Please see the vial label for concentration. If unlisted please contact technical services.
Immunogen affinity purified
This RUNX2 antibody is useful for ICC/IF and Immunohistochemistry-paraffin embedded sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Read Publication using NBP1-77461G in the following applications:
Alternate Names for RUNX2/CBFA1 Antibody [DyLight 488]
Acute myeloid leukemia 3 protein
Core-binding factor subunit alpha-1
runt domain, alpha subunit 1
runt-related transcription factor 2
SL3/AKV core-binding factor alpha A subunit
SL3-3 enhancer factor 1 alpha A subunit
RUNX2 is a transcription factor that mediates the expression several downstream proteins, which affect osteoblast differentiation and mitotic progression. It also is important in monocyte activation, as it is upregulated in response to LPS infection. Through interaction with Twist 1 and Twist 2, RUNX2 regulates osteocalcin transcription, following parathyroid hormone signaling for bone loss repair. Ossification in skeletal formation is also partially regulated through RUNX2. Essentially, this transcription factor is responsible for many developmental and repair mechanisms in bone and collagen.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for RUNX2/CBFA1 Antibody (NBP1-77461G). (Showing 1 - 1 of 1 FAQ).
We would like an anti-RUNX2 for IHC-P which share cross reactivity with Rat, but not with Human.
We don't have any data for our RUNX2 antibodies that confirms they will NOT detect the human protein. When we can confirm that an antibody will not react with a certain species, we display a (-) sign on the datasheet. Otherwise, if the species is not listed it means that it has not been tested.