SOX17 Antibody [NL557]

• Reactivity: Hu
• Applications: ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: NL557

SOX17 Antibody [NL557] Summary

• Specificity: Detects human SOX17 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) SOX2, rhSOX6, and rhSOX15 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SOX17

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOX17 Antibody [NL557]

• FLJ22252
• SOX17
• SRY (sex determining region Y)-box 17
• SRY-related HMG-box transcription factor SOX17
• transcription factor SOX-17
• VUR3

Background

SOX17 is a member of the SOX family of transcription factors that bind DNA via a high mobility group (HMG) domain. SOX17 is suggested to play an important role in endoderm development (1, 2). In Western blot, AF1924 detects a 60 kDa band of endogenous SOX17 which is higher than predicted molecular weight but consistent with the current literature (3).

 

1. Kanai-Azuma, M. et al. (2002) Development 129:2367.
2. Katoh, M. et al. (2002) Int. J. Mol. Med. 9:153.
3. Sohn, J. et al. (2006) J. Neuroscience 26:9722.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SOX17 Antibody (NL1924R)(15)

Publications using NL1924R

• Rodrigo M. Florentino, Kazutoyo Morita, Nils Haep, Takashi Motomura, Ricardo Diaz-Aragon, Lanuza A.P. Faccioli et al. Biofabrication of synthetic human liver tissue with advanced programmable functions iScience 2022-12-22 [PMID: 36404924] (Immunohistochemistry, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, VV Thaker Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL Stem Cell Research, 2021-12-23;59(0):102635. 2021-12-23 [PMID: 35074682] (IHC, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, V Thaker Generation of the iPSC line CUIMCi003-A derived from a patient with severe early onset obesity Stem Cell Research, 2021-06-21;54(0):102432. 2021-06-21 [PMID: 34214899] (ICC, Human)
• K Takeishi, A Collin de, Y Wang, K Handa, J Guzman-Lep, K Matsubara, K Morita, S Jang, N Haep, RM Florentino, F Yuan, K Fukumitsu, K Tobita, W Sun, J Franks, ER Delgado, EM Shapiro, NA Fraunhoffe, AW Duncan, H Yagi, T Mashimo, IJ Fox, A Soto-Gutie Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells Cell Rep, 2020-06-02;31(9):107711. 6/2/2020 [PMID: 32492423]
• J Domingo-Pr, V Abad-Moral, M Riera, R Navarro, B Corcostegu, E Pomares Generation of an induced pluripotent stem cell line (FRIMOi007-A) derived from an incomplete achromatopsia patient carrying a novel homozygous mutation in PDE6C gene Stem Cell Res, 2019-09-04;40(0):101569. 2019-09-04 [PMID: 31520890] (ICC, Human)
• J Domingo-Pr, M Riera, V Abad-Moral, S Ruiz-Nogal, B Corcostegu, E Pomares Generation of Best disease-derived induced pluripotent stem cell line (FRIMOi006-A) carrying a novel dominant mutation in BEST1 gene Stem Cell Res, 2019-09-04;40(0):101570. 2019-09-04 [PMID: 31518904] (ICC, Human)
• Collin de l'Hortet A, Takeishi K, Guzman-Lepe J et al. Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism Cell Metab. 8/6/2019 [PMID: 31390551]
• J Domingo-Pr, M Riera, A Burés-Jels, B Corcostegu, E Pomares Establishment of an induced pluripotent stem cell line (FRIMOi005-A) derived from a retinitis pigmentosa patient carrying a dominant mutation in RHO gene Stem Cell Res, 2019-05-22;38(0):101468. 2019-05-22 [PMID: 31146251] (ICC, Human)
• M Riera, A Patel, A Burés-Jels, B Corcostegu, S Chang, E Pomares, B Corneo, JR Sparrow Generation of two iPS cell lines (FRIMOi003-A and FRIMOi004-A) derived from Stargardt patients carrying ABCA4 compound heterozygous mutations Stem Cell Res, 2019-02-13;36(0):101389. 2019-02-13 [PMID: 30798147] (ICC, Human)
• K Filimonow, N Saiz, A Suwi?ska, T Wyszomirsk, JB Grabarek, E Ferretti, A Piliszek, B Plusa, M Maleszewsk No evidence of involvement of E-cadherin in cell fate specification or the segregation of Epi and PrE in mouse blastocysts PLoS ONE, 2019-02-08;14(2):e0212109. 2019-02-08 [PMID: 30735538] (IHC-Fr, Mouse)
• M Riera, A Patel, B Corcostegu, S Chang, B Corneo, JR Sparrow, E Pomares Generation of an induced pluripotent stem cell line (FRIMOi002-A) from a retinitis pigmentosa patient carrying compound heterozygous mutations in USH2A gene Stem Cell Res, 2019-01-17;35(0):101386. 2019-01-17 [PMID: 30685615] (ICC, Human)
• M Riera, A Patel, B Corcostegu, S Chang, JR Sparrow, E Pomares, B Corneo Establishment and characterization of an iPSC line (FRIMOi001-A) derived from a retinitis pigmentosa patient carrying PDE6A mutations Stem Cell Res, 2019-01-17;35(0):101385. 2019-01-17 [PMID: 30685614] (ICC, Human)
• JS Saini, B Corneo, JD Miller, TR Kiehl, Q Wang, NC Boles, TA Blenkinsop, JH Stern, S Temple Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration Cell Stem Cell, 2017-01-26;0(0):. 2017-01-26 [PMID: 28132833] (ICC, Human)
• Kun Zhang, Jocelyn M. Haversat, Jesse Mager CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development Developmental Biology 2013-11-01 [PMID: 24036311]
• Plachta N, Bollenbach T, Pease S Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nat. Cell Biol., 2011-01-23;13(2):117-23. 2011-01-23 [PMID: 21258368] (IHC-Fr, Mouse)

Bioinformatics

• Gene Symbol: SOX17
• Uniprot:
  • Q9H6I2()