Human Osteoprotegerin/TNFRSF11B DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Osteoprotegerin/TNFRSF11B DuoSet ELISA, 15 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TNFRSF11B

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Osteoprotegerin/TNFRSF11B DuoSet ELISA, 15 Plate

• OCIF
• OCIFMGC29565
• OPG
• OPGtumor necrosis factor receptor superfamily member 11B
• Osteoclastogenesis inhibitory factor
• Osteoprotegerin
• TNFRSF11B
• TR1
• tumor necrosis factor receptor superfamily, member 11b

Background

Osteoprotegerin (OPG), also known as OCIF and TNFRSF11B, is a secreted TNF superfamily receptor that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts, and endothelial cells. OPG functions as a decoy receptor for TRANCE/RANK L and TRAIL. OPG regulates the cell surface expression of TRANCE and its ability to stimulate osteoclastogenesis. Dysregulation of OPG/TRANCE interactions can lead to juvenile Paget’s disease, osteoporosis, bone loss, and vascular calcification.

Publications for Osteoprotegerin/TNFRSF11B (DY805)(82)

Publications using DY805

• KEC Blokland, M Nizamoglu, H Habibie, T Borghuis, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts Frontiers in Pharmacology, 2022-11-03;13(0):989169. 2022-11-03 [PMID: 36408252] (Human)
• T Nicholson, L Davis, ET Davis, M Newton Ede, A Scott, SW Jones e-Cigarette Vapour Condensate Reduces Viability and Impairs Function of Human Osteoblasts, in Part, via a Nicotine Dependent Mechanism Toxics, 2022-08-28;10(9):. 2022-08-28 [PMID: 36136470] (Human)
• R Galla, S Ruga, S Aprile, S Ferrari, A Brovero, G Grosa, C Molinari, F Uberti New Hyaluronic Acid from Plant Origin to Improve Joint Protection-An In Vitro Study International Journal of Molecular Sciences, 2022-07-23;23(15):. 2022-07-23 [PMID: 35897688] (Human)
• J Jiang, L Röper, S Alageel, U Dornseifer, AF Schilling, E Hadjipanay, HG Machens, P Moog Hypoxia Preconditioned Serum (HPS) Promotes Osteoblast Proliferation, Migration and Matrix Deposition Oncogene, 2022-07-07;10(7):. 2022-07-07 [PMID: 35884936] (Human)
• HJ Kim, MS Park, A Joo, S Kang, S Eum, Y Chang, TJ Song Plasma osteoprotegerin level is associated with hemorrhagic transformation in stroke patients who underwent endovascular thrombectomy Clinical neurology and neurosurgery, 2022-05-25;219(0):107305. 2022-05-25 [PMID: 35653867] (Human)
• MS Park, JH Park, A Joo, Y Chang, TJ Song The association of plasma osteoprotegerin levels and functional outcomes post endovascular thrombectomy in acute ischemic stroke patients: a retrospective observational study PeerJ, 2022-05-03;10(0):e13327. 2022-05-03 [PMID: 35529501] (Human)
• S Passaponti, L Ermini, G Acconci, FM Severi, R Romagnoli, S Cutrupi, M Clerico, G Guerrera, F Ietta Rank-Rankl-Opg Axis in Multiple Sclerosis: The Contribution of Placenta Cells, 2022-04-15;11(8):. 2022-04-15 [PMID: 35456036] (Human)
• S Hinkelmann, AH Springwald, S Schulze, U Hempel, F Mitrach, C Wölk, MC Hacker, M Schulz-Sie Mineralizing Gelatin Microparticles as Cell Carrier and Drug Delivery System for siRNA for Bone Tissue Engineering Pharmaceutics, 2022-02-28;14(3):. 2022-02-28 [PMID: 35335924] (Human)
