Human CXCL4/PF4 DuoSet ELISA, 15 Plate

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Human CXCL4/PF4 DuoSet ELISA, 15 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
PF4

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY795.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CXCL4/PF4 DuoSet ELISA, 15 Plate

  • chemokine (C-X-C motif) ligand 4
  • C-X-C motif chemokine 4
  • CXCL4
  • CXCL4iroplact
  • Iroplact
  • MGC138298
  • Oncostatin-A
  • PF4
  • PF-4
  • platelet factor 4
  • SCYB4oncostatin-A

Background

CXCL4/PF4 is a secreted chemokine that is expressed by megakaryocytes and restrains the coagulation cascade. It is released by activated platelets and regulates Thrombin/Thrombomodulin complexes, activated Protein C (APC), Coagulation Factor Xa, and Fibrin. The anticoagulant heparin neutralizes CXCL4 procoagulant effects. Complexes of heparin and CXCL4 trigger antibody formation that causes the pathological syndrome HITT. Immunogenic complexes of CXCL4 with Apolipoprotein H contribute to antiphospholipid syndrome (APS). CXCL4 interferes with the proliferative and angiogenic functions of FGF-2 and VEGF. However, it can also exert proinflammatory and pro-atherogenic effects on monocytes, macrophages, and endothelial cells. CXCL4 may signal through CXCR3B in humans.

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Publications for CXCL4/PF4 (DY795)(15)

We have publications tested in 1 confirmed species: Human.


Filter By Application
All Applications
Filter By Species
Human
(15)
All Species
Showing Publications 1 - 10 of 15. Show All 15 Publications.
Publications using DY795 Applications Species
CC Lopez Yoma, KT Preissner, B Lorenz, K Stieger Optimizing Measurement of Vascular Endothelial Growth Factor in Small Blood Samples of Premature Infants Sci Rep, 2019;9(1):6744. 2019 [PMID: 31043645] (Human) Human
R Lande, EY Lee, R Palazzo, B Marinari, I Pietrafort, GS Santos, Y Mattenberg, F Spadaro, K Stefananto, N Iannace, AM Dufour, M Falchi, M Bianco, E Botti, L Bianchi, M Alvarez, V Riccieri, ME Truchetet, G C L Wong, C Chizzolini, L Frasca CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-? production in systemic sclerosis Nat Commun, 2019;10(1):1731. 2019 [PMID: 31043596] (Human) Human
TG Walsh, A Wersäll, AW Poole Characterisation of the Ral GTPase inhibitor RBC8 in human and mouse platelets Cell. Signal., 2019;0(0):. 2019 [PMID: 30880223] (Human) Human
T Barwari, S Eminaga, U Mayr, R Lu, PC Armstrong, MV Chan, M Sahraei, M Fernández-, T Moreau, J Barallobre, M Lynch, X Yin, C Schulte, F Baig, R Pechlaner, SR Langley, A Zampetaki, P Santer, M Weger, R Plasenzott, M Schosserer, J Grillari, S Kiechl, J Willeit, AM Shah, C Ghevaert, TD Warner, C Fernández-, Y Suárez, M Mayr Inhibition of profibrotic microRNA-21 affects platelets and their releasate JCI Insight, 2018;3(21):. 2018 [PMID: 30385722] (Human) Human
GJ Nieuwenhui, TAJ van den Be, SJL Bakker, MC van den He, MMRF Struys, T Lisman, RA Pol Preemptively and non-preemptively transplanted patients show a comparable hypercoagulable state prior to kidney transplantation compared to living kidney donors PLoS ONE, 2018;13(7):e0200537. 2018 [PMID: 30011293] (Human) Human
CC Mok, S Soliman, LY Ho, FA Mohamed, FI Mohamed, C Mohan Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis Arthritis Res. Ther., 2018;20(1):6. 2018 [PMID: 29325582] (Human) Human
S Sabrkhany, MJE Kuijpers, SMJ van Kuijk, L Sanders, S Pineda, SWM Olde Damin, AC Dingemans, AW Griffioen, MGA Oude Egbri A combination of platelet features allows detection of early-stage cancer Eur. J. Cancer, 2017;80(0):5-13. 2017 [PMID: 28527393] (Human) Human
David M Briscoe Vascular endothelial growth factor A is associated with the subsequent development of moderate or severe cardiac allograft vasculopathy in pediatric heart transplant recipients J. Heart Lung Transplant., 2016;0(0):. 2016 [PMID: 27865734] (Human) Human
Joseph W Jackson Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis PLoS ONE, 2016;11(6):e0157115. 2016 [PMID: 27270236] (Human) Human
L van Bon, AJ Affandi, J Broen, RB Christmann, RJ Marijnisse, L Stawski, GA Farina, G Stifano, AL Mathes, M Cossu, M York, C Collins, M Wenink, R Huijbens, R Hesselstra, T Saxne, M DiMarzio, D Wuttge, SK Agarwal, JD Reveille, S Assassi, M Mayes, Y Deng, JP Drenth, J de Graaf, M den Heijer, CG Kallenberg, M Bijl, A Loof, WB van den Be, LA Joosten, V Smith, F de Keyser, R Scorza, C Lunardi, PL van Riel, M Vonk, W van Heerde, S Meller, B Homey, L Beretta, M Roest, M Trojanowsk, R Lafyatis, TR Radstake Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis N. Engl. J. Med, 2014;370(5):433-43. 2014 [PMID: 24350901] (Human) Human
Show All 15 Publications.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for CXCL4/PF4 (DY795). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

Biotin DY795

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Bioinformatics

Gene Symbol PF4