SIGIRR Antibody [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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SIGIRR Antibody [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human SIGIRR
Met1-His118
Accession # Q6IA17
Specificity
Detects human SIGIRR in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant human (rh) IL‑1 R9, rhIL-1 R1, rhIL-1 R2, rhIL-1 R3, rhIL-1 R6, rhIL-1 R7, rhIL-1 R8, and rhIL-18 R is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SIGIRR
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF990 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SIGIRR Antibody [Unconjugated]

  • IL-1R8
  • SIGIRR
  • single Ig IL-1-related receptor
  • Single Ig IL-1R-related molecule
  • single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
  • single immunoglobulin domain IL1R1 related
  • Single immunoglobulin domain-containing IL1R-related protein
  • TIR8
  • TIR8MGC110992
  • Toll/interleukin-1 receptor 8

Background

The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL1RAPL1), and TIGIRR-1 (IL-1 R9) (1). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Five of the IL-1 R family members (1, 2, 4, 5, and 6) are clustered and localized to chromosome 2. SIGIRR (single Ig domain containing IL-1 receptor-related molecule) is a subtype of the IL-1 R family that differs from the other nine members by having only one Ig domain in its extracellular region. The sequence of human SIGIRR predicts a 410 amino acid (aa) residue transmembrane glycoprotein that lacks signal peptide and contains a 118 aa single Ig extracellular domain, a transmembrane region and a 268 aa cytoplasmic tail with a TIR domain. The cytoplasmic tail of SIGIRR contains a C-terminal extention beyond the TIR domain which is also found in IL1RAPL1, IL-1 R9, and Toll-like receptor family members but absent in other IL-1 receptor family members. SIGIRR is widely expressed and is present in all cells and tissues examined. Mouse and human SIGIRR share 82% amino acid sequence identity. The ligand and signaling mechanism for SIGIRR has not been identified.
  1. Thomassen, E. et al. (1999) Cytokine 11:389.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SIGIRR Antibody (AF990)(4)

We have publications tested in 3 confirmed species: Human, Mouse, Goat.

We have publications tested in 5 applications: Flow Cytometry, ICC, IHC-Fr, IHC-P, Western Blot.


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Flow Cytometry
(1)
ICC
(1)
IHC-Fr
(1)
IHC-P
(1)
Western Blot
(2)
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Human
(3)
Mouse
(1)
Goat
(1)
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Showing Publications 1 - 4 of 4.
Publications using AF990 Applications Species
K Ueno-Shuto, S Kamei, M Hayashi, A Fukuyama, Y Uchida, N Tokutomi, MA Suico, H Kai, T Shuto A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells International Journal of Molecular Sciences, 2022-07-13;23(14):. 2022-07-13 [PMID: 35887095] (Flow Cytometry, Western Blot, Human) Flow Cytometry, Western Blot Human
J Filipe, V Bronzo, G Curone, B Castiglion, D Vigo, B Smith, V Herrera, P Roccabianc, P Moroni, F Riva Staphylococcus aureus intra-mammary infection affects the expression pattern of IL-R8 in goat Comp. Immunol. Microbiol. Infect. Dis., 2019-07-30;66(0):101339. 2019-07-30 [PMID: 31437679] (IHC-P, Goat) IHC-P Goat
Ueno-Shuto K, Kato K, Tasaki Y, Sato M, Sato K, Uchida Y, Sakai H, Ono T, Suico M, Mitsutake K, Tokutomi N, Kai H, Shuto T Lipopolysaccharide decreases single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR) expression by suppressing specificity protein 1 (Sp1) via the Toll-like receptor 4 (TLR4)-p38 pathway in monocytes and neutrophils. J Biol Chem, 2014-05-12;289(26):18097-109. 2014-05-12 [PMID: 24821721] (Western Blot, Human, Mouse) Western Blot Human, Mouse
Khan MA, Steiner TS, Sham HP, Bergstrom KS, Huang JT, Assi K, Salh B, Tai IT, Li X, Vallance BA The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells. J. Immunol., 2010-02-03;184(5):2305-13. 2010-02-03 [PMID: 20130217] (ICC, IHC-Fr, Human) ICC, IHC-Fr Human

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Bioinformatics

Gene Symbol SIGIRR
Uniprot