• JW Kennedy, PM Tsimbouri, P Campsie, S Sood, PG Childs, S Reid, PS Young, DRM Meek, CS Goodyear, MJ Dalby Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures Scientific Reports, 2021-11-23;11(1):22741. 2021-11-23 [PMID: 34815449] (Human)
• MS Park, Y Chang, KH Kim, JH Park, TJ Song Plasma osteoprotegerin levels are associated with the presence and burden of cerebral small vessel disease in patients with acute ischemic stroke Clinical neurology and neurosurgery, 2021-10-28;210(0):107010. 2021-10-28 [PMID: 34752988] (Human)
• K Noda, B Dufner, H Ito, K Yoshida, G Balboni, RH Straub Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis Scientific Reports, 2021-09-15;11(1):18399. 2021-09-15 [PMID: 34526577] (Human)
• KEC Blokland, H Habibie, T Borghuis, GJ Teitsma, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM Cells, 2021-06-29;10(7):. 2021-06-29 [PMID: 34209854] (Human)
• BE Barber, MJ Grigg, KA Piera, Y Chen, T William, JB Weinberg, TW Yeo, NM Anstey Endothelial glycocalyx degradation and disease severity in Plasmodium vivax and Plasmodium knowlesi malaria Scientific Reports, 2021-05-07;11(1):9741. 2021-05-07 [PMID: 33963210] (Human)
• B Shetty, DD Divakar, AA Al-Kheraif, AO Alharbi, MST Almutairi, MM Alanazi Role of PDT as an adjunct to SRP on whole salivary RANKL and OPG ratio in type-2 diabetic and normoglycemic individuals with chronic periodontitis Photodiagnosis and photodynamic therapy, 2021-02-18;0(0):102220. 2021-02-18 [PMID: 33610736] (Human)
• GL Marques, S Hayashi, A Bjällmark, M Larsson, M Riella, M Olandoski, B Lindholm, MM Nascimento Osteoprotegerin is a marker of cardiovascular�mortality�in patients with chronic kidney disease stages 3-5 Scientific Reports, 2021-01-28;11(1):2473. 2021-01-28 [PMID: 33510348] (Human)
• HK Pihlstrøm, T Ueland, AE Michelsen, P Aukrust, F Gatti, C Hammarströ, M Kasprzycka, J Wang, G Haraldsen, G Mjøen, DO Dahle, K Midtvedt, IA Eide, A Hartmann, H Holdaas Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients PLoS ONE, 2020-12-16;15(12):e0243759. 2020-12-16 [PMID: 33326471] (Human)
• S Bernardi, B Toffoli, F Tonon, M Francica, E Campagnolo, T Ferretti, S Comar, F Giudici, E Stenner, B Fabris Sex Differences in Proatherogenic Cytokine Levels Int J Mol Sci, 2020-05-29;21(11):. 2020-05-29 [PMID: 32485823] (Human)
• A Adhyatmika, L Beljaars, KSS Putri, H Habibie, CE Boorsma, C Reker-Smit, T Luangmonko, B Guney, A Haak, KA Mangnus, E Post, K Poelstra, K Ravnskjaer, P Olinga, BN Melgert Osteoprotegerin is More than a Possible Serum Marker in Liver Fibrosis: A Study into its Function in Human and Murine Liver Pharmaceutics, 2020-05-21;12(5):. 2020-05-21 [PMID: 32455750] (Human)
• IJ Yeh, SC Chen, MC Yen, YH Wu, CH Hung, PL Kuo 6-Shogaol Suppresses 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b] Pyridine (PhIP)-Induced Human 786-O Renal Cell Carcinoma Osteoclastogenic Activity and Metastatic Potential Nutrients, 2019-09-28;11(10):. 2019-09-28 [PMID: 31569368] (Human)
• S Coufal, N Galanova, L Bajer, Z Gajdarova, D Schierova, Z Jiraskova, K Kostovciko, Z Jackova, Z Stehlikova, P Drastich, H Tlaskalova, M Kverka Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response Cells, 2019-07-13;8(7):. 2019-07-13 [PMID: 31337064] (Human)
