Western Blot: SR-AI/MSR Antibody [NBP1-00092] - WB detection of Macrophage Scavenger Receptor I (MSR1) protein in the lysate of human liver.
Immunocytochemistry/ Immunofluorescence: SR-AI/MSR Antibody [NBP1-00092] - The MSR antibody was tested in Raw cells at a 1:250 dilution against Dylight 488 (Green). Alpha-tubulin and nuclei were counterstained against ...read more
This Macrophage Scavenger Receptor I antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen ~50 kDa. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.Use in proximity ligation assay reported in scientific literature (PMID 28338748).
50 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Reacts with human and mouse. 100% sequence identity with horse and dog, 93% identity with monkey and bovine, 92% identity with rat.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS and 30% Glycerol
0.1% Sodium Azide
Immunogen affinity purified
Alternate Names for SR-AI/MSR Antibody
Macrophage acetylated LDL receptor I and II
macrophage scavenger receptor 1
macrophage scavenger receptor type III
SCARA1macrophage scavenger receptor types I and II
Scavenger receptor class A member 1
scavenger receptor class A, member 1
Macrophage Scavenger Receptor I (MSR1, also called CD204 or scavenger receptor A) belongs to scavenger receptor A family and represents phagocytic pattern-recognition receptors (PRRs) expressed predominantly on macrophages and dendritic cells. MSR1 is a single-pass type II membrane glycoprotein capable of binding to a wide range of polyanionic ligands (e.g., modified low density lipoproteins, pathogen-derived molecules), and is implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis, innate immune response as well as Alzheimer's disease. MSR1 mediates the endocytosis of a diverse group of macromolecules including modified LDLs, and scavenger receptors MSR1, CD36 and LOX-1 are three main receptors for oxidized LDL on macrophage membrane wherein MSR1/CD36 account for more than 9/10 of the lipid accumulation in macrophages exposed to oxidized LDL. Defects in MSR1 have also been linked to prostate cancer and Barrett esophagus (BE).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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