Semaphorin 6A Antibody [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, CyTOF-ready
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Conjugate Size Price
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Catalog# & Formulation Size Price

Semaphorin 6A Antibody [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Semaphorin 6A
Gly19-Thr649
Accession # Q9H2E6
Specificity
Detects human Semaphorin 6A in direct ELISAs and Western blots. In direct ELISAs, approximately 40% cross-reactivity with recombinant mouse Semaphorin 6A is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SEMA6A
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Flow Cytometry 2.5 ug/10^6 cells
  • Immunohistochemistry 5-15 ug/mL
  • CyTOF-ready
Publications
Read Publications using
AF1146 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Semaphorin 6A Antibody [Unconjugated]

  • KIAA1368HT018
  • sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
  • Sema VIA
  • SEMA
  • Sema6A
  • SEMA6A1
  • SEMA6A-1
  • Semaphorin 6A
  • semaphorin 6A-1
  • Semaphorin VIA
  • semaphorin-6A
  • semaphorin-6A-1
  • SEMAQ
  • VIA

Background

The semaphorins constitute a large family of secreted, glycosylphosphatidylinositol (GPI)-anchored and transmembrane cell signaling molecules. Depending on their domain organization and species origin, these proteins can be classified into eight groups. To date, at least 19 vertebrate Semaphorins belonging to five groups (class 3 to 7), have been identified. All Semaphorins contain a conserved 500 amino acid (aa) Sema domain at the amino-terminus. Semaphorins are best known for their roles in axon guidance during neuronal development. They are also expressed in non-neuronal tissues and are involved in angiogenesis, hematopoiesis, organogenesis, and the regulation of immune functions (1, 2). Class 6 Semaphorins (Sema 6) are transmembrane proteins that share homology with the axon-guiding insect Sema 1A. Human Sema 6A (VIa) cDNA predicts a 1,030 aa protein comprised of an extracellular domain, a transmembrane domain, and a long cytoplasmic tail (3, 4). A secreted form of Sema 6A can repel sympathetic and dorsal root ganglion axons in vitro, indicating a traditional role as an axon guidance signal (5). There is evidence, however, that Sema 6A also functions as a guidance receptor. Sema 6A mutants show a defect in thalamocortical neuron projection that is cell autonomous, and the cytoplasmic tails for Sema 6 contain binding sites for intracellular regulatory molecules such as Evl and Src (6).

  1. Fiore, R. and A.W. Puschel (2003) Frontiers Biosci. 8:484.
  2. Goshima, Y. et al. (2002) J. Clin. Invest. 109:993.
  3. Zhou, et al. (1997) Mol. Cell Neurosci. 9:26.
  4. Kikuchi, K. et al. (1999) Mol. Cell Neurosci. 13:9.
  5. Xu, X-M. et al. (2000) J. Neurosci. 20:2638.
  6. Leighton, P.A. et al. (2001) Nature 410:174.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Semaphorin 6A Antibody (AF1146)(4)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC, Western Blot.


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ICC
(1)
Western Blot
(3)
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(4)
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Video Protocols

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Secondary Antibodies

 

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Other Available Formats

Biotin BAF1146

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Bioinformatics

Gene Symbol SEMA6A
Uniprot