• AI Segaliny, JL Cheng, HP Farhoodi, M Toledano, CC Yu, B Tierra, L Hildebrand, L Liu, MJ Liao, J Cho, D Liu, L Sun, G Gulsen, MY Su, RL Sah, W Zhao Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells EBioMedicine, 2019-07-04;45(0):39-57. 2019-07-04 [PMID: 31281099] (Human)
• J Kang, YJ Choi, BY Seo, U Jo, SI Park, YH Kim, KH Park A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment Sci Rep, 2019-06-19;9(1):8726. 2019-06-19 [PMID: 31217507] (Human)
• S Benjakul, C Leethanaku, S Jitpukdeeb Low magnitude high frequency vibration induces RANKL via cyclooxygenase pathway in human periodontal ligament cells in vitro J Oral Biol Craniofac Res, 2019-06-04;9(3):251-255. 2019-06-04 [PMID: 31211043] (Human)
• X Ren, Q Zhou, D Foulad, AS Tiffany, MJ Dewey, D Bischoff, TA Miller, RR Reid, TC He, DT Yamaguchi, BAC Harley, JC Lee Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds Sci Adv, 2019-06-12;5(6):eaaw4991. 2019-06-12 [PMID: 31206025] (Human)
• Y Cao, C Cui, H Zhao, X Pan, W Li, K Wang, A Ma Plasma Osteoprotegerin Correlates with Stroke Severity and the Occurrence of Microembolic Signals in Patients with Acute Ischemic Stroke Dis. Markers, 2019-05-02;2019(0):3090364. 2019-05-02 [PMID: 31191747] (Human)
• C Chatmahamo, A Pravithara, S Suttapreya, C Leethanaku The effect of compressive force combined with mechanical vibration on human alveolar bone osteoblasts J Oral Biol Craniofac Res, 2018-10-16;9(1):81-85. 2018-10-16 [PMID: 30997326] (Human)
• BD Sui, J Chen, XY Zhang, T He, P Zhao, CX Zheng, M Li, CH Hu, Y Jin Gender-independent efficacy of mesenchymal stem cell therapy in sex hormone-deficient bone loss via immunosuppression and resident stem cell recovery Exp. Mol. Med., 2018-12-17;50(12):166. 2018-12-17 [PMID: 30559383] (Human)
• EP McNeill, RW Reese, A Tondon, BH Clough, S Pan, J Froese, D Palmer, U Krause, DM Loeb, R Kaunas, CA Gregory Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition Cell Death Dis, 2018-11-26;9(12):1161. 2018-11-26 [PMID: 30478297] (Human)
• F Sassi, I Buondonno, C Luppi, E Spertino, E Stratta, M Di Stefano, M Ravazzoli, G Isaia, M Trento, P Passera, M Porta, GC Isaia, P D'Amelio Type 2 diabetes affects bone cells precursors and bone turnover BMC Endocr Disord, 2018-08-08;18(1):55. 2018-08-08 [PMID: 30089481] (Human)
• BD Boyan, R Olivares-N, MB Berger, SL Hyzy, Z Schwartz Role of Wnt11 during Osteogenic Differentiation of Human Mesenchymal Stem Cells on Microstructured Titanium Surfaces Sci Rep, 2018-06-05;8(1):8588. 2018-06-05 [PMID: 29872092] (Human)
• E Vorkapic, A Kunath, D Wågsäter Effects of osteoprotegerin/TNFRSF11B in two models of abdominal aortic aneurysms Mol Med Rep, 2018-04-27;0(0):. 2018-04-27 [PMID: 29749489] (Human)
• A A Ochanji, N K Matu, T K Mulli Association of salivary RANKL and osteoprotegerin levels with periodontal health. Clinical and Experimental Dental Research, 2017-04-12;0(0):2057-4347. 2017-04-12 [PMID: 29744178] (Human)
• C Davenport, E Harper, KD Rochfort, H Forde, D Smith, PM Cummins RANKL Inhibits the Production of Osteoprotegerin from Smooth Muscle Cells under Basal Conditions and following Exposure to Cyclic Strain J. Vasc. Res., 2018-04-10;55(2):111-123. 2018-04-10 [PMID: 29635231] (Human)
