Recombinant Human IL-7 Protein, CF

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human IL-7 Protein, CF Summary

• Details of Functionality: Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL). Yokota, T. et al. (1986) Proc. Natl. Acad. Sci. USA 83:5894. The ED 50 for this effect is 0.1-0.5 ng/mL.
• Source: E. coli-derived human IL-7 protein Asp26-His177, with an N-terminal Met
• Accession #: P13232
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: IL7
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 17 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 3 months, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Reconstitution Instructions: Reconstitute 5 μg vials at 50 μg/mL in sterile PBS. Reconstitute 10 μg or larger vials at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-7 Protein, CF

• IL7
• IL-7
• IL-7interleukin-7
• interleukin 7
• Lymphopoietin-1
• PBGF

Background

IL-7 (interleukin-7) is a 25 kDa cytokine of the hemopoietin family that plays important roles in lymphocyte differentiation, proliferation, and survival (1-4). Human IL-7 cDNA encodes 177 amino acids (aa) that include a 25 aa signal peptide (3). Human IL-7 shares approximately 60-63% aa sequence identity with mouse, rat, canine and feline IL-7, and 72-76% with equine, bovine, ovine, and porcine IL-7. Human and mouse IL-7 exhibit cross-species activity (2, 3). IL-7 is produced by a wide variety of cells in primary and secondary lymphoid tissues, including stromal epithelial cells of the thymus, bone marrow, and intestines (1, 2, 5). Circulating IL-7 is limiting in healthy animals, but increases during lymphopenia (1, 6). IL-7 signals through a complex of the IL-7 Receptor alpha subunit (IL-7 R alpha , also known as CD127) with the common gamma chain ( gamma c) (1). The gamma c is also a subunit of the receptors for IL-2, -4, -9, -15, and -21 (1). IL-7 R alpha is expressed on double negative (CD4-CD8-) and single positive (CD4+ or CD8+) naïve and memory T cells, but undergoes IL-7-mediated down-regulation and shedding during antigen-driven T cell proliferation, and is absent on regulatory T cells (1, 2, 6-11). IL-7 contributes to the maintenance of all naïve and memory T cells, mainly by promoting expression of the anti-apoptotic protein Bcl-2 (9-11). It is required for optimal T cell-dendritic cell interaction (6). IL-7 is expressed early in B cell development prior to the appearance of surface IgM (1, 5, 9). In mouse, IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development, while in humans, it is required for T cell but not for B cell development (4, 9, 12, 13). However, IL-7 functions in both mouse and human pro-B cells to suppress premature Ig light chain recombination during proliferative growth (14, 15). Like other common gamma-chain cytokines like IL-2 and IL-15, IL-7 and its receptor, IL-7R, have been used in a variety of immunotherapy applications, often in fluid tumors and in some instances of solid tumor models (16). Sometimes use of recombinant IL-7 is preferential as current studies and early clinical trials of cancer have found less severe toxicity or side effects upon treatment with IL-7 in comparison to IL-15 or IL-2 (16). In CAR-T cell therapies, enhanced expression and secretion of human IL-7 and CCL19 have enhanced the ability of T cells to expand and migrate in vitro (17). Engineered CAR T cells expressing IL-7 or a constitutively active IL-7R results in increased efficacy of CAR T anti-tumor effects (16, 18). IL-7 is also frequently used in combination with IL-15 as a supplement in cell culture of CAR T cells to support their expansion (19). Additionally, IL-7/IL-15 in the presence of cord blood-derived T cells helps to maintain their early differentiation state (20). Monoclonal antibodies against IL-7R or small molecule inhibitors against the IL-7R signaling pathway are commonly used in circumstances of autoimmune diseases to delay disease progression (16). Also due to its ability to stimulate both adaptive and innate immune cells, treatment with IL-7 has shown improved survival in patients with sepsis who are at risk of deadly secondary infections (21), providing evidence for IL-7 applications beyond cancer immunotherapy.

