Transcription factor PU.1 belongs to the ETS family and contains one ETS DNA-binding domain. It is a novel caspase-3 substrate and found to contribute partially chemotherapeutic agents-induced apoptosis in leukemic cellsThis protein is also reported to activate gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. It is found to be one of the key regulators of hematopoitic cell development and induces apoptosis in myeloma cells through direct transactivation of an apoptosis-related gene, tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.