• F Mizoguchi, K Slowikowsk, K Wei, JL Marshall, DA Rao, SK Chang, HN Nguyen, EH Noss, JD Turner, BE Earp, PE Blazar, J Wright, BP Simmons, LT Donlin, GD Kalliolias, SM Goodman, VP Bykerk, LB Ivashkiv, JA Lederer, N Hacohen, PA Nigrovic, A Filer, CD Buckley, S Raychaudhu, MB Brenner Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis Nat Commun, 2018-02-23;9(1):789. 2018-02-23 [PMID: 29476097] (Human)
• BH Clough, S Zeitouni, U Krause, CD Chaput, LM Cross, AK Gaharwar, CA Gregory Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen-Synthease-Kinase-3-Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo Stem Cells Transl Med, 2018-02-05;0(0):. 2018-02-05 [PMID: 29405665] (ELISA Capture, Human)
• T Ueland, A Åkerblom, T Ghukasyan, AE Michelsen, P Aukrust, RC Becker, M Bertilsson, A Himmelmann, SK James, A Siegbahn, RF Storey, F Kontny, L Wallentin Osteoprotegerin Is Associated With Major Bleeding But Not With Cardiovascular Outcomes in Patients With Acute Coronary Syndromes: Insights From the PLATO (Platelet Inhibition and Patient Outcomes) Trial J Am Heart Assoc, 2018-01-12;7(2):. 2018-01-12 [PMID: 29330256] (Human)
• E Harper, KD Rochfort, H Forde, C Davenport, D Smith, PM Cummins TRAIL attenuates RANKL-mediated osteoblastic signalling in vascular cell mono-culture and co-culture models PLoS ONE, 2017-11-16;12(11):e0188192. 2017-11-16 [PMID: 29145460] (Human)
• S Bernardi, B Toffoli, F Bossi, R Candido, E Stenner, R Carretta, F Barbone, B Fabris Circulating osteoprotegerin is associated with chronic kidney disease in hypertensive patients BMC Nephrol, 2017-07-06;18(1):219. 2017-07-06 [PMID: 28683789] (Human)
• AM Abu El-Asr, S Struyf, G Mohammad, M Gouwy, P Rytinx, MM Siddiquei, C Hernández, K Alam, A Mousa, G De Hertogh, G Opdenakker, R Simó Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy Invest. Ophthalmol. Vis. Sci., 2017-06-01;58(7):3189-3201. 2017-06-01 [PMID: 28654984] (Human)
• M Rogers, N Maldonado-, JD Hutcheson, C Goettsch, S Goto, I Yamada, T Faits, H Sesaki, M Aikawa, E Aikawa Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress Circ. Res., 2017-06-12;0(0):. 2017-06-12 [PMID: 28607103] (Human)
• T Morisawa, A Nakagomi, K Kohashi, Y Kusama, W Shimizu Serum Tartrate-resistant Acid Phosphatase-5b Levels are Associated with the Severity and Extent of Coronary Atherosclerosis in Patients with Coronary Artery Disease J. Atheroscler. Thromb., 2017-04-19;0(0):. 2017-04-19 [PMID: 28428481] (Human)
• ST Chung, D Geerts, K Roseman, A Renaud, L Connelly Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells Mol. Cancer, 2017-02-01;16(1):27. 2017-02-01 [PMID: 28143606] (Human)
• Sang-Hun Shin Effect of low-level laser therapy on bisphosphonate-treated osteoblasts Maxillofac Plast Reconstr Surg, 2016-11-25;38(1):48. 2016-11-25 [PMID: 27995121] (Human)
• Song Yao Bone remodeling and regulating biomarkers in women at the time of breast cancer diagnosis Breast Cancer Res. Treat, 2016-12-03;0(0):. 2016-12-03 [PMID: 27915435] (Human)
• Two Consecutive Days of Crossfit Training Affects Pro and Anti-inflammatory Cytokines and Osteoprotegerin without Impairments in Muscle Power Front Physiol, 2016-06-28;7(0):260. 2016-06-28 [PMID: 27445850] (Human)
• XZ Wang, XY Sun, CY Zhang, X Yang, WJ Yan, LH Ge, SG Zheng RUNX2 Mutation Impairs 1?,25-Dihydroxyvitamin D3 mediated Osteoclastogenesis in Dental Follicle Cells Sci Rep, 2016-04-12;6(0):24225. 2016-04-12 [PMID: 27068678] (Human)
