Immunogen | Human STAT5b synthetic peptide aa 777-787 |
Specificity | Detects human and mouse STAT5b. |
Source | N/A |
Isotype | IgG |
Clonality | Polyclonal |
Host | Rabbit |
Gene | STAT5B |
Purity Statement | Antigen Affinity-purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Application Notes | In Simple Western only 10-15 uL of the recommended dilution is used per data point. |
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Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative | No Preservative |
Concentration | LYOPH |
Reconstitution Instructions | Reconstitute at 0.2 mg/mL in sterile PBS. |
Signal transduction and activator of transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL22, IL6, IFN-α). STAT5 has two isoforms (A and B) that share 93% amino acid identity and bind the DNA consensus site TTCN3GAA. STAT5 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, translocates to the nucleus and activates transcription of specific genes. STAT5 is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival.
Images | Ratings | Applications | Species | Date | Details | ||||||
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reviewed by:
Verified Customer |
WB | Human | 01/05/2015 |
Summary
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Secondary Antibodies |
Isotype Controls |
Diseases for STAT5b Antibody (AF1584)Discover more about diseases related to STAT5b Antibody (AF1584).
| Pathways for STAT5b Antibody (AF1584)View related products by pathway.
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PTMs for STAT5b Antibody (AF1584)Learn more about PTMs related to STAT5b Antibody (AF1584).
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Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an... Read full blog post. |
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Gene Symbol | STAT5B |