Human ST2/IL-33R DuoSet ELISA, 5 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human ST2/IL-33R DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL1RL1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human ST2/IL-33R DuoSet ELISA, 5 Plate

• DER4
• DER4ST2growth stimulation-expressed
• Fit-1
• IL-1 R4
• IL1R4
• IL-1R4
• IL-1RL1
• IL-33 R
• IL33R
• IL-33R
• interleukin 1 receptor-like 1
• interleukin 1 receptor-related protein
• interleukin-1 receptor-like 1
• Ly84
• MGC32623
• Protein ST2
• ST2
• ST2L
• ST2V
• T1
• T1homolog of mouse growth stimulation-expressed

Background

ST2, also known as IL-1 R4, is a component of the receptor for the proinflammatory cytokine Interleukin-33. The IL-33 receptor additionally includes IL-1 RAcp which also associates with IL-1 RI and IL-1 R rp2/IL-1 R6. A soluble form of ST2 functions as a decoy receptor. IL-33 promotes Th2-biased immune responses, resulting in eosinophilia, mast cell activation, and allergic inflammation. In addition, IL-33 enhances inflammation-associated hypernociception and protects from atherosclerosis and cardiac myocyte hypertrophy. Soluble ST2 is elevated in the serum under inflammatory conditions including allergic asthma, sepsis, trauma, dengue fever, pulmonary disease, and lupus. It is also associated aortic stenosis, congestive cardiomyopathy, and risk of cardiovascular heart failure and death.

Publications for ST2/IL-33R (DY523B-05)(45)