• James S O'Donnell Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria Thromb. Haemost., 2016-01-14;115(4):773-80. 2016-01-14 [PMID: 26766771] (Human)
• Pan X, Pang M, Ma A, Wang K, Zhang Z, Zhong Q, Yang S Association of TRAIL and Its Receptors with Large-Artery Atherosclerotic Stroke. PLoS ONE, 2015-09-03;10(9):e0136414. 2015-09-03 [PMID: 26334877] (Human)
• Lewis J, Lim W, Ueland T, Wong G, Zhu K, Lim E, Bollerslev J, Prince R Elevated Circulating Osteoprotegerin and Renal Dysfunction Predict 15-Year Cardiovascular and All-Cause Mortality: A Prospective Study of Elderly Women. PLoS ONE, 2015-07-29;10(7):e0134266. 2015-07-29 [PMID: 26222774] (Human)
• Chung C, Solus J, Oeser A, Li C, Raggi P, Smith J, Stein C A variant in the osteoprotegerin gene is associated with coronary atherosclerosis in patients with rheumatoid arthritis: results from a candidate gene study. Int J Mol Sci, 2015-02-11;16(2):3885-94. 2015-02-11 [PMID: 25679449] (Human)
• Grisendi G, Spano C, D'souza N, Rasini V, Veronesi E, Prapa M, Petrachi T, Piccinno S, Rossignoli F, Burns J, Fiorcari S, Granchi D, Baldini N, Horwitz E, Guarneri V, Conte P, Paolucci P, Dominici M Mesenchymal progenitors expressing TRAIL induce apoptosis in sarcomas. Stem Cells, 2015-03-01;33(3):859-69. 2015-03-01 [PMID: 25420617] (Human)
• Chen W, Foo S, Taylor A, Lulla A, Merits A, Hueston L, Forwood M, Walsh N, Sims N, Herrero L, Mahalingam S Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection. J Virol, 2014-10-22;89(1):581-93. 2014-10-22 [PMID: 25339772] (Human)
• Davaine J, Quillard T, Brion R, Laperine O, Guyomarch B, Merlini T, Chatelais M, Guilbaud F, Brennan M, Charrier C, Heymann D, Goueffic Y, Heymann M Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stability. PLoS ONE, 2014-09-26;9(9):e107642. 2014-09-26 [PMID: 25259713] (Human)
• Hansen D, Rasmussen K, Rasmussen L, Bruunsgaard H, Brandi L The influence of vitamin D analogs on calcification modulators, N-terminal pro-B-type natriuretic peptide and inflammatory markers in hemodialysis patients: a randomized crossover study. BMC Nephrol, 2014-08-12;15(0):130. 2014-08-12 [PMID: 25112372] (Human)
• Broch K, Askevold E, Gjertsen E, Ueland T, Yndestad A, Godang K, Stueflotten W, Andreassen J, Svendsmark R, Smith H, Aakhus S, Aukrust P, Gullestad L The effect of rosuvastatin on inflammation, matrix turnover and left ventricular remodeling in dilated cardiomyopathy: a randomized, controlled trial. PLoS ONE, 2014-02-25;9(2):e89732. 2014-02-25 [PMID: 24586994] (Human)
• Wulf-Johansson H, Lock Johansson S, Schlosser A, Trommelholt Holm A, Rasmussen L, Mickley H, Diederichsen A, Munkholm H, Poulsen T, Tornoe I, Nielsen V, Marcussen N, Vestbo J, Saekmose S, Holmskov U, Sorensen G Localization of microfibrillar-associated protein 4 (MFAP4) in human tissues: clinical evaluation of serum MFAP4 and its association with various cardiovascular conditions. PLoS ONE, 2013-12-13;8(12):e82243. 2013-12-13 [PMID: 24349233] (Human)
• Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T CCR2+CCR5+ T Cells Produce Matrix Metalloproteinase-9 and Osteopontin in the Pathogenesis of Multiple Sclerosis. J Immunol, 2012-10-15;189(10):5057-65. 2012-10-15 [PMID: 23071279] (Human)
