Serpin A1/alpha 1-Antitrypsin Antibody (3B7) - BSA Free

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 3B7
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

Serpin A1/alpha 1-Antitrypsin Antibody (3B7) - BSA Free Summary

• Immunogen: a1- AT isolated from human plasma
• Specificity: a1-antitrypsin (human, native and denatured)
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: SERPINA1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:15000
  • Sandwich ELISA
  • Western Blot 1:100-1:2000
• Application Notes: Use in S-ELISA reported in scientific literature (PMID:34276045).

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: 10mM Phosphate (pH 7.4) and 0.5M NaCl
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A or G purified

Alternate Names for Serpin A1/alpha 1-Antitrypsin Antibody (3B7) - BSA Free

• A1A
• A1AT
• AATMGC23330
• alpha 1-Antitrypsin
• alpha 1-Proteinase Inhibitor
• Alpha-1 protease inhibitor
• Alpha-1-antiproteinase
• alpha-1-antitrypsin
• antitrypsin), member 1
• member 1
• PIMGC9222
• serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
• serine (or cysteine) proteinase inhibitor, clade A, member 1
• Serpin A1
• serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

Background

The serum glycoprotein a1-antitrypsin also called a1- AT, is a typical member of the serpin family (serine protease inhibitors), and, an inhibitor of trypsin. a1- AT is synthesized in the liver thus as a single polypeptide chain of approximately 51 kDa showing a marked degree of genetic polymorphism due to the presence of over 20 different alleles. Individuals homozygous for a1- AT deficiency are predisposed to pulmonary emphysema and hepatic cirrhosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Serpin A1/alpha 1-Antitrypsin Antibody (NBP1-05147)(1)

Publication using NBP1-05147

• Janosz E, Hetzel M, Spielmann H Et Al. Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo Gene therapy 2021-07-19 [PMID: 34276045] (S-ELISA)

Bioinformatics

• Gene Symbol: SERPINA1