Publications using DY523B-05

• Ohnewein, B;Shomanova, Z;Jirak, P;Paar, V;Topf, A;Pylypenko, L;Schäbinger, M;Volg, F;Hoppe, UC;Pistulli, R;Zagidullin, N;Lichtenauer, M;Motloch, LJ; Dynamics of the Novel Cardiac Biomarkers sST2, H-FABP, GDF-15 and suPAR in HFrEF Patients Undergoing Heart Failure Therapy, a Pilot Study Journal of clinical medicine 2025-08-11 [PMID: 40869494] (Human)
• Fröhling, T;Semo, D;Mirna, M;Paar, V;Shomanova, Z;Motloch, LJ;Rukosujew, A;Sindermann, JR;Lichtenauer, M;Pistulli, R; Novel Biomarkers as Potential Predictors of Decompensated Advanced Chronic Heart Failure-Single Center Study Journal of clinical medicine 2024-11-14 [PMID: 39598008] (Human)
• Tsuji, G;Yumine, A;Kawamura, K;Takemura, M;Kido-Nakahara, M;Yamamura, K;Nakahara, T; Difamilast, a Topical Phosphodiesterase 4 Inhibitor, Produces Soluble ST2 via the AHR-NRF2 Axis in Human Keratinocytes International journal of molecular sciences 2024-07-19 [PMID: 39063153] (Human)
• Cherpaz, M;Meugnier, E;Seillier, G;Pozzi, M;Pierrard, R;Leboube, S;Farhat, F;Vola, M;Obadia, JF;Amaz, C;Chalabreysse, L;May, C;Chanon, S;Brun, C;Givre, L;Bidaux, G;Mewton, N;Derumeaux, G;Bergerot, C;Paillard, M;Thibault, H; Myocardial transcriptomic analysis of diabetic patients with aortic stenosis: key role for mitochondrial calcium signaling Cardiovascular diabetology 2024-07-08 [PMID: 38978010] (Human)
• Dworok, V;Hähnel, V;Bannehr, M;Paar, V;Edlinger, C;Lichtenauer, M;Butter, C;Haase-Fielitz, A; Soluble Suppression of Tumorigenicity 2 (sST2) in Patients with Predominantly Decompensated Right Heart Failure-A Prospective Observational Study Journal of clinical medicine 2023-11-21 [PMID: 38068252] (Human)
• Pan, X;Liu, J;Li, M;Liang, Y;Liu, Z;Lao, M;Fang, M; The association of serum IL-33/ST2 expression with hepatocellular carcinoma Research Square 2023-01-01 [PMID: 37507682] (Human)
• Alehagen, U;Alexander, J;Aaseth, JO;Larsson, A;Svensson, E;Opstad, TB; Effects of an Intervention with Selenium and Coenzyme Q10 on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect-A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial Cells 2023-07-04 [PMID: 37443807] (Human)
• Wang, HZ;Chen, SW;Zhong, YL;Ge, YP;Qiao, ZY;Li, CN;Guo, RT;Zhang, Z;Qiao, CH;Zhu, JM; Anzhen Risk Evaluation System for Acute Aortic Syndrome (AZSCORE-AAS): protocol for a multicentre prospective cohort study in northern China BMJ open 2023-06-07 [PMID: 37286325] (Human)
• Stojkovic, S;Kampf, S;Harkot, O;Nackenhorst, M;Brekalo, M;Huber, K;Hengstenberg, C;Neumayer, C;Wojta, J;Demyanets, S; Soluble ST2 in Patients with Carotid Artery Stenosis-Association with Plaque Morphology and Long-Term Outcome International journal of molecular sciences 2023-05-19 [PMID: 37240352] (Human)
• J Kletzer, S Hecht, S Ramsauer, B Scharinger, R Kaufmann, J Kammler, J Kellermair, K Akbari, H Blessberge, C Steinwende, K Hergan, UC Hoppe, M Lichtenaue, E Boxhammer A Story of PA/BSA and Biomarkers to Diagnose Pulmonary Hypertension in Patients with Severe Aortic Valve Stenosis-The Rise of IGF-BP2 and GDF-15 Journal of cardiovascular development and disease, 2023-01-05;10(1):. 2023-01-05 [PMID: 36661917] (Human)
• A Teo, PY Chia, GK Ramireddi, SKM Khoo, TW Yeo Clinical and prognostic relevance of sST2 in adults with dengue-associated cardiac impairment and severe dengue PloS Neglected Tropical Diseases, 2022-10-13;16(10):e0010864. 2022-10-13 [PMID: 36228040] (Human)
• S Hecht, E Boxhammer, R Kaufmann, B Scharinger, C Reiter, J Kammler, J Kellermair, M Hammerer, H Blessberge, C Steinwende, UC Hoppe, K Hergan, M Lichtenaue CT-Diagnosed Sarcopenia and Cardiovascular Biomarkers in Patients Undergoing Transcatheter Aortic Valve Replacement: Is It Possible to Predict Muscle Loss Based on Laboratory Tests?-A Multicentric Retrospective Analysis Journal of personalized medicine, 2022-09-04;12(9):. 2022-09-04 [PMID: 36143238] (Human)
• A Topf, M Mirna, V Paar, LJ Motloch, N Bacher, M Franz, UC Hoppe, D Kretzschma, M Lichtenaue Differential Diagnosis between Takotsubo Syndrome and Acute Coronary Syndrome-A Prospective Analysis of Novel Cardiovascular Biomarkers for a More Selective Triage Oncogene, 2022-05-25;11(11):. 2022-05-25 [PMID: 35683362] (Human)
• S Levy, AB Kilgallen, CM Korse, MIFJ Oerlemans, JPG Sluijter, LW van Laake, GD Valk, MET Tesselaar Elevated Serotonin and NT-proBNP Levels Predict and Detect Carcinoid Heart Disease in a Large Validation Study Cancers, 2022-05-10;14(10):. 2022-05-10 [PMID: 35625964] (Human)
