PAR1/Thrombin Receptor Antibody (N2-11)


Orthogonal Strategies: Immunohistochemistry: PAR1/Thrombin Receptor Antibody (N2-11) [NBP1-71770] - PAR1 is expressed by neural stem cells in the sub-ventricular zone (SVZ) of the adult mouse brain. more
Western Blot: PAR1/Thrombin Receptor Antibody (N2-11) [NBP1-71770] - Analysis of Thrombin Receptor expression in human testis using NBP1-71770.
Orthogonal Strategies: Immunohistochemistry: PAR1/Thrombin Receptor Antibody (N2-11) [NBP1-71770] - PAR1 is expressed by neural stem cells in the sub-ventricular zone (SVZ) of the adult mouse brain. more
Immunocytochemistry/ Immunofluorescence: PAR1/Thrombin Receptor Antibody (N2-11) [NBP1-71770] - Thrombin Receptor antibody was tested in HeLa cells with FITC (green). Nuclei and actin were counterstained with DAPI more
Western Blot: PAR1/Thrombin Receptor Antibody (N2-11) [NBP1-71770] - Analysis of PAR1 in whole cell lysate of Neuro2A cell line using 4ug/ml concentration of PAR1 antibody (clone N2-11). The antibody detected a strong more
Immunohistochemistry: PAR1/Thrombin Receptor Antibody (N2-11) [NBP1-71770] - Analysis of Thrombin Receptor on mouse skin using NBP1-71770.

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, ICC/IF
1 mg/ml
Validated by:

Orthogonal Strategies


Order Details

PAR1/Thrombin Receptor Antibody (N2-11) Summary

The oligopeptide CNATLDPRSFLL from human Thrombin Receptor. [Swiss-Prot# P25116]
Cell membrane; Multi-pass membrane protein.
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • ELISA 1:100 - 1:2000
  • Immunocytochemistry/Immunofluorescence 1:50
  • Immunofluorescence
  • Immunohistochemistry 1:100. Use reported in scientific literature (PMID 35055169)
  • Immunohistochemistry-Frozen reported in scientific literature (PMID 31885791)
  • Immunohistochemistry-Paraffin 1:100
  • Western Blot 1:1000
Theoretical MW
52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publications using
NBP1-71770 in the following applications:

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Tris-Glycine and 0.15M NaCl
0.05% Sodium Azide
1 mg/ml
Protein G purified

Alternate Names for PAR1/Thrombin Receptor Antibody (N2-11)

  • Cf2r
  • coagulation factor II (thrombin) receptor
  • Coagulation factor II receptor
  • F2R
  • HTR
  • PAR1
  • PAR1PAR-1protease-activated receptor 1
  • Protease-Activated Receptor 1
  • Thrombin receptor
  • ThrR
  • TRproteinase-activated receptor 1


Thrombin, the main effector protease of coagulation cascade, is a most potent platelet activator and its actions on platelets are mediated by Thrombin Receptors (also called platelet protease-activated receptors, PARs), which are GPCR members of 7-transmembrane domain receptor superfamily. PARs subtypes includes: PAR-1, PAR-2, PAR-3, and PAR-4, and in addition to platelets, they are also located in smooth muscle cells, endothelial cells, and fibroblasts. PAR1 or thrombin receptor (F2R) is a prototypical GPCR activated by thrombin's lowest concentration compared to other PARs and after cleavage of the extreme N-terminal peptide, the exposed tethered ligand of PAR1 activates itself for participation in diverse physiological processes including coagulation, inflammation, and vascular homeostasis. PAR1 knockout in mouse leads to death of pups in midgestation due to impaired vascular development as well as severe bleeding, whereas endothelial cell-specific reintroduction of PAR1 can rescue the phenotype. PAR1 has emerged as a target for anti-platelet therapies which are useful for ACS (acute coronary syndromes), stable coronary disease, ischemic atherothrombotic stroke, and peripheral arterial disease.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PAR1/Thrombin Receptor Antibody (NBP1-71770)(9)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 6 applications: ICC/IF, IF, IF/IHC, IHC-Fr, IHC-P, WB.

Filter By Application
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Showing Publications 1 - 9 of 9.
Publications using NBP1-71770 Applications Species
Hayashi Y, Shimizu I, Yoshida Y et al. Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity iScience 2022-07-15 [PMID: 35754738] (IHC-P, Mouse) IHC-P Mouse
Goldberg Z, Sher I, Qassim L et al. Intrinsic Expression of Coagulation Factors and Protease Activated Receptor 1 (PAR1) in Photoreceptors and Inner Retinal Layers International journal of molecular sciences 2022-01-17 [PMID: 35055169] (WB, IF, Mouse) WB, IF Mouse
Chen R, Cao X, et al. Dabigatran Suppresses PAR-1/SphK/S1P Activation of Astrocytes in Experimental Autoimmune Encephalomyelitis Model. Front Mol Neurosci 2020-07-23 [PMID: 32694981]
Nishimura F, Mogami H, Moriuchi K et al. Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone PLoS ONE 2020-05-04 [PMID: 32365105] (IHC-P, Human) IHC-P Human
Kim MJ, Park KH, Lