SIGIRR Products

Antibodies
SIGIRR Antibody
SIGIRR Antibody
NB100-56890
Species: Hu, Mu
Applications: WB
Host: Rabbit Polyclonal
SIGIRR Antibody [Unconjugated ...
SIGIRR Antibody [Unconjugated]
AF1092
Species: Mu
Applications: WB
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
SIGIRR Antibody
SIGIRR Antibody
NBP1-86940
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
SIGIRR Antibody Pair
SIGIRR Antibody Pair
H00059307-PW1
Species: Hu
Applications: WB, IP
Lysates
SIGIRR Overexpression Lysate ...
SIGIRR Overexpression Lysate (Dena...
H00059307-T01
Species: Hu
Applications: WB
SIGIRR Overexpression Lysate ...
SIGIRR Overexpression Lysate (Native)
NBL1-15956
Applications: WB
SIGIRR Overexpression Lysate ...
SIGIRR Overexpression Lysate (Native)
NBP2-09562
Applications: WB
Proteins
SIGIRR Recombinant Protein
SIGIRR Recombinant Protein
H00059307-P01
Species: Hu
Applications: WB, ELISA, PA
SIGIRR Recombinant Protein An ...
SIGIRR Recombinant Protein Antigen
NBP1-86940PEP
Species: Hu
Applications: AC
SIGIRR Peptide
SIGIRR Peptide
NBP1-76599PEP
Species: Mu
Applications: AC
RNAi
SIGIRR RNAi
SIGIRR RNAi
H00059307-R02
Species: Hu

Description

SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 59307
Alternate Names
  • single immunoglobulin domain IL1R1 related
  • Single immunoglobulin domain-containing IL1R-related protein
  • single Ig IL-1-related receptor
  • Single Ig IL-1R-related molecule
  • TIR8MGC110992
  • Toll/interleukin-1 receptor 8
  • single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

PTMs for SIGIRR

Learn more about PTMs related to SIGIRR.

Phosphorylation
Cleavage

Bioinformatics Tool for SIGIRR

Discover related pathways, diseases and genes to SIGIRR. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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