1. Sasson, S.C. et al. (2006) Curr. Drug Targets 7:1571.
2. Barata, J.T. et al. (2006) Exp. Hematol. 34:1133.
3. Goodwin, R.G. et al. (1990) Proc. Natl. Acad. Sci. USA 86:302.
4. Namen, A.E. et al. (1988) Nature 333:571.
5. Shalapour, S. et al. (2012) PLoS ONE 7: e31939.
6. Saini, M. et al. (2009) Blood 113:5793.
7. Park, J.H. et al. (2004) Immunity 21:289.
8. Vranjkovic, A. et al. (2007) Int. Immunol. 19:1329.
9. Sudo, T. et al. (1993) Proc. Natl. Acad. Sci. 90:9125.
10. Seddon, B. et al. (2003) Nat. Immunol. 4:680.
11. Schluns, K.S. et al. (2000) Nat. Immunol. 5:426.
12. Peschon, J.J. et al. (1994) J. Exp. Med. 180:1955.
13. Pribyl, J.A. and T.W. LeBien (1996) Proc. Natl. Acad. Sci. 93:10348.
14. Johnson, K. et al. (2012) J. Immunol. 188:6084.
15. Nodland, S.E. et al. (2011) Blood 118:2116.
16. Wang, C. et al. (2022) Int. J. Mol. Sci. 23(18).
17. Pang, N. et al. (2021) J Hematol Oncol. 14(118).
18. Li, L. et al. (2022) Scientific Reports. 12(12506).
19. Xu, Y. et al. (2014) Blood. 123(24): 3750-3759.
20. Marton, C. et al. (2022) Cancer Gene Ther. 29(7).
21. Winer, H. et al. (2022) Cytokine. 160(156049).

Publications for IL-7 (207-IL/CF)(151)

Publications using 207-IL/CF

• S Li, CS Wang, A Montel-Hag, HC Chen, S Lopez, O Zhou, K Dai, S Tsai, W Satyadi, C Botero, C Wong, D Casero, GM Crooks, CS Seet Strength of CAR signaling determines T�cell versus ILC differentiation from pluripotent stem cells Cell Reports, 2023-03-11;42(3):112241. 2023-03-11 [PMID: 36906850] (Bioassay, Human)
• T Tate, S Matsumoto, K Nemoto, M Leisegang, S Nagayama, K Obama, Y Nakamura, K Kiyotani Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3 Cancers, 2023-02-06;15(4):. 2023-02-06 [PMID: 36831375] (Bioassay, Human)
• D Proietto, B Dallan, E Gallerani, V Albanese, S Llewellyn-, DA Price, V Appay, S Pacifico, A Caputo, F Nicoli, R Gavioli Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2 Vaccines, 2023-01-11;11(1):. 2023-01-11 [PMID: 36679999] (Cell Culture, Human)
• Y Kitamura, YI Koma, K Tanigawa, S Tsukamoto, Y Azumi, S Miyako, S Urakami, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki Roles of IL-7R Induced by Interactions between Cancer Cells and Macrophages in the Progression of Esophageal Squamous Cell Carcinoma Cancers, 2023-01-06;15(2):. 2023-01-06 [PMID: 36672342] (Bioassay, Human)
• YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Bioassay, Human)
• R Jing, I Scarfo, MA Najia, E Lummertz d, A Han, M Sanborn, T Bingham, C Kubaczka, DK Jha, M Falchetti, TM Schlaeger, TE North, MV Maus, GQ Daley EZH1 repression generates mature iPSC-derived CAR T�cells with enhanced antitumor activity Cell Stem Cell, 2022-08-04;29(8):1181-1196.e6. 2022-08-04 [PMID: 35931029] (Bioassay, Human)
• P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 2022-03-11;14(6):. 2022-03-11 [PMID: 35326601] (Whole Cells, Human)
• GR Campbell, J Zhuang, G Zhang, I Landa, LJ Kubiatowic, D Dehaini, RH Fang, L Zhang, SA Spector CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells Theranostics, 2021-08-25;11(18):9009-9021. 2021-08-25 [PMID: 34522224] (Bioassay, Human)
• M Pino, S Pereira Ri, A Pagliuzza, K Ghneim, A Khan, E Ryan, JL Harper, CT King, S Welbourn, L Micci, S Aldrete, KA Delman, T Stuart, M Lowe, JM Brenchley, CA Derdeyn, K Easley, RP Sekaly, N Chomont, M Paiardini, VC Marconi Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART PloS Pathogens, 2021-08-27;17(8):e1009825. 2021-08-27 [PMID: 34449812] (Bioassay, Human)
• X Yang, X Zhao, Y Zhu, Y Shen, Y Wang, P Lu, Z Jiang, H Pan, J Yang, J Xun, L Zhao, J Wang, Z Liang, X Shen, Y Liang, Q Lin, H Liang, L Jin, D Zhang, J Liu, B Wang, S Jiang, J Xu, H Wu, H Lu, H Zhu FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat MBio, 2021-07-20;0(0):e0079521. 2021-07-20 [PMID: 34281390] (Bioassay, Human)
• AS Bear, T Blanchard, J Cesare, MJ Ford, LP Richman, C Xu, ML Baroja, S McCuaig, C Costeas, K Gabunia, J Scholler, AD Posey, MH O'Hara, A Smole, DJ Powell, BA Garcia, RH Vonderheid, GP Linette, BM Carreno Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting Nature Communications, 2021-07-16;12(1):4365. 2021-07-16 [PMID: 34272369] (Bioassay, Human)
• R Basar, N Uprety, E Ensley, M Daher, K Klein, F Martinez, F Aung, M Shanley, B Hu, E Gokdemir, AK Nunez Cort, M Mendt, F Reyes Silv, S Acharya, T Laskowski, L Muniz-Feli, PP Banerjee, Y Li, S Li, L Melo Garci, P Lin, H Shaim, SG Yates, D Marin, I Kaur, S Rao, D Mak, A Lin, Q Miao, J Dou, K Chen, RE Champlin, EJ Shpall, K Rezvani Generation of glucocorticoid-resistant SARS-CoV-2 T�cells for adoptive cell therapy Cell Reports, 2021-07-07;36(3):109432. 2021-07-07 [PMID: 34270918] (Bioassay, Human)
• J Boustani, ELM Joseph, E Martin, S Benhmida, B Lecoester, F Tochet, C Mirjolet, C Chevalier, D Thibouw, N Vulquin, S Servagi, X Sun, O Adotévi Cisplatin-based chemoradiation decreases telomerase-specific CD4 TH1 response but increases immune suppressive cells in peripheral blood BMC immunology, 2021-06-18;22(1):38. 2021-06-18 [PMID: 34144673] (Bioassay, Human)
• F Nicoli, S Pacifico, E Gallerani, E Marzola, V Albanese, V Finessi, S Llewellyn-, DA Price, V Appay, P Marconi, R Guerrini, A Caputo, R Gavioli Use of a Novel Peptide Welding Technology Platform for the Development of B- and T-Cell Epitope-Based Vaccines Vaccines, 2021-05-19;9(5):. 2021-05-19 [PMID: 34069535] (Bioassay, Human)
• S Jung, E Appleton, M Ali, GM Church, A Del Sol A computer-guided design tool to increase the efficiency of cellular conversions Nature Communications, 2021-03-12;12(1):1659. 2021-03-12 [PMID: 33712564] (Bioassay, Human)
• E Kidzeru, MA Gasper, D Shao, PT Edlefsen, N Lejarcegui, E Havyariman, K Urdahl, S Gantt, H Horton, H Jaspan, A Gervassi Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants Journal of leukocyte biology, 2021-01-21;0(0):. 2021-01-21 [PMID: 33477200] (Bioassay, Human)