• ON Mann, CS Kong, ES Lucas, JJ Brosens, AC Hanyaloglu, PJ Brighton Expression and function of the luteinizing hormone choriogonadotropin receptor in human endometrial stromal cells Scientific Reports, 2022-05-21;12(1):8624. 2022-05-21 [PMID: 35597810] (Human)
• K Rasheed, U Moens, B Policastro, JI Johnsen, V Koljonen, H Sihto, WO Lui, B Sveinbjørn The Merkel Cell Polyomavirus T-Antigens and IL-33/ST2-IL1RAcP Axis: Possible Role in Merkel Cell Carcinoma International Journal of Molecular Sciences, 2022-03-28;23(7):. 2022-03-28 [PMID: 35409061] (Human)
• MH Urban, S Stojkovic, S Demyanets, C Hengstenbe, A Valipour, J Wojta, OC Burghuber Soluble ST2 and All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease-A 10-Year Cohort Study Journal of Clinical Medicine, 2021-12-23;11(1):. 2021-12-23 [PMID: 35011794] (Human)
• ICS Dias, SM de Campos-, ELM Vieira, APL Mota, PS Azevedo, VTDS Anício, FC Guimarães, LM Mantovani, BF Cruz, AL Teixeira, JV Salgado Adiponectin and Stnfr2 peripheral levels are associated with cardiovascular risk in patients with schizophrenia Journal of psychiatric research, 2021-11-09;0(0):. 2021-11-09 [PMID: 34785039] (Human)
• R Rezar, V Paar, C Seelmaier, I Pretsch, P Schwaiger, K Kopp, R Kaufmann, TK Felder, E Prinz, G Gemes, R Pistulli, UC Hoppe, B Wernly, M Lichtenaue Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study Scientific Reports, 2021-11-05;11(1):21756. 2021-11-05 [PMID: 34741120] (Human)
• M Griffiths, J Yang, D Vaidya, M Nies, S Brandal, DD Ivy, F Hickey, K Wolter-War, ED Austin, M Mullen, MW Pauciulo, KA Lutz, EB Rosenzweig, R Hirsch, D Yung, WC Nichols, AD Everett Biomarkers of Pulmonary Hypertension Are Altered in Children With Down Syndrome and Pulmonary Hypertension The Journal of pediatrics, 2021-10-21;0(0):. 2021-10-21 [PMID: 34687693] (Human)
• A Topf, M Mirna, N Bacher, V Paar, C Edlinger, LJ Motloch, S Gharibeh, M Bannehr, UC Hoppe, M Lichtenaue The Value of Fetuin-A as a Predictor to Identify Takotsubo Patients at Risk of Cardiovascular Events Journal of cardiovascular development and disease, 2021-10-05;8(10):. 2021-10-05 [PMID: 34677196]
• J Budzianows, J Hiczkiewic, K ?ojewska, E Kawka, R Rutkowski, K Korybalska Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight Journal of Clinical Medicine, 2021-06-18;10(12):. 2021-06-18 [PMID: 34207297] (Human)
• RM Torrente-R, CM Martín, M Gamella, M Pedrero, N Martínez-B, P Navarro, P García de, JM Pingarrón, S Campuzano Electrochemical Immunosensing of ST2: A Checkpoint Target in Cancer Diseases Biosensors, 2021-06-21;11(6):. 2021-06-21 [PMID: 34205541] (Human)
• H Dai, O Penack, A Radujkovic, D Schult, J Majer-Laut, IW Blau, L Bullinger, S Jiang, C Müller-Tid, P Dreger, T Luft Early bilirubinemia after allogeneic stem cell transplantation-an endothelial complication Bone marrow transplantation, 2021-01-30;0(0):. 2021-01-30 [PMID: 33517355] (Human)
• P Jirak, R Pistulli, M Lichtenaue, B Wernly, V Paar, LJ Motloch, R Rezar, C Jung, UC Hoppe, PC Schulze, D Kretzschma, RC Braun-Dull, T Bekfani Expression of the Novel Cardiac Biomarkers sST2, GDF-15, suPAR, and H-FABP in HFpEF Patients Compared to ICM, DCM, and Controls J Clin Med, 2020-04-15;9(4):. 2020-04-15 [PMID: 32326570] (Human)
• S Demyanets, C Kaun, A Kaider, W Speidl, M Prager, S Oravec, P Hohensinne, J Wojta, G Rega-Kaun The pro-inflammatory marker soluble suppression of tumorigenicity-2 (ST2) is reduced especially in diabetic morbidly obese patients undergoing bariatric surgery Cardiovasc Diabetol, 2020-02-26;19(1):26. 2020-02-26 [PMID: 32101157] (Human)
• F Morello, A Bartalucci, M Bironzo, M Santoro, E Pivetta, A Ianniello, F Rumbolo, G Mengozzi, E Lupia Prospective diagnostic accuracy study of plasma soluble ST2 for diagnosis of acute aortic syndromes Sci Rep, 2020-02-20;10(1):3103. 2020-02-20 [PMID: 32080259] (Human)
• A Merz, U Germing, G Kobbe, J Kaivers, A Jauch, A Radujkovic, M Hummel, A Benner, M Merz, P Dreger, T Luft EASIX for prediction of survival in lower-risk myelodysplastic syndromes Blood Cancer J, 2019-11-11;9(11):85. 2019-11-11 [PMID: 31712595] (Human)
• A Radujkovic, L Kordelas, J Krzykalla, A Benner, D Schult, J Majer-Laut, DW Beelen, C Müller-Tid, C Kasperk, P Dreger, T Luft Pre-transplant testosterone and outcome of men after allogeneic stem cell transplantation Haematologica, 2019-07-11;0(0):. 2019-07-11 [PMID: 31296579] (Human)
