Spi-B Antibody

Images

 
Western Blot: SPIB Antibody [NBP1-70345] - Analysis of Spi-B in human Daudi lysate in the 1) absence and 2) presence of immunizing peptide and 3) on mouse RAW lysate using Spi-B polyclonal antibody at 4 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Bv, Ca, Eq, PmSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Spi-B Antibody Summary

Immunogen
A portion of amino acid 15-65 of human Spi-B was used as the immunogen.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SPIB
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 3-5 ug/ml

Reactivity Notes

Reacts in Chimpanzee, Cow, Dog, Horse, Human, Mouse, New World monkey and Orangutan. Predicted to react in Lizard. The amino acid sequence used as immunogen is 100% homologous in human, new world monkey, chimpanzee, cow, orangutan, rhesus monkey, wild pig, 94% homologous in panda, 89% homologous in dog, horse, 82% homologous in mouse, rat and 52% homologous in lizard.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A purified

Alternate Names for Spi-B Antibody

  • Spi-B transcription factor (Spi-1/PU.1 related)
  • SpiB
  • Spi-B
  • transcription factor Spi-B

Background

Transcription factor Spi-B belongs to the ETS family and contains one ETS DNA-binding domain. Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression, thus maintains activity of germinal center and memory B cells by direct repression of major plasma cell factors and thereby plasma cell differentiation. It is reported that Spi-B regulates Progressive multifocal leukoencephalopathy (PML) causing JCVirus gene expression, and may play an important role in JCV activity in the immune and nervous systems. It is also reported Spi-B is expressed in various murine and hematopoietic lines except T lymphoid lines.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NBP2-27163
Species: Hu, Mu, Bv, Ca, Eq, Pm
Applications: WB, Flow
NBP2-22169
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
NBP1-80288
Species: Mu
Applications: WB
NB600-1071
Species: Mu, Rt
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
NBP1-92684
Species: Hu, Mu, Rt, Po, Bv
Applications: WB, ICC/IF
AF5117
Species: Hu
Applications: WB, IHC
NBP1-19097
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP, PLA
NB100-381
Species: Hu
Applications: WB, ChIP, IP, PLA
AF1356
Species: Hu, Mu
Applications: WB, Simple Western, Flow, IHC, CyTOF-ready
AF3487
Species: Hu
Applications: WB, IHC, ICC
NBP1-74190
Species: Mu
Applications: WB, ChIP
NB600-235
Species: Hu, Mu, Po
Applications: WB, ChIP, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
NBP2-37576
Species: Hu, Mu, Pm
Applications: WB, ELISA, Flow, ICC/IF, IHC
H00006934-M06
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC-P
NB600-233
Species: Hu, Mu
Applications: WB, IHC, IHC-P, IP, PLA
AF603
Species: Mu
Applications: WB, Block, ICC
NBP2-45374
Species: Hu
Applications: WB, IHC
NBP1-70345
Species: Hu, Mu, Bv, Ca, Eq, Pm
Applications: WB
Supplier Logo

Publications for Spi-B Antibody (NBP1-70345) (0)

There are no publications for Spi-B Antibody (NBP1-70345).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Spi-B Antibody (NBP1-70345) (0)

There are no reviews for Spi-B Antibody (NBP1-70345). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Spi-B Antibody (NBP1-70345) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Spi-B Products

Bioinformatics Tool for Spi-B Antibody (NBP1-70345)

Discover related pathways, diseases and genes to Spi-B Antibody (NBP1-70345). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Spi-B Antibody (NBP1-70345)

Discover more about diseases related to Spi-B Antibody (NBP1-70345).
 

Pathways for Spi-B Antibody (NBP1-70345)

View related products by pathway.

PTMs for Spi-B Antibody (NBP1-70345)

Learn more about PTMs related to Spi-B Antibody (NBP1-70345).

Blogs on Spi-B

There are no specific blogs for Spi-B, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Spi-B Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol SPIB
Entrez
Uniprot