• Roudko V, Bozkus C, Orfanelli T, McClain C, Carr C, O'Donnell T, Chakraborty L, Samstein R, Huang K, Blank S, Greenbaum B, Bhardwaj N Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors. Cell, 2020-11-30;183(6):1634-1649.e17. 2020-11-30 [PMID: 33259803] (Bioassay, Human)
• S Nagel, C Pommerenke, C Meyer, RAF MacLeod, HG Drexler Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia PLoS ONE, 2020-10-13;15(10):e0240120. 2020-10-13 [PMID: 33048949] (Cell Culture, Human)
• M Matsushita, S Saito, S Yokoe, D Ichikawa, Y Hattori Characteristics of a Novel Target Antigen Against Myeloma Cells for Immunotherapy Vaccines (Basel), 2020-10-02;8(4):. 2020-10-02 [PMID: 33023190] (Bioassay, Human)
• H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020-06-11;0(0):. 2020-06-11 [PMID: 32531207] (Bioassay, Human)
• F Hsiao, J Frouard, A Gramatica, G Xie, S Telwatte, GQ Lee, P Roychoudhu, R Schwarzer, X Luo, SA Yukl, S Lee, R Hoh, SG Deeks, RB Jones, M Cavrois, WC Greene, NR Roan Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection PLoS Pathog., 2020-04-30;16(4):e1008450. 2020-04-30 [PMID: 32353080] (Cell Culture, Human)
• A Mitra, MC Andrews, W Roh, MP De Macedo, CW Hudgens, F Carapeto, S Singh, A Reuben, F Wang, X Mao, X Song, K Wani, S Tippen, KS Ng, A Schalck, DA Sakellario, E Chen, SM Reddy, CN Spencer, D Wiesnoski, LD Little, C Gumbs, ZA Cooper, EM Burton, P Hwu, MA Davies, J Zhang, C Bernatchez, N Navin, P Sharma, JP Allison, JA Wargo, C Yee, MT Tetzlaff, WJ Hwu, AJ Lazar, PA Futreal Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma Nat Commun, 2020-04-15;11(1):1839. 2020-04-15 [PMID: 32296058] (Cell Culture, Human)
• DM Tufa, T Shank, AM Yingst, GD Trahan, S Shim, J Lake, R Woods, K Jones, MR Verneris Prolactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage Sci Rep, 2020-04-14;10(1):6335. 2020-04-14 [PMID: 32286456] (Bioassay, Human)
• J Wang, F Hasan, AC Frey, HS Li, J Park, K Pan, C Haymaker, C Bernatchez, DA Lee, SS Watowich, C Yee Histone deacetylase inhibitors and IL21 cooperate to reprogram human effector CD8+ T cells to memory T cells Cancer Immunol Res, 2020-03-25;0(0):. 2020-03-25 [PMID: 32213626] (Bioassay, Human)
• A Kunz, U Gern, A Schmitt, B Neuber, L Wang, A Hückelhove, B Michels, S Hofmann, C Müller-Tid, P Dreger, M Schmitt, ML Schubert Optimized Assessment of qPCR-Based Vector Copy Numbers as a Safety Parameter for GMP-Grade CAR T Cells and Monitoring of Frequency in Patients Mol Ther Methods Clin Dev, 2020-02-20;17(0):448-454. 2020-02-20 [PMID: 32201711] (Cell Culture, Human)
• H Bolouri, M Young, J Beilke, R Johnson, B Fox, L Huang, CC Santini, CM Hill, AVV Vries, PT Shannon, A Dervan, P Sivakumar, M Trotter, D Bassett, A Ratushny Integrative network modeling reveals mechanisms underlying T cell exhaustion Sci Rep, 2020-02-05;10(1):1915. 2020-02-05 [PMID: 32024856] (Bioassay, Human)
• N Borthwick, S Silva-Arri, A Llano, M Takiguchi, C Brander, T Hanke Novel Nested Peptide Epitopes Recognized by CD4+ T Cells Induced by HIV-1 Conserved-Region Vaccines Vaccines (Basel), 2020-01-16;8(1):. 2020-01-16 [PMID: 31963212] (Bioassay, Human)
• NL Truex, RL Holden, BY Wang, PG Chen, S Hanna, Z Hu, K Shetty, O Olive, D Neuberg, N Hacohen, DB Keskin, PA Ott, CJ Wu, BL Pentelute Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy Sci Rep, 2020-01-20;10(1):723. 2020-01-20 [PMID: 31959774] (Cell Culture, Human)
• C Seillet, K Luong, J Tellier, N Jacquelot, RD Shen, P Hickey, VC Wimmer, L Whitehead, K Rogers, GK Smyth, AL Garnham, ME Ritchie, GT Belz The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity Nat. Immunol., 2019-12-23;0(0):. 2019-12-23 [PMID: 31873294] (Cell Culture, Mouse)
• DN Nguyen, TL Roth, PJ Li, PA Chen, R Apathy, MR Mamedov, LT Vo, VR Tobin, D Goodman, E Shifrut, JA Bluestone, JM Puck, FC Szoka, A Marson Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency Nat. Biotechnol., 2019-12-09;0(0):. 2019-12-09 [PMID: 31819258] (Cell Culture, Human)
• A Guvenel, A Jozwik, S Ascough, SK Ung, S Paterson, M Kalyan, Z Gardener, E Bergstrom, S Kar, MS Habibi, A Paras, J Zhu, M Park, J Dhariwal, M Almond, EH Wong, A Sykes, J Del Rosari, MB Trujillo-T, P Mallia, J Sidney, B Peters, OM Kon, A Sette, SL Johnston, PJ Openshaw, C Chiu Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection J. Clin. Invest., 2020-01-02;0(0):. 2020-01-02 [PMID: 31815739] (Cell Culture, Human)
• JD Ventura, J Beloor, E Allen, T Zhang, KA Haugh, PD Uchil, C Ochsenbaue, C Kieffer, P Kumar, TJ Hope, W Mothes Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice PLoS Pathog., 2019-12-05;15(12):e1008161. 2019-12-05 [PMID: 31805155] (Cell Culture, Human)
• ZY Li, JJ Zhou, CL Luo, LM Zhang Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II?induced arthritis Mol Med Rep, 2019-09-26;20(5):4540-4550. 2019-09-26 [PMID: 31702035] (Cell Culture, Human)
• ER Wonderlich, K Subramania, B Cox, A Wiegand, C Lackman-Sm, MJ Bale, M Stone, R Hoh, MF Kearney, F Maldarelli, SG Deeks, MP Busch, RG Ptak, DA Kulpa Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals PLoS Pathog., 2019-10-14;15(10):e1008074. 2019-10-14 [PMID: 31609991] (Bioassay, Human)
• JH Bernink, Y Ohne, MBM Teunissen, J Wang, J Wu, L Krabbendam, C Guntermann, R Volckmann, J Koster, S van Tol, I Ramirez, Y Shrestha, MA de Rie, H Spits, X Romero Ros, AA Humbles c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies Nat. Immunol., 2019-07-01;0(0):. 2019-07-01 [PMID: 31263279] (Cell Culture, Human)
• HJ Yoo, Y Liu, L Wang, ML Schubert, JM Hoffmann, S Wang, B Neuber, A Hückelhove, U Gern, A Schmitt, C Müller-Tid, P Dreger, A Mokhir, M Schmitt, L Sellner Tumor-Specific Reactive Oxygen Species Accelerators Improve Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies Int J Mol Sci, 2019-05-18;20(10):. 2019-05-18 [PMID: 31109083] (CAR-T (Bioassay), Human)