• S Stojkovic, A Kaider, L Koller, M Brekalo, J Wojta, A Diedrich, S Demyanets, T Pezawas GDF-15 is a better complimentary marker for risk stratification of arrhythmic death in non-ischaemic, dilated cardiomyopathy than soluble ST2 J. Cell. Mol. Med., 2018-02-04;0(0):. 2018-02-04 [PMID: 29397580] (Human)
• Yuan Wang, Xin Tan, Hai Gao, Hui Yuan, Rong Hu, Lixin Jia, Junming Zhu, Lizhong Sun, Hongjia Zhang, Lianjun Huang, Dong Zhao, Pei Gao, Jie Du Magnitude of Soluble ST2 as a Novel Biomarker for Acute Aortic Dissection. Circulation, 2017-11-16;0(0):1524-4539. 2017-11-16 [PMID: 29146682] (Human)
• KA Krychtiuk, S Stojkovic, M Lenz, M Brekalo, K Huber, J Wojta, G Heinz, S Demyanets, WS Speidl Predictive value of low interleukin-33 in critically ill patients Cytokine, 2017-09-30;0(0):. 2017-09-30 [PMID: 28974430] (Human)
• D Díaz-Jimén, L Núñez, M De la Fuen, K Dubois-Cam, H Sepúlveda, M Montecino, A Torres-Riq, P García-Gon, J Chnaiderma, A Vossenkamp, TT MacDonald, D Simian, MJ González, JA Cidlowski, R Quera, MA Hermoso A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis Sci Rep, 2017-08-31;7(1):10180. 2017-08-31 [PMID: 28860510] (Human)
• LM Scott, AH Bryant, A Rees, B Down, RH Jones, CA Thornton Production and regulation of interleukin-1 family cytokines at the materno-fetal interface Cytokine, 2017-07-13;0(0):. 2017-07-13 [PMID: 28712670] (Human)
• M Samuelsson, J Dereke, MK Svensson, M Landin-Ols, M Hillman, on the beh Soluble plasma proteins ST2 and CD163 as early biomarkers of nephropathy in Swedish patients with diabetes, 15-34�years of age: a prospective cohort study Diabetol Metab Syndr, 2017-05-25;9(0):41. 2017-05-25 [PMID: 28559931] (Human)
• GA Queiroz, RS Costa, NM Alcantara-, G Nunes de O, ML Barreto, VL Carneiro, CA Figueiredo IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population Int. J. Immunogenet, 2017-04-01;44(2):51-61. 2017-04-01 [PMID: 28266165] (Human)
• Frampton , John P, White , Joshua B, Simon , Arlyne B, Tsuei , Michael, Paczesny , Sophie, Takayama , Shuichi Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA. Sci Rep, 2014-05-02;4(0):4878. 2014-05-02 [PMID: 24786974] (Human)
• Miller A, Purves D, McConnachie A, Asquith D, Batty G, Burns H, Cavanagh J, Ford I, McLean J, Packard C, Shiels P, Turner H, Velupillai Y, Deans K, Welsh P, McInnes I, Sattar N Soluble ST2 Associates with Diabetes but Not Established Cardiovascular Risk Factors: A New Inflammatory Pathway of Relevance to Diabetes? PLoS ONE, 2012-10-24;7(10):e47830. 2012-10-24 [PMID: 23112853] (Human)
• Sahlander K, Larsson K, Palmberg L Daily exposure to dust alters innate immunity. PLoS ONE, 2012-02-15;7(2):e31646. 2012-02-15 [PMID: 22355383] (Human)
• Hong YS, Moon SJ, Moon S, Joo YB, Joo Y, Jeon CH, Jeon C, Cho ML, Ju JH, Oh HJ, Heo YJ, Heo Y, Park SH, Kim HY, Min JK Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis. J Korean Med Sci, 2011-09-01;26(9):1132-9. 2011-09-01 [PMID: 21935266] (Human)
• Rechardt M, Shiri R, Matikainen S, Viikari-Juntura E, Karppinen J, Alenius H Soluble IL-1RII and IL-18 are associated with incipient upper extremity soft tissue disorders. Cytokine, 2011-03-02;54(2):149-53. 2011-03-02 [PMID: 21371906] (Human)
• Mildner M, Storka A, Lichtenauer M Primary sources and immunological prerequisites for sST2 secretion in humans. Cardiovasc. Res., 2010-04-02;87(4):769-77. 2010-04-02 [PMID: 20363761] (Human)
• Weir RA, Miller AM, Murphy GE, Clements S, Steedman T, Connell JM, McInnes IB, Dargie HJ, McMurray JJ Serum soluble ST2: a potential novel mediator in left ventricular and infarct remodeling after acute myocardial infarction. J. Am. Coll. Cardiol., 2010-01-19;55(3):243-50. 2010-01-19 [PMID: 20117403] (Human)
• Bruneau S, Le Berre L, Herve C, Valanciute A, Kamal M, Naulet J, Tesson L, Foucher Y, Soulillou JP, Sahali D, Dantal J Potential role of soluble ST2 protein in idiopathic nephrotic syndrome recurrence following kidney transplantation. Am. J. Kidney Dis., 2009-06-10;54(3):522-32. 2009-06-10 [PMID: 19520469] (Human)
• van 't Veer C, van den Pangaart PS, van Zoelen MA, de Kruif M, Birjmohun RS, Stroes ES, de Vos AF, van der Poll T Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model. J. Immunol., 2007-11-15;179(10):7110-20. 2007-11-15 [PMID: 17982103] (Human)

FAQs for ST2/IL-33R (DY523B-05). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: IL1RL1