PXR/NR1I2 Antibody

Western Blot: PXR/NR1I2 Antibody [H00008856-B01P] - Analysis of NR1I2 expression in rat liver.

Immunocytochemistry/Immunofluorescence: PXR/NR1I2 Antibody [H00008856-B01P] - Analysis of purified antibody to NR1I2 on HepG2 cell. (antibody concentration 10 ug/ml)

Western Blot: PXR/NR1I2 Antibody [H00008856-B01P] - Analysis of NR1I2 expression in transfected 293T cell line by NR1I2 polyclonal antibody. Lane 1: NR1I2 transfected lysate(47.74 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

PXR/NR1I2 Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: NR1I2 (NP_003880.3, 1 a.a. - 434 a.a.) full-length human protein. MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: NR1I2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: It has been used for IF and WB.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for PXR/NR1I2 Antibody

• BXR
• NR1I2
• nuclear receptor subfamily 1 group I member 2
• nuclear receptor subfamily 1, group I, member 2
• ONR1
• Orphan nuclear receptor PAR1
• Orphan nuclear receptor PXR
• PAR
• PAR1
• PAR2
• Pregnane X receptor
• PRR
• PXR
• PXRPARq
• SAR
• Steroid and xenobiotic receptor
• SXR
• SXRBXR

Background

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NR1I2
• Uniprot:
  • NP_003880.3(Human)