• SR Ferdosi, R Ewaisha, F Moghadam, S Krishna, JG Park, MR Ebrahimkha, S Kiani, KS Anderson Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes Nat Commun, 2019-04-23;10(1):1842. 2019-04-23 [PMID: 31015529] (Bioassay, Human)
• HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis Nat Commun, 2019-02-12;10(1):709. 2019-02-12 [PMID: 30755603] (Bioassay, Human)
• K Kuranda, S Caillat-Zu, S You, R Mallone In�Vitro Expansion of Anti-viral T Cells from Cord Blood by Accelerated Co-cultured Dendritic Cells Mol Ther Methods Clin Dev, 2018-12-31;13(0):112-120. 2018-12-31 [PMID: 30740473] (Bioassay, Human)
• C Ammer-Herr, U Kulkarni, N Andreas, M Ungelenk, S Ravens, C Hübner, A Kather, I Kurth, M Bauer, T Kamradt Sepsis induces long-lasting impairments in CD4+ T-cell responses despite rapid numerical recovery of T-lymphocyte populations PLoS ONE, 2019-02-07;14(2):e0211716. 2019-02-07 [PMID: 30730978] (Mouse)
• S Whelan, E Ophir, MF Kotturi, O Levy, S Ganguly, L Leung, I Vaknin, S Kumar, L Dassa, K Hansen, D Bernados, B Murter, A Soni, JM Taube, AN Fader, TL Wang, IM Shih, M White, DM Pardoll, SC Liang PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function Cancer Immunol Res, 2019-01-18;0(0):. 2019-01-18 [PMID: 30659054] (Bioassay, Human)
• J Fu, J Zuber, M Martinez, B Shonts, A Obradovic, H Wang, SP Lau, A Xia, EE Waffarn, K Frangaj, TM Savage, MT Simpson, S Yang, XV Guo, M Miron, T Senda, K Rogers, A Rahman, SH Ho, Y Shen, A Griesemer, DL Farber, T Kato, M Sykes Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool Cell Stem Cell, 2018-11-29;0(0):. 2018-11-29 [PMID: 30503142] (Bioassay, Human)
• S Krishna, P Ulrich, E Wilson, F Parikh, P Narang, S Yang, AK Read, S Kim-Schulz, JG Park, M Posner, MA Wilson Say, A Sikora, KS Anderson Human papilloma virus specific immunogenicity and dysfunction of CD8+ T cells in head and neck cancer Cancer Res., 2018-08-28;0(0):. 2018-08-28 [PMID: 30154146] (Bioassay, Human)
• SR Kim, JM Lewis, BM Cyrenne, PF Monico, FN Mirza, KR Carlson, FM Foss, M Girardi BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition Oncotarget, 2018-06-26;9(49):29193-29207. 2018-06-26 [PMID: 30018745] (Bioassay, Human)
• X Zhao, S Sankaran, J Yap, CT Too, ZZ Ho, G Dolton, M Legut, EC Ren, AK Sewell, A Bertoletti, PA MacAry, J Brzostek, NRJ Gascoigne Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling Nat Commun, 2018-07-13;9(1):2716. 2018-07-13 [PMID: 30006605] (Bioassay, Human)
• LK Thampy, KE Remy, AH Walton, Z Hong, K Liu, R Liu, V Yi, CD Burnham, RS Hotchkiss Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration PLoS ONE, 2018-06-26;13(6):e0199497. 2018-06-26 [PMID: 29944697] (Bioassay, Human)
• DJHF Knapp, CA Hammond, T Hui, MTJ van Loenho, F Wang, N Aghaeepour, PH Miller, M Moksa, GM Rabu, PA Beer, D Pellacani, RK Humphries, C Hansen, M Hirst, CJ Eaves Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential Nat. Cell Biol., 2018-05-25;20(6):710-720. 2018-05-25 [PMID: 29802403] (Bioassay, Human)
• M Nakajima, M Kawaguchi, M Matsuyama, K Ota, J Fujita, S Matsukura, SK Huang, Y Morishima, Y Ishii, H Satoh, T Sakamoto, N Hizawa Transcription Elongation Factor P-TEFb Is Involved in IL-17F Signaling in Airway Smooth Muscle Cells Int. Arch. Allergy Immunol., 2018-04-12;0(0):. 2018-04-12 [PMID: 29649811] (Cell Culture, Human)
• D Chennamadh, NA Saavedra-A, LJ Carreño, MJ Guberman-P, P Arora, T Yongqing, HF Koay, DI Godfrey, S Keshipeddy, SK Richardson, S Sundararaj, JH Lo, X Wen, JA Gascón, W Yuan, J Rossjohn, J Le Nours, SA Porcelli, AR Howell Dual Modifications of ?-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity Cell Chem Biol, 2018-03-22;0(0):. 2018-03-22 [PMID: 29576533] (Bioassay, Human)
• S Zheng, E Papalexi, A Butler, W Stephenson, R Satija Molecular transitions in early progenitors during human cord blood hematopoiesis Mol. Syst. Biol., 2018-03-15;14(3):e8041. 2018-03-15 [PMID: 29545397] (Bioassay, Human)
• T Kato, T Matsuda, Y Ikeda, JH Park, M Leisegang, S Yoshimura, T Hikichi, M Harada, M Zewde, S Sato, K Hasegawa, K Kiyotani, Y Nakamura Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells Oncotarget, 2018-01-13;9(13):11009-11019. 2018-01-13 [PMID: 29541393] (Bioassay, Human)
• D Vignali, E Cantarelli, C Bordignon, A Canu, A Citro, A Annoni, L Piemonti, P Monti Detection and Characterization of CD8+ Autoreactive Memory Stem T Cells in Patients with Type 1 Diabetes Diabetes, 2018-03-05;0(0):. 2018-03-05 [PMID: 29506985] (Cell Culture, Human)
• N Terrazzini, P Mantegani, F Kern, C Fortis, A Mondino, S Caserta IL-7 unveils pathogen-specific T cells by enhancing antigen-recall responses J. Infect. Dis., 2018-05-25;0(0):. 2018-05-25 [PMID: 29506153] (Cell Culture, Human)
• U Kulkarni, C Herrmenau, SJ Win, M Bauer, T Kamradt IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells PLoS ONE, 2018-02-21;13(2):e0192304. 2018-02-21 [PMID: 29466409] (In Vivo, Mouse)
• C Thepmalee, A Panya, M Junking, T Chieochans, PT Yenchitsom Inhibition of IL-10 and TGF-? receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells Hum Vaccin Immunother, 2018-02-21;0(0):0. 2018-02-21 [PMID: 29420117] (Bioassay, Human)
• S Miyamoto, V Kochin, T Kanaseki, A Hongo, S Tokita, Y Kikuchi, A Takaya, Y Hirohashi, T Tsukahara, T Terui, K Ishitani, F Hata, I Takemasa, A Miyazaki, H Hiratsuka, N Sato, T Torigoe The antigen ASB4 on cancer stem cells serves as a target for CTL immunotherapy of colorectal cancer Cancer Immunol Res, 2018-01-25;0(0):. 2018-01-25 [PMID: 29371260] (Bioassay, Human)
• M Bardet, A Unterreine, C Malinverni, F Lafossas, C Vedrine, D Boesch, Y Kolb, D Kaiser, A Glück, MA Schneider, A Katopodis, M Renatus, O Simic, A Schlapbach, J Quancard, CH Régnier, G Bold, C Pissot-Sol, JM Carballido, J Kovarik, T Calzascia, F Bornancin The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition Immunol. Cell Biol., 2017-12-21;96(1):81-99. 2017-12-21 [PMID: 29359407] (Bioassay, Human)
