T Bleazard, HM Kim, M Fellows, KT Mahbubani, K Saeb-Parsy, SY Kim, YT Kim, GY Koh, BS Choi, YS Ju, JH Lee Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2 Cell Stem Cell, 2020-10-21;27(6):905-919.e10. 2020-10-21 [PMID: 33142113] (ICC, Human) ICC Human
MN Ali, M Mori, TCJ Mertens, P Siddhuraj, JS Erjefält, P Önnerfjord, PS Hiemstra, A Egesten Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells Sci Rep, 2019-10-29;9(1):15566. 2019-10-29 [PMID: 31664154] (IHC, Human) IHC Human

Review for Uteroglobin/SCGB1A1 Antibody (MAB4218) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Human.

Reviews using MAB4218:
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Images Ratings Applications Species Date Details
Immunofluorescence Uteroglobin/SCGB1A1 MAB4218
reviewed by:
Veronika Winkelmann
IF Human 11/28/2017


Sample Testedtracheal epithelial cells


CommentsCells were fixed with 4% Paraformaldehyde. Human Uteroglobin/SCGB1A1 Antibody was applied at 20 µg/ml at 4°C overnight. Secondary antibody was Goat-anti-Rat-488 (1/400) and Phalloidin-Alexa Fluor 647 (1/50)

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FAQs for Uteroglobin/SCGB1A1 Antibody (MAB4218). (Showing 1 - 1 of 1 FAQs).

  1. MAB4218 Uteroglobin antibody Can you tell me if it reacts in mouse tissue? 
    • This product has not yet been tested with mouse samples and based on the sequence homology (52%) we do not anticipate this product being able to detect the mouse protein.  If you are looking for a mouse antibody for this target, we have two products that might be better options: NBP2-75705 and NBP2-90517.

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Recent Reviews


Veronika Winkelmann
Application: IF
Species: Human


Gene Symbol SCGB1A1