PXR/NR1I2 Products

Description

NR1I2 product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Bioinformatics

Uniprot	AAH17304 Human NM_003889 Human NP_003880.3 Human NP_071285 Human O75469 Human
Product By Gene ID	8856
Alternate Names	nuclear receptor subfamily 1 group I member 2 nuclear receptor subfamily 1, group I, member 2 ONR1 Orphan nuclear receptor PAR1 Orphan nuclear receptor PXR PAR PAR1 PAR2 Pregnane X receptor PRR PXRPARq SAR Steroid and xenobiotic receptor SXRBXR

Research Areas for PXR/NR1I2

Find related products by research area and learn more about each of the different research areas below.

Stem Cell Markers
Transcription Factors and Regulators