• A Camelo, G Rosignoli, Y Ohne, RA Stewart, C Overed-Say, MA Sleeman, RD May IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells Blood Adv, 2017-03-30;1(10):577-589. 2017-03-30 [PMID: 29296700] (Human)
• Y Hijikata, T Okazaki, Y Tanaka, M Murahashi, Y Yamada, K Yamada, A Takahashi, H Inoue, J Kishimoto, Y Nakanishi, Y Oda, Y Nakamura, K Tani A phase I clinical trial of RNF43 peptide-related immune cell therapy combined with low-dose cyclophosphamide in patients with advanced solid tumors PLoS ONE, 2018-01-02;13(1):e0187878. 2018-01-02 [PMID: 29293510] (Bioassay, Human)
• C Gavegnano, JH Brehm, FP Dupuy, A Talla, SP Ribeiro, DA Kulpa, C Cameron, S Santos, SJ Hurwitz, VC Marconi, JP Routy, L Sabbagh, RF Schinazi, RP Sékaly Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors PLoS Pathog., 2017-12-21;13(12):e1006740. 2017-12-21 [PMID: 29267399] (Bioassay, Human)
• M Yoshida, Y Ishioka, T Ozawa, H Okuyama, M Iguchi, T Ota, T Ito, M Nagira, A Morita, H Tanaka, H Naito, H Kidoya, N Takakura Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency Sci Rep, 2017-09-11;7(1):11137. 2017-09-11 [PMID: 28894200] (Bioassay, Human)
• CA Ramos, B Ballard, H Zhang, O Dakhova, AP Gee, Z Mei, M Bilgi, MF Wu, H Liu, B Grilley, CM Bollard, BH Chang, CM Rooney, MK Brenner, HE Heslop, G Dotti, B Savoldo Clinical and immunological responses after CD30-specific chimeric antigen receptor-redirected lymphocytes J. Clin. Invest., 2017-08-14;0(0):. 2017-08-14 [PMID: 28805662] (Bioassay, Human)
• F Venet, J Demaret, BJ Blaise, C Rouget, T Girardot, E Idealisoa, T Rimmelé, F Mallet, A Lepape, J Textoris, G Monneret IL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation J. Immunol., 2017-07-19;0(0):. 2017-07-19 [PMID: 28724580] (Bioassay, Human)
• Heczey A, Louis C, Savoldo B, Dakhova O, Durett A, Grilley B, Liu H, Wu M, Mei Z, Gee A, Mehta B, Zhang H, Mahmood N, Tashiro H, Heslop H, Dotti G, Rooney C, Brenner M CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma. Mol Ther, 2017-06-09;25(9):2214-2224. 2017-06-09 [PMID: 28602436] (CAR-T (Bioassay), Human)
• JA Poposki, AI Klingler, BK Tan, P Soroosh, H Banie, G Lewis, KE Hulse, WW Stevens, AT Peters, LC Grammer, RP Schleimer, KC Welch, SS Smith, DB Conley, JR Raviv, JG Karras, O Akbari, RC Kern, A Kato Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps Immun Inflamm Dis, 2017-04-19;0(0):. 2017-04-19 [PMID: 28474861] (Bioassay, Human)
• J Ding, ML Fishel, AM Reed, E McAdams, M Czader, AA Cardoso, MR Kelley Ref-1/APE1 as Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia Mol. Cancer Ther., 2017-04-26;0(0):. 2017-04-26 [PMID: 28446640] (Bioassay, Human)
• Y Van Caeneg, S De Munter, P Tieppo, G Goetgeluk, K Weening, G Verstichel, S Bonte, T Taghon, G Leclercq, T Kerre, R Debets, D Vermijlen, H Abken, B Vandekerck Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities Oncoimmunology, 2017-01-19;6(3):e1283460. 2017-01-19 [PMID: 28405508] (Bioassay, Human)
• S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1 Nat. Methods, 2017-04-10;14(5):531-538. 2017-04-10 [PMID: 28394335] (Bioassay, Human)
• Z Zhang, Q He, Y Tao, J Guo, F Xu, LY Wu, YS Zhao, D Wu, LY Zhou, JY Su, LX Song, C Xiao, X Li, CK Chang Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes Am J Transl Res, 2017-02-15;9(2):454-465. 2017-02-15 [PMID: 28337274] (Bioassay, Human)
• T Koya, R Yanagisawa, Y Higuchi, K Sano, S Shimodaira Interferon-?-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas Ligand Pathway-mediated Killer Activity Sci Rep, 2017-02-13;7(0):42145. 2017-02-13 [PMID: 28191816] (Bioassay, Human)
• M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells Clin. Cancer Res, 2017-02-09;0(0):. 2017-02-09 [PMID: 28183713] (Bioassay, Human)
• L Turtle, F Tatullo, T Bali, V Ravi, M Soni, S Chan, S Chib, MM Venkataswa, P Fadnis, M Ya‹ch, S Fernandez, P Klenerman, V Satchidana, T Solomon Cellular Immune Responses to Live Attenuated Japanese Encephalitis (JE) Vaccine SA14-14-2 in Adults in a JE/Dengue Co-Endemic Area PLoS Negl Trop Dis, 2017-01-30;11(1):e0005263. 2017-01-30 [PMID: 28135273] (Bioassay, Human)
• Anja Kerstein Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis J. Autoimmun, 2016-12-28;0(0):. 2016-12-28 [PMID: 28040323] (Bioassay, Human)
• Human Cytomegalovirus miR-UL148D Facilitates Latent Viral Infection by Targeting Host Cell Immediate Early Response Gene 5 PLoS Pathog., 2016-11-08;12(11):e1006007. 2016-11-08 [PMID: 27824944] (Bioassay, Human)
• Interleukin-7 Plasma Levels in Human Differentiate Anorexia Nervosa, Constitutional Thinness and Healthy Obesity PLoS ONE, 2016-09-09;11(9):e0161890. 2016-09-09 [PMID: 27611669] (ELISA (Standard), Human)
• Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance Oncoimmunology, 2016-06-08;5(6):e1165376. 2016-06-08 [PMID: 27471640] (Bioassay, Human)
• Efficient regeneration of Human V?24(+) invariant NKT cells and their anti-tumor activity in vivo Stem Cells, 2016-08-01;0(0):. 2016-08-01 [PMID: 27422351] (Bioassay, Human)
• CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia Mol Ther, 2016-06-06;0(0):. 2016-06-06 [PMID: 27401038] (CAR-T (Bioassay), Human)
• Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects Stem Cell Reports, 2016-07-07;0(0):. 2016-07-07 [PMID: 27396937] (Bioassay, Human)
• Vesna Pulko Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses Nat Immunol, 2016-06-06;0(0):. 2016-06-06 [PMID: 27270402] (Bioassay, Human)
• I Menkova-Ga, H Hocini, E Foucat, P Tisserand, L Bourdery, C Delaugerre, C Benne, Y Lévy, JD Lelièvre P2X7 Receptor Inhibition Improves CD34 T-Cell Differentiation in HIV-Infected Immunological Nonresponders on c-ART PLoS Pathog, 2016-04-15;12(4):e1005571. 2016-04-15 [PMID: 27082982] (Bioassay, Human)
