SR-AI/MSR Antibody

Images

 
Western Blot: SR-AI/MSR Antibody [NBP1-00093] - Detection of Macrophage Scavenger Receptor I in human liver.
Immunocytochemistry/ Immunofluorescence: SR-AI/MSR Antibody [NBP1-00093] - The MSR antibody was tested in Raw cells at a 1:50 dilution against Dylight 488 (Green). Alpha-tubulin and nuclei were counterstained against ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ca, Eq, PmSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

SR-AI/MSR Antibody Summary

Immunogen
Synthetic peptide made to a cyclized peptide from human Macrophage Scavenger Receptor I (within residues 400-450). [Swiss-Prot# P21757]
Localization
Membrane; Single-pass type II membrane protein.
Predicted Species
Rat (92%), Equine (100%), Canine (100%), Bovine (93%), Primate (93%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MSR1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
Application Notes
This Macrophage Scavenger Receptor I antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen ~50 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
Liver Lysate (NB820-59232)
SR-AI/MSR Lysate (NBL1-13335)
Control Peptide
SR-AI/MSR Peptide (NBP1-00093PEP)

Reactivity Notes

Reacts with human and mouse. 100% sequence identity with horse and dog, 93% identity with monkey and bovine, 92% identity with rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS and 30% Glycerol
Preservative
0.1% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SR-AI/MSR Antibody

  • CD204 antigen
  • CD204
  • Macrophage acetylated LDL receptor I and II
  • macrophage scavenger receptor 1
  • macrophage scavenger receptor type III
  • MSR1
  • phSR1
  • phSR2
  • SCARA1
  • SCARA1macrophage scavenger receptor types I and II
  • Scavenger receptor class A member 1
  • scavenger receptor class A, member 1
  • SR-A
  • SRAI
  • SR-AI

Background

Macrophage Scavenger Receptor I (MSR1, also called CD204 or scavenger receptor A) belongs to scavenger receptor A family and represents phagocytic pattern-recognition receptors (PRRs) expressed predominantly on macrophages and dendritic cells. MSR1 is a single-pass type II membrane glycoprotein capable of binding to a wide range of polyanionic ligands (e.g., modified low density lipoproteins, pathogen-derived molecules), and is implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis, innate immune response as well as Alzheimer's disease. MSR1 mediates the endocytosis of a diverse group of macromolecules including modified LDLs, and scavenger receptors MSR1, CD36 and LOX-1 are three main receptors for oxidized LDL on macrophage membrane wherein MSR1/CD36 account for more than 9/10 of the lipid accumulation in macrophages exposed to oxidized LDL. Defects in MSR1 have also been linked to prostate cancer and Barrett esophagus (BE).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

View specific protocols for SR-AI/MSR Antibody (NBP1-00093): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for SR-AI/MSR Antibody (NBP1-00093) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP1-00093AF405
Alexa Fluor 488 Labeled NBP1-00093AF488
Alexa Fluor 647 Labeled NBP1-00093AF647
Alexa Fluor 700 Labeled NBP1-00093AF700
Biotin Labeled NBP1-00093B
DyLight 405 Labeled NBP1-00093V
DyLight 488 Labeled NBP1-00093G
DyLight 550 Labeled NBP1-00093R
DyLight 650 Labeled NBP1-00093C
FITC Labeled NBP1-00093F
HRP Labeled NBP1-00093H

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Bioinformatics

Gene Symbol MSR1
Entrez