Semaphorin 6A Antibody [Biotin]

Images

 
There are currently no images for Semaphorin 6A Antibody (BAF1146).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Biotin
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
View Available Formulations

Semaphorin 6A Antibody [Biotin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Semaphorin 6A
Gly19-Thr649
Accession # Q9H2E6
Specificity
Detects human Semaphorin 6A in Western blots. In this format, approximately 50% cross‑reactivity with recombinant mouse (rm) Semaphorin 6A is observed and 5% cross-reactivity with rmSemaphorin 3F is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SEMA6A
Purity
Antigen Affinity-purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Purity
Antigen Affinity-purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Semaphorin 6A Antibody [Biotin]

  • KIAA1368HT018
  • sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
  • Sema VIA
  • SEMA
  • Sema6A
  • SEMA6A1
  • SEMA6A-1
  • Semaphorin 6A
  • semaphorin 6A-1
  • Semaphorin VIA
  • semaphorin-6A
  • semaphorin-6A-1
  • SEMAQ
  • VIA

Background

The semaphorins constitute a large family of secreted, glycosylphosphatidylinositol (GPI)-anchored and transmembrane cell signaling molecules. Depending on their domain organization and species origin, these proteins can be classified into eight groups. To date, at least 19 vertebrate Semaphorins belonging to five groups (class 3 to 7), have been identified. All Semaphorins contain a conserved 500 amino acid (aa) Sema domain at the amino-terminus. Semaphorins are best known for their roles in axon guidance during neuronal development. They are also expressed in non-neuronal tissues and are involved in angiogenesis, hematopoiesis, organogenesis, and the regulation of immune functions (1, 2). Class 6 Semaphorins (Sema 6) are transmembrane proteins that share homology with the axon-guiding insect Sema 1A. Human Sema 6A (VIa) cDNA predicts a 1,030 aa protein comprised of an extracellular domain, a transmembrane domain, and a long cytoplasmic tail (3, 4). A secreted form of Sema 6A can repel sympathetic and dorsal root ganglion axons in vitro, indicating a traditional role as an axon guidance signal (5). There is evidence, however, that Sema 6A also functions as a guidance receptor. Sema 6A mutants show a defect in thalamocortical neuron projection that is cell autonomous, and the cytoplasmic tails for Sema 6 contain binding sites for intracellular regulatory molecules such as Evl and Src (6).

  1. Fiore, R. and A.W. Puschel (2003) Frontiers Biosci. 8:484.
  2. Goshima, Y. et al. (2002) J. Clin. Invest. 109:993.
  3. Zhou, et al. (1997) Mol. Cell Neurosci. 9:26.
  4. Kikuchi, K. et al. (1999) Mol. Cell Neurosci. 13:9.
  5. Xu, X-M. et al. (2000) J. Neurosci. 20:2638.
  6. Leighton, P.A. et al. (2001) Nature 410:174.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Semaphorin 6A Antibody (BAF1146) (0)

There are no publications for Semaphorin 6A Antibody (BAF1146).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Semaphorin 6A Antibody (BAF1146) (0)

There are no reviews for Semaphorin 6A Antibody (BAF1146). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Semaphorin 6A Antibody (BAF1146) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.
mFluor Violet Conjugated Antibodies

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Semaphorin 6A Antibody [Biotin] and receive a gift card or discount.

Bioinformatics

Gene Symbol SEMA6A
Uniprot