• RB Jones, S Mueller, R O'Connor, K Rimpel, DD Sloan, D Karel, HC Wong, EK Jeng, AS Thomas, JB Whitney, SY Lim, C Kovacs, E Benko, S Karandish, SH Huang, MJ Buzon, M Lichterfel, A Irrinki, JP Murry, A Tsai, H Yu, R Geleziunas, A Trocha, MA Ostrowski, Irvi A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes PLoS Pathog, 2016-04-15;12(4):e1005545. 2016-04-15 [PMID: 27082643] (Bioassay, Human)
• J Dias, MJ Sobkowiak, JK Sandberg, E Leeansyah Human MAIT-cell responses to Escherichia coli: activation, cytokine production, proliferation, and cytotoxicity J Leukoc Biol, 2016-03-31;0(0):. 2016-03-31 [PMID: 27034405] (Bioassay, Human)
• Chai S, Yap Y, Foo Y, Yap L, Ponniah S, Teo S, Cheong S, Patel V, Lim K Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma. PLoS ONE, 2015-11-04;10(11):e0130464. 2015-11-04 [PMID: 26536470] (Bioassay, Human)
• El Azreq M, Arseneault C, Boisvert M, Page N, Allaeys I, Poubelle P, Tessier P, Aoudjit F Cooperation between IL-7 Receptor and Integrin alpha2beta1 (CD49b) Drives Th17-Mediated Bone Loss. J Immunol, 2015-09-25;195(9):4198-209. 2015-09-25 [PMID: 26408663] (Bioassay, Human)
• Leeansyah E, Svard J, Dias J, Buggert M, Nystrom J, Quigley M, Moll M, Sonnerborg A, Nowak P, Sandberg J Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection. PLoS Pathog, 2015-08-21;11(8):e1005072. 2015-08-21 [PMID: 26295709] (Bioassay, Human)
• Thomas S, Klobuch S, Podlech J, Plachter B, Hoffmann P, Renzaho A, Theobald M, Reddehase M, Herr W, Lemmermann N Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice. PLoS Pathog, 2015-07-16;11(7):e1005049. 2015-07-16 [PMID: 26181057] (Bioassay, Human)
• Huang X, Park H, Greene J, Pao J, Mulvey E, Zhou S, Albert C, Moy F, Sachdev D, Yee D, Rader C, Hamby C, Loeb D, Cairo M, Zhou X IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas. PLoS ONE, 2015-07-14;10(7):e0133152. 2015-07-14 [PMID: 26173023] (Bioassay, Human)
• Fujiwara H, Ochi T, Ochi F, Miyazaki Y, Asai H, Narita M, Okamoto S, Mineno J, Kuzushima K, Shiku H, Yasukawa M Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer. Leukemia, 2015-06-24;29(12):2393-401. 2015-06-24 [PMID: 26104661] (Bioassay, Human)
• Yousef S, Heise J, Lajmi N, Bartels K, Kroger N, Luetkens T, Atanackovic D Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma. J Transl Med, 2015-06-20;13(0):197. 2015-06-20 [PMID: 26088750] (Bioassay, Human)
• Artyomov M, Munk A, Gorvel L, Korenfeld D, Cella M, Tung T, Klechevsky E Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells. J Exp Med, 2015-04-27;212(5):743-57. 2015-04-27 [PMID: 25918340] (Bioassay, Human)
• Li Y, Yan B, Wang H, Li H, Li Q, Zhao D, Chen Y, Zhang Y, Li W, Zhang J, Wang S, Shen J, Li Y, Guindi E, Zhao Y Hair regrowth in alopecia areata patients following Stem Cell Educator therapy. BMC Med, 2015-04-20;13(0):87. 2015-04-20 [PMID: 25896390] (Bioassay, Human)
• Wyndham-Thomas C, Dirix V, Schepers K, Martin C, Hildebrand M, Goffard J, Domont F, Libin M, Loyens M, Locht C, Van Vooren J, Mascart F Contribution of a heparin-binding haemagglutinin interferon-gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV-infected patients: comparison with the tuberculin skin test and the QuantiFERON-TB Gold In-tube. BMC Infect Dis, 2015-02-14;15(0):59. 2015-02-14 [PMID: 25886172] (Bioassay, Human)
• Li Z, Younger K, Gartenhaus R, Joseph A, Hu F, Baer M, Brown P, Davila E Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies. J Clin Invest, 2015-02-02;125(3):1081-97. 2015-02-02 [PMID: 25642772] (Bioassay, Human)
• Arber C, Feng X, Abhyankar H, Romero E, Wu M, Heslop H, Barth P, Dotti G, Savoldo B Survivin-specific T cell receptor targets tumor but not T cells. J Clin Invest, 2014-11-21;125(1):157-68. 2014-11-21 [PMID: 25415440] (Bioassay, Human)
• Lam , Sharon, Sung , Julia, Cruz , Conrad, Castillo-Caro , Paul, Ngo , Minhtran, Garrido , Carolina, Kuruc , Joann, Archin , Nancie, Rooney , Cliona, Margolis , David, Bollard , Catherin Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy. Mol Ther, 2014-11-04;23(2):387-95. 2014-11-04 [PMID: 25366030] (Bioassay, Human)
• Gervassi , Ana, Lejarcegui , Nicholas, Dross , Sandra, Jacobson , Amanda, Itaya , Grace, Kidzeru , Elvis, Gantt , Soren, Jaspan , Heather, Horton , Helen Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses. PLoS ONE, 2014-09-23;9(9):e107816. 2014-09-23 [PMID: 25248150] (Bioassay, Human)
• Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion. PLoS ONE, 2014-09-03;9(9):e106673. 2014-09-03 [PMID: 25184791] (Bioassay, Human)
• Sehgal K, Ragheb R, Fahmy T, Dhodapkar M, Dhodapkar K Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk. J Immunol, 2014-07-30;193(5):2297-305. 2014-07-30 [PMID: 25080481] (Bioassay, Human)
• Yamahira A, Narita M, Iwabuchi M, Uchiyama T, Iwaya S, Ohiwa R, Nishizawa Y, Suzuki T, Yokoyama Y, Hashimoto S, Takizawa J, Sone H, Takahashi M Activation of the leukemia plasmacytoid dendritic cell line PMDC05 by Toho-1, a novel IDO inhibitor. Anticancer Res, 2014-08-01;34(8):4021-8. 2014-08-01 [PMID: 25075025] (Bioassay, Human)
• Cha L, de Jong E, French M, Fernandez S IFN-alpha exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection. J Immunol, 2014-07-25;193(5):2178-86. 2014-07-25 [PMID: 25063872] (Bioassay, Human)
• Dupont G, Demaret J, Venet F, Malergue F, Malcus C, Poitevin-Later F, Morel J, Monneret G Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4+FOXP3- cells versus regulatory T cells: a whole blood perspective. Cytokine, 2014-06-16;69(1):146-9. 2014-06-16 [PMID: 24947990] (Bioassay, Human)
• Lepore M, de Lalla C, Gundimeda S, Gsellinger H, Consonni M, Garavaglia C, Sansano S, Piccolo F, Scelfo A, Haussinger D, Montagna D, Locatelli F, Bonini C, Bondanza A, Forcina A, Li Z, Ni G, Ciceri F, Jeno P, Xia C, Mori L, Dellabona P, Casorati G, De Libero G A novel self-lipid antigen targets human T cells against CD1c(+) leukemias. J Exp Med, 2014-06-16;211(7):1363-77. 2014-06-16 [PMID: 24935257] (Bioassay, Human)
• Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J Allergy Clin Immunol, 2014-06-06;134(2):373-81. 2014-06-06 [PMID: 24910175] (Bioassay, Human)
• Khoo M, Carlin S, Lutherborrow M, Jayaswal V, Ma D, Moore J Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells. Aging Cell, 2014-05-30;13(4):744-54. 2014-05-30 [PMID: 24889652] (Bioassay, Human)
• Yang C, French A, Goh P, Pagnamenta A, Mettananda S, Taylor J, Knight S, Nathwani A, Roberts D, Watt S, Carpenter L Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co-express gamma and beta globins. Br J Haematol, 2014-05-16;166(3):435-48. 2014-05-16 [PMID: 24837254] (Bioassay, Human)
• Duluc D, Joo H, Ni L, Yin W, Upchurch K, Li D, Xue Y, Klucar P, Zurawski S, Zurawski G, Oh S Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1. J Immunol, 2014-05-16;192(12):5776-88. 2014-05-16 [PMID: 24835401] (Bioassay, Human)
• Chung B, Montel-Hagen A, Ge S, Blumberg G, Kim K, Klein S, Zhu Y, Parekh C, Balamurugan A, Yang O, Crooks G Engineering the human thymic microenvironment to support thymopoiesis in vivo. Stem Cells, 2014-09-01;32(9):2386-96. 2014-09-01 [PMID: 24801626] (Bioassay, Human)
• Williams M, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman K, McAndrew R, Thomas A, Spence A, Gibson B, Graham G, Halsey C Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 2014-04-03;123(20):3116-27. 2014-04-03 [PMID: 24700781] (Bioassay, Human)
• Picco G, Beatson R, Taylor-Papadimitriou J, Burchell J Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas. Eur J Immunol, 2014-04-17;44(7):1947-55. 2014-04-17 [PMID: 24648154] (Bioassay, Human)
• Harris K, Ramachandran G, Basu S, Rollins S, Mann D, Cross A The IL-23/Th17 axis is involved in the adaptive immune response to Bacillus anthracis in humans. Eur J Immunol, 2014-01-02;44(3):752-62. 2014-01-02 [PMID: 24643777] (Bioassay, Human)
• Banu , Nasirah, Chia , Adeline, Ho , Zi Zong, Garcia , Alfonso, Paravasivam , Komathi, Grotenbreg , Gijsbert, Bertoletti , Antonio, Gehring , Adam J Building and optimizing a virus-specific T cell receptor library for targeted immunotherapy in viral infections. Sci Rep, 2014-02-25;4(0):4166. 2014-02-25 [PMID: 24566718] (Bioassay, Human)
• Reynolds , C, Roderick , J E, LaBelle , J L, Bird , G, Mathieu , R, Bodaar , K, Colon , D, Pyati , U, Stevenson , K E, Qi , J, Harris , M, Silverman , L B, Sallan , S E, Bradner , J E, Neuberg , D S, Look , A T, Walensky , L D, Kelliher , M A, Gutierrez , A Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia, 2014-02-20;28(9):1819-27. 2014-02-20 [PMID: 24552990] (Bioassay, Human)
• Demotte N, Bigirimana R, Wieers G, Stroobant V, Squifflet J, Carrasco J, Thielemans K, Baurain J, Van Der Smissen P, Courtoy P, van der Bruggen P A short treatment with galactomannan GM-CT-01 corrects the functions of freshly isolated human tumor-infiltrating lymphocytes. Clin Cancer Res, 2014-02-13;20(7):1823-33. 2014-02-13 [PMID: 24526733] (Bioassay, Human)
• Du M, Guo P, Piao H, Wang S, Sun C, Jin L, Tao Y, Li Y, Zhang D, Zhu R, Fu Q, Li D Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells. J Immunol, 2014-01-22;192(4):1502-11. 2014-01-22 [PMID: 24453244] (Bioassay, Human)
• Bastidas S, Graw F, Smith M, Kuster H, Gunthard H, Oxenius A CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals. J Immunol, 2014-01-20;192(4):1732-44. 2014-01-20 [PMID: 24446519] (Bioassay, Human)
• Uttenthal B, Martinez-Davila I, Ivey A, Craddock C, Chen F, Virchis A, Kottaridis P, Grimwade D, Khwaja A, Stauss H, Morris E Wilms&#039; Tumour 1 (WT1) peptide vaccination in patients with acute myeloid leukaemia induces short-lived WT1-specific immune responses. Br J Haematol, 2013-11-16;164(3):366-75. 2013-11-16 [PMID: 24422723] (Bioassay, Human)
• Carlson L, De Geer A, Sveinbjornsson B, Orrego A, Martinsson T, Kogner P, Levitskaya J The microenvironment of human neuroblastoma supports the activation of tumor-associated T lymphocytes. Oncoimmunology, 2013-03-01;2(3):e23618. 2013-03-01 [PMID: 23802089] (Bioassay, Human)
• Di J, Massuger L, Duiveman-de Boer T, Zusterzeel P, Figdor C, Torensma R Functional OCT4-specific CD4 and CD8 T cells in healthy controls and ovarian cancer patients. Oncoimmunology, 2013-04-01;2(5):e24271. 2013-04-01 [PMID: 23762805] (Bioassay, Human)
• Chen Z, Kim S, Chamberlain N, Pickens S, Volin M, Volkov S, Arami S, Christman J, Prabhakar B, Swedler W, Mehta A, Sweiss N, Shahrara S The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis. J Immunol, 2013-04-19;190(10):5256-66. 2013-04-19 [PMID: 23606539] (Bioassay, Human)
• Tang , Xin-Zi, Jo , Juandy, Tan , Anthony, Sandalova , Elena, Chia , Adeline, Tan , Kai Chah, Lee , Kang Hoe, Gehring , Adam J, De Libero , Gennaro, Bertoletti , Antonio IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol, 2013-02-27;190(7):3142-52. 2013-02-27 [PMID: 23447689] (Bioassay, Human)
• Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients. Clin Cancer Res, 2013-02-26;19(7):1858-72. 2013-02-26 [PMID: 23444227] (Bioassay, Human)
• Hirayama M, Nishikawa H, Nagata Y, Tsuji T, Kato T, Kageyama S, Ueda S, Sugiyama D, Hori S, Sakaguchi S, Ritter G, Old L, Gnjatic S, Shiku H Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes. Eur J Immunol, 2013-02-26;43(4):989-1000. 2013-02-26 [PMID: 23436617] (Bioassay, Human)
• Dong J, Chang H, Ivascu C, Qian Y, Rezai S, Okhrimenko A, Cosmi L, Maggi L, Eckhardt F, Wu P, Sieper J, Alexander T, Annunziato F, Gossen M, Li J, Radbruch A, Thiel A Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-gamma memory in human CD4(+) T lymphocytes. Eur J Immunol, 2013-03-01;43(3):793-804. 2013-03-01 [PMID: 23255246] (Bioassay, Human)
• Alonzo , Francis, Kozhaya , Lina, Rawlings , Stephen, Reyes-Robles , Tamara, DuMont , Ashley L, Myszka , David G, Landau , Nathanie, Unutmaz , Derya, Torres , Victor J CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature, 2012-12-12;493(7430):51-5. 2012-12-12 [PMID: 23235831] (Cell Culture, Human)