• Chen Y, Wu Y, Yang W, Wang S, Lee C, Chou N, Hsu R, Lin Y, Lin M, Ho Y, Chen M Relationship between bone mineral density and serum osteoprotegerin in patients with chronic heart failure. PLoS ONE, 2012-08-30;7(8):e44242. 2012-08-30 [PMID: 22957004] (Human)
• Rattazzi M, Faggin E, Galliazzo S Osteoprotegerin levels are increased in patients with venous thromboembolic disease. J. Thromb. Haemost., 2012-06-01;10(6):1183-5. 2012-06-01 [PMID: 22486966] (Human)
• Poulsen MK, Nybo M, Dahl J, Hosbond S, Poulsen TS, Johansen A, Hoilund-Carlsen PF, Beck-Nielsen H, Rasmussen LM, Henriksen JE Plasma osteoprotegerin is related to carotid and peripheral arterial disease, but not to myocardial ischemia in type 2 diabetes mellitus. Cardiovasc Diabetol, 2011-08-12;10(0):76. 2011-08-12 [PMID: 21838881] (Human)
• Vik A, Mathiesen EB, Brox J, Wilsgaard T, Njolstad I, Jorgensen L, Hansen JB Serum osteoprotegerin is a predictor for incident cardiovascular disease and mortality in a general population: the Tromso Study. J. Thromb. Haemost., 2011-04-01;9(4):638-44. 2011-04-01 [PMID: 21284802] (Human)
• Olivares-Navarrete R, Hyzy S, Wieland M, Boyan BD, Schwartz Z The roles of Wnt signaling modulators Dickkopf-1 (Dkk1) and Dickkopf-2 (Dkk2) and cell maturation state in osteogenesis on microstructured titanium surfaces. Biomaterials, 2009-12-09;31(8):2015-24. 2009-12-09 [PMID: 20004015] (Human)
• Golledge J, Biros E, Clancy P, Cooper M, Palmer LJ, Norman PE A single-nucleotide polymorphism in the gene encoding osteoprotegerin is associated with diastolic blood pressure in older men. Am. J. Hypertens., 2009-09-24;22(11):1167-70. 2009-09-24 [PMID: 19779468] (Human)
• Eagan TM, Ueland T, Wagner PD, Hardie JA, Mollnes TE, Damas JK, Aukrust P, Bakke PS Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study. Eur. Respir. J., 2009-07-30;35(3):540-8. 2009-07-30 [PMID: 19643942] (Human)
• Clark AK, Yip PK, Malcangio M The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. J. Neurosci., 2009-05-27;29(21):6945-54. 2009-05-27 [PMID: 19474321] (Human)
• Nybo M, Johnsen SP, Dethlefsen C, Overvad K, Tjonneland A, Jorgensen JO, Rasmussen LM Lack of observed association between high plasma osteoprotegerin concentrations and ischemic stroke risk in a healthy population. Clin. Chem., 2008-10-30;54(12):1969-74. 2008-10-30 [PMID: 19042987] (Human)
• Secchiero P, Lamberti G, Corallini F, Melloni E, Guarnotta C, Sebastiani A, Zauli G Conjunctival sac fluid contains elevated levels of soluble TRAIL: implications for the anti-tumoral surveillance of the anterior surface of the eye. J. Cell. Physiol., 2009-01-01;218(1):199-204. 2009-01-01 [PMID: 18780288] (Human)
• Jorsal A, Tarnow L, Flyvbjerg A, Parving HH, Rossing P, Rasmussen LM Plasma osteoprotegerin levels predict cardiovascular and all-cause mortality and deterioration of kidney function in type 1 diabetic patients with nephropathy. Diabetologia, 2008-08-22;51(11):2100-7. 2008-08-22 [PMID: 18719882] (Human)
• Granchi D, Baglio SR, Amato I, Giunti A, Baldini N Paracrine inhibition of osteoblast differentiation induced by neuroblastoma cells. Int. J. Cancer, 2008-10-01;123(7):1526-35. 2008-10-01 [PMID: 18623132] (Human)
• Nybo M, Rasmussen LM Osteoprotegerin released from the vascular wall by heparin mainly derives from vascular smooth muscle cells. Atherosclerosis, 2008-04-15;0(0):. 2008-04-15 [PMID: 18490020] (Human)
• Raje N, Woo SB, Hande K, Yap JT, Richardson PG, Vallet S, Treister N, Hideshima T, Sheehy N, Chhetri S, Connell B, Xie W, Tai YT, Szot-Barnes A, Tian M, Schlossman RL, Weller E, Munshi NC, Van Den Abbeele AD, Anderson KC Clinical, radiographic, and biochemical characterization of multiple myeloma patients with osteonecrosis of the jaw. Clin. Cancer Res., 2008-04-15;14(8):2387-95. 2008-04-15 [PMID: 18413829] (Human)
• Locklin RM, Federici E, Espina B, Hulley PA, Russell RG, Edwards CM Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis. Mol. Cancer Ther., 2007-12-07;6(12):3219-28. 2007-12-07 [PMID: 18065493] (Human)
• Vestergaard ET, Andersen NH, Hansen TK, Rasmussen LM, Moller N, Sorensen KE, Sloth E, Jorgensen JO Cardiovascular effects of intravenous ghrelin infusion in healthy young men. Am. J. Physiol. Heart Circ. Physiol., 2007-09-14;293(5):H3020-6. 2007-09-14 [PMID: 17873022] (Human)
• Lamoureux F, Richard P, Wittrant Y, Battaglia S, Pilet P, Trichet V, Blanchard F, Gouin F, Pitard B, Heymann D, Redini F Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption. Cancer Res., 2007-08-01;67(15):7308-18. 2007-08-01 [PMID: 17671200] (Mouse)
• Kiechl S, Schett G, Schwaiger J, Seppi K, Eder P, Egger G, Santer P, Mayr A, Xu Q, Willeit J Soluble receptor activator of nuclear factor-kappa B ligand and risk for cardiovascular disease. Circulation, 2007-07-09;116(4):385-91. 2007-07-09 [PMID: 17620507] (Human)
• Vik A, Brodin E, Sveinbjornsson B, Hansen JB Heparin induces mobilization of osteoprotegerin into the circulation. Thromb. Haemost., 2007-07-01;98(1):148-54. 2007-07-01 [PMID: 17598007] (Human)
• Naot D, Bava U, Matthews B, Callon KE, Gamble GD, Black M, Song S, Pitto RP, Cundy T, Cornish J, Reid IR Differential gene expression in cultured osteoblasts and bone marrow stromal cells from patients with Paget's disease of bone. J. Bone Miner. Res., 2007-02-01;22(2):298-309. 2007-02-01 [PMID: 17129176] (Human)
• Kawai T, Matsuyama T, Hosokawa Y, Makihira S, Seki M, Karimbux NY, Goncalves RB, Valverde P, Dibart S, Li YP, Miranda LA, Ernst CW, Izumi Y, Taubman MA B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease. Am. J. Pathol., 2006-09-01;169(3):987-98. 2006-09-01 [PMID: 16936272] (Human)
• Bersinger NA, von Roten S, Wunder DM, Raio L, Dreher E, Mueller MD PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis. Am. J. Obstet. Gynecol., 2006-04-25;195(1):103-8. 2006-04-25 [PMID: 16635455] (Human)
• de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts. J. Cell. Biochem., 2006-05-15;98(2):370-82. 2006-05-15 [PMID: 16440316] (Human)
• Mogi M, Otogoto J, Ota N, Togari A Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis. J. Dent. Res., 2004-02-01;83(2):166-9. 2004-02-01 [PMID: 14742657] (Human)
• Grimaud E, Soubigou L, Couillaud S, Coipeau P, Moreau A, Passuti N, Gouin F, Redini F, Heymann D Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis. Am. J. Pathol., 2003-11-01;163(5):2021-31. 2003-11-01 [PMID: 14578201] (Human)

Bioinformatics

• Gene Symbol: TNFRSF11B