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Human CXCL4/PF4 DuoSet ELISA, 15 Plate

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Human CXCL4/PF4 DuoSet ELISA, 15 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
PF4

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY795.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CXCL4/PF4 DuoSet ELISA, 15 Plate

  • chemokine (C-X-C motif) ligand 4
  • C-X-C motif chemokine 4
  • CXCL4
  • CXCL4iroplact
  • Iroplact
  • MGC138298
  • Oncostatin-A
  • PF4
  • PF-4
  • platelet factor 4
  • SCYB4oncostatin-A

Background

CXCL4/PF4 is a secreted chemokine that is expressed by megakaryocytes and restrains the coagulation cascade. It is released by activated platelets and regulates Thrombin/Thrombomodulin complexes, activated Protein C (APC), Coagulation Factor Xa, and Fibrin. The anticoagulant heparin neutralizes CXCL4 procoagulant effects. Complexes of heparin and CXCL4 trigger antibody formation that causes the pathological syndrome HITT. Immunogenic complexes of CXCL4 with Apolipoprotein H contribute to antiphospholipid syndrome (APS). CXCL4 interferes with the proliferative and angiogenic functions of FGF-2 and VEGF. However, it can also exert proinflammatory and pro-atherogenic effects on monocytes, macrophages, and endothelial cells. CXCL4 may signal through CXCR3B in humans.

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Publications for CXCL4/PF4 (DY795)(24)

We have publications tested in 2 confirmed species: Human, Bovine.


Filter By Application
All Applications
Filter By Species
Human
(23)
Bovine
(1)
All Species
Showing Publications 1 - 10 of 24. Show All 24 Publications.
Publications using DY795 Applications Species
Lekva, T;Sundaram, AYF;Roland, MCP;Åsheim, J;Michelsen, AE;Norwitz, ER;Aukrust, P;Gilfillan, GD;Ueland, T; Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia-an exploratory study BMC medicine 2023-11-23 [PMID: 37996819] (Human) Human
J Jiang, X Cong, S Alageel, U Dornseifer, AF Schilling, E Hadjipanay, HG Machens, P Moog In Vitro Comparison of Lymphangiogenic Potential of Hypoxia Preconditioned Serum (HPS) and Platelet-Rich Plasma (PRP) International Journal of Molecular Sciences, 2023-01-19;24(3):. 2023-01-19 [PMID: 36768283] (Human) Human
I Pietrafort, A Butera, L Gaddini, A Mennella, R Palazzo, D Campanile, K Stefananto, V Riccieri, R Lande, L Frasca CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells International Journal of Molecular Sciences, 2022-12-30;24(1):. 2022-12-30 [PMID: 36614095] (Human) Human
MH Schutte, R Kleemann, NM Nota, CM Wiepjes, JM Snabel, G T'Sjoen, A Thijs, M den Heijer The effect of transdermal gender-affirming hormone therapy on markers of inflammation and hemostasis PLoS ONE, 2022-03-15;17(3):e0261312. 2022-03-15 [PMID: 35290388] (Human) Human
PC Duque-Madr, J Velasco-Bo, A Ceballos-M, C López, JU Carmona Intramammary treatment using allogeneic pure platelet-rich plasma in cows with subclinical mastitis caused by Gram-positive bacteria Scientific Reports, 2021-12-09;11(1):23737. 2021-12-09 [PMID: 34887474] (Bovine) Bovine
A Dickhout, DM Kaczor, ACA Heinzmann, SLN Brouns, JWM Heemskerk, MAMJ van Zandvo, RR Koenen Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells International Journal of Molecular Sciences, 2021-07-08;22(14):. 2021-07-08 [PMID: 34298951] (Human) Human
A Dickhout, BME Tullemans, JWM Heemskerk, VLJL Thijssen, MJE Kuijpers, RR Koenen Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro PLoS ONE, 2021-01-07;16(1):e0244736. 2021-01-07 [PMID: 33411760] (Human) Human
MR Cooperberg, JE Cowan, KJ Lindquist, Y Kobayashi, JP Simko, H Bengtsson, K Singh, V Ngo, A Avila, LF Newcomb, M Tretriakov, DW Lin, S Stone, PR Carroll, PL Paris Multiple Tissue Biomarkers Independently and Additively Predict Prostate Cancer Pathology Outcomes Eur Urol, 2020-11-02;0(0):. 2020-11-02 [PMID: 33148472] (Human) Human
CC Lopez Yoma, KT Preissner, B Lorenz, K Stieger Optimizing Measurement of Vascular Endothelial Growth Factor in Small Blood Samples of Premature Infants Sci Rep, 2019-05-01;9(1):6744. 2019-05-01 [PMID: 31043645] (Human) Human
R Lande, EY Lee, R Palazzo, B Marinari, I Pietrafort, GS Santos, Y Mattenberg, F Spadaro, K Stefananto, N Iannace, AM Dufour, M Falchi, M Bianco, E Botti, L Bianchi, M Alvarez, V Riccieri, ME Truchetet, G C L Wong, C Chizzolini, L Frasca CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-? production in systemic sclerosis Nat Commun, 2019-05-01;10(1):1731. 2019-05-01 [PMID: 31043596] (Human) Human
Show All 24 Publications.

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Bioinformatics

Gene Symbol PF4