PXR/NR1I2 Products

Antibodies
PXR/NR1I2 Antibody (H4417) [U ...
PXR/NR1I2 Antibody (H4417) [Unconj...
PP-H4417-00
Species: Hu
Applications: WB, IP, DirELISA
Host: Mouse Monoclonal
PXR/NR1I2 Antibody (H0502) [U ...
PXR/NR1I2 Antibody (H0502) [Unconj...
PP-H0502-00
Species: Hu
Applications: WB, DirELISA
Host: Mouse Monoclonal
PXR/NR1I2 Antibody
PXR/NR1I2 Antibody
H00008856-B01P
Species: Hu, Rt
Applications: WB, ELISA, ICC/IF
Host: Mouse Polyclonal
Antibody Pairs
PXR/NR1I2 Antibody Pair
PXR/NR1I2 Antibody Pair
H00008856-PW1
Species: Hu
Applications: WB, IP
Lysates
PXR/NR1I2 Overexpression Lysa ...
PXR/NR1I2 Overexpression Lysate (D...
H00008856-T01
Species: Hu
Applications: WB
PXR/NR1I2 Overexpression Lysa ...
PXR/NR1I2 Overexpression Lysate (N...
NBL1-13770
Applications: WB
Proteins
PXR/NR1I2 Recombinant Protein ...
PXR/NR1I2 Recombinant Protein
H00008856-P01
Species: Hu
Applications: WB, ELISA, PA
PXR/NR1I2 Partial Recombinant ...
PXR/NR1I2 Partial Recombinant Protein
H00008856-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
PXR/NR1I2 RNAi
PXR/NR1I2 RNAi
H00008856-R02
Species: Hu
PXR/NR1I2 RNAi
PXR/NR1I2 RNAi
H00008856-R03
Species: Hu
PXR/NR1I2 RNAi
PXR/NR1I2 RNAi
H00008856-R01
Species: Hu

Description

NR1I2 product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Product By Gene ID 8856
Alternate Names
  • nuclear receptor subfamily 1 group I member 2
  • Pregnane X receptor
  • SAR
  • Orphan nuclear receptor PXR
  • PRR
  • Orphan nuclear receptor PAR1
  • PAR1
  • PAR2
  • PAR
  • ONR1
  • SXRBXR
  • PXRPARq
  • Steroid and xenobiotic receptor
  • nuclear receptor subfamily 1, group I, member 2

Research Areas for PXR/NR1I2

Find related products by research area and learn more about each of the different research areas below.

Stem Cell Markers
Transcription Factors and Regulators

PTMs for PXR/NR1I2

Learn more about PTMs related to PXR/NR1I2.

Phosphorylation
Methylation
Demethylation
Hydroxylation

Bioinformatics Tool for PXR/NR1I2

Discover related pathways, diseases and genes to PXR/NR1I2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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