• Brusic , Ana, Hainz , Ursula, Wadleigh , Martha, Neuberg , Donna, Su , Mei, Canning , Christin, Deangelo , Daniel J, Stone , Richard, Lee , Jeng-Shi, Mulligan , Richard, Ritz , Jerome, Dranoff , Glenn, Sasada , Tetsuro, Wu , Catherin Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients. Oncoimmunology, 2012-10-01;1(7):1095-1103. 2012-10-01 [PMID: 23170257] (Bioassay, Human)
• Venet F, Foray A, Villars-Mechin A, Malcus C, Poitevin-Later F, Lepape A, Monneret G IL-7 Restores Lymphocyte Functions in Septic Patients. J Immunol, 2012-10-10;189(10):5073-81. 2012-10-10 [PMID: 23053510] (Bioassay, Human)
• Inderberg-Suso E, Trachsel S, Lislerud K, Rasmussen A, Gaudernack G Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001. Oncoimmunology, 2012-08-01;1(5):670-686. 2012-08-01 [PMID: 22934259] (Bioassay, Human)
• Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA Antigen-independent induction of Tim-3 expression on human T cells by the common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway. J. Immunol., 2012-03-14;188(8):3745-56. 2012-03-14 [PMID: 22422881] (Bioassay, Human)
• Nielsen N, Odum N, Urso B, Lanier LL, Spee P Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A. PLoS ONE, 2012-02-22;7(2):e31959. 2012-02-22 [PMID: 22384114] (Bioassay, Human)
• Donnelly , O G, Errington-Mais , F, Steele , L, Hadac , E, Jennings , V, Scott , K, Peach , H, Phillips , R M, Bond , J, Pandha , H, Harrington , K, Vile , R, Russell , S, Selby , P, Melcher , A A Measles virus causes immunogenic cell death in human melanoma. Gene Ther, 2011-12-15;20(1):7-15. 2011-12-15 [PMID: 22170342] (Bioassay, Human)
• Ichii , Michiko, Frank , Mark Bar, Iozzo , Renato V, Kincade , Paul W The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood, 2011-11-23;119(7):1683-92. 2011-11-23 [PMID: 22117039] (Bioassay, Human)
• Milpied P, Massot B, Renand A, Diem S, Herbelin A, Leite-de-Moraes M, Rubio MT, Hermine O IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression. Blood, 2011-06-08;118(11):2993-3002. 2011-06-08 [PMID: 21653940] (Bioassay, Mouse)
• Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response. J. Immunol., 2010-10-27;185(11):6646-63. 2010-10-27 [PMID: 20980630] (Bioassay, Human)
• Unsinger J, McGlynn M, Kasten KR, Hoekzema AS, Watanabe E, Muenzer JT, McDonough JS, Tschoep J, Ferguson TA, McDunn JE, Morre M, Hildeman DA, Caldwell CC, Hotchkiss RS IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J. Immunol., 2010-03-03;184(7):3768-79. 2010-03-03 [PMID: 20200277] (In Vivo, Mouse)
• Erlendsson LS, Muench MO, Hellman U, Hrafnkelsdottir SM, Jonsson A, Balmer Y, Mantyla E, Orvar BL Barley as a green factory for the production of functional Flt3 ligand. Biotechnol J, 2010-02-01;5(2):163-71. 2010-02-01 [PMID: 19844912] (Bioassay, Human)
• Lotem M, Machlenkin A, Hamburger T, Nissan A, Kadouri L, Frankenburg S, Gimmon Z, Elias O, David IB, Kuznetz A, Shiloni E, Peretz T Autologous melanoma vaccine induces antitumor and self-reactive immune responses that affect patient survival and depend on MHC class II expression on vaccine cells. Clin. Cancer Res., 2009-07-14;15(15):4968-77. 2009-07-14 [PMID: 19602547] (Bioassay, Human)
• Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin&#039;s lymphoma. Int. J. Cancer, 2009-09-01;125(5):1092-101. 2009-09-01 [PMID: 19391137] (Bioassay, Human)
• Yammani RR, Long D, Loeser RF Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum., 2009-03-01;60(3):792-800. 2009-03-01 [PMID: 19248116] (Bioassay, Human)
• Spiegl N, Didichenko S, McCaffery P, Langen H, Dahinden CA Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid. Blood, 2008-05-21;112(9):3762-71. 2008-05-21 [PMID: 18495959] (Bioassay, Human)
• Gendron S, Boisvert M, Chetoui N, Aoudjit F alpha1beta1 integrin and interleukin-7 receptor up-regulate the expression of RANKL in human T cells and enhance their osteoclastogenic function. Immunology, 2008-05-13;125(0):359. 2008-05-13 [PMID: 18479350] (Bioassay, Human)
• Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62. 2008-03-01 [PMID: 18327985] (ELISA (Standard))
• McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. Exp. Hematol., 2008-03-04;36(5):598-608. 2008-03-04 [PMID: 18295962] (Bioassay, Human)
• Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem., 2007-09-21;53(11):1990-5. 2007-09-21 [PMID: 17890441] (ELISA (Standard))
• Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (ELISA (Standard))
• Kersten C, Dosen G, Myklebust JH, Sivertsen EA, Hystad ME, Smeland EB, Rian E BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3. Exp. Hematol., 2006-01-01;34(1):72-81. 2006-01-01 [PMID: 16413393] (Bioassay, Human)
• Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism. J. Immunol., 2005-02-15;174(4):2376-86. 2005-02-15 [PMID: 15699174] (Bioassay, Human)
• Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 2004-09-01;173(5):3482-91. 2004-09-01 [PMID: 15322213] (Bioassay, Human)
• Locher CP, Witt SA, Ashlock BM, Polacino P, Hu SL, Shiboski S, Schmidt AM, Agy MB, Anderson DM, Staprans SI, zur Megede J, Levy JA Human immunodeficiency virus type 2 DNA vaccine provides partial protection from acute baboon infection. Vaccine, 2004-06-02;22(17):2261-72. 2004-06-02 [PMID: 15149785] (Bioassay, Primate - Papio cynocephalus (Yellow Baboon))
• O&amp;apos;Connor DH Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence? J. Virol., 2002-11-01;76(22):11623-36. 2002-11-01 [PMID: 12388723] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))
• Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D, Marme F, Cherel Y, Salvetti A, Hurtrel B, Heard JM, Riviere Y, Moullier P Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus. J. Virol., 2002-11-01;76(22):11605-11. 2002-11-01 [PMID: 12388721] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))

Bioinformatics

• Gene Symbol: IL7
• Uniprot:
  • P13232()