Recombinant Human Follistatin 288 (FS-288) Protein


There are currently no images for Follistatin (5836-FS).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

Order Details

View Available Formulations
Catalog# & Formulation Size Price

Recombinant Human Follistatin 288 (FS-288) Protein Summary

Details of Functionality
Measured by its ability to neutralize Activin-mediated erythroid differentiation of K562 human chronic myelogenous leukemia cells.

The ED50 for this effect is 0.05‑0.25 μg/mL in the presence of 7.5 ng/mL of rhActivin A.

Spodoptera frugiperda, Sf 21 (baculovirus)-derived human Follistatin protein
Gly30-Asn317, with an N-terminal Met
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.


Theoretical MW
31.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
35-40 kDa, reducing conditions
Read Publications using
5836-FS in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Follistatin 288 (FS-288) Protein

  • follistatin isoform FST317
  • Follistatin
  • FS
  • FSActivin-binding protein
  • FST


Follistatin 288 (FST288) is one of three forms of follistatin, a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human follistatin 288 cDNA encodes a 317 amino acid (aa) protein with a 29 aa signal sequence, and a 288 aa mature region. Human FST288 shares 97 - 99% aa identity with corresponding regions of mouse, rat, equine, ovine, porcine and bovine FST. All forms of follistatin, including FST288, FST303 and FST315, contain an N-terminal atypical TGF binding domain and three follistatin domains (FS1 - 3) that contain EGF-like and kazal-like motifs. A highly acidic C-terminal tail is missing in the splice variant FST288, partially present in the proteolytically produced FST303, and full-length in the most abundant form, FST315 (5, 8, 9). FSTs inhibit activins by surrounding activin dimers. FST288 shows the highest affinity for activins due to its extended configuration, while FST315 is in a folded form (2, 8). Expression of the isoforms is restricted such that FST288, which has higher affinity for heparin-sulfated proteoglycans when unbound, is present in tissues while FST315 is the sole form in plasma and ovarian follicular fluid (5, 8, 9). In addition to activin, follistatins regulate the bioavailability of other members of the TGF-beta superfamily, such as BMP6, BMP7 and myostatin (5). Follistatins also regulate hematopoietic stem cell adhesion to fibronectin via FS2, and bind angiogenin via FS2 and FS3 (6, 7). Genetic deletion of follistatin in mice, or expression of only the FST288 form, is perinatally lethal due to defects of lung, skin and musculoskeletal system (10). Mice that express only the FST315 isoform survive, but exhibit defects in vascularization and female fertility (10).

  1. Shimasaki, S. et al. (1988) Proc. Natl. Acad. Sci. USA 85:4218. 
  2. Thompson, T.B. et al. (2005) Dev. Cell 9:535. 
  3. Sidis, Y. et al. (2005) Endocrinology 146:130. 
  4. Keutmann, H.T. et al. (2004) Mol. Endocrinol. 18:228. 
  5. Sidis, Y. et al. (2006) Endocrinology 147:3586. 
  6. Maguer-Satta, V. et al. (2006) Exp. Cell Res. 312:434.
  7. Gao, X. et al. (2007) FEBS Lett. 581:5505.
  8. Lerch, T.F. et al. (2007) J. Biol. Chem. 282:15930.
  9. Schneyer, A.L. et al. (2004) J. Clin. Endocrinol. Metab. 89:5067.
  10. Lin, S-Y. et al. (2008) Mol. Endocrinol. 22:415.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu, Mu
Applications: WB, IHC, IHC-P
Species: Hu, Mu, Rt, Ca, Eq
Species: Hu, Mu, Rt, Po, Sh
Applications: WB, ICC/IF, IHC, IHC-P, PEP-ELISA
Species: Hu, Mu, Rt, Ze
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Po, Bv, Rb
Applications: WB, Flow, ICC/IF, IHC-Fr, IHC-P
Species: Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P

Publications for Follistatin (5836-FS)(5)

We have publications tested in 2 confirmed species: Human, Chicken.

We have publications tested in 1 application: Bioassay.

Filter By Application
All Applications
Filter By Species
All Species

Reviews for Follistatin (5836-FS) (0)

There are no reviews for Follistatin (5836-FS). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for Follistatin (5836-FS) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional Array Products

Bioinformatics Tool for Follistatin (5836-FS)

Discover related pathways, diseases and genes to Follistatin (5836-FS). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Follistatin (5836-FS)

Discover more about diseases related to Follistatin (5836-FS).

Pathways for Follistatin (5836-FS)

View related products by pathway.

PTMs for Follistatin (5836-FS)

Learn more about PTMs related to Follistatin (5836-FS).

Blogs on Follistatin

There are no specific blogs for Follistatin, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Recombinant Human Follistatin 288 (FS-288) Protein and receive a gift card or discount.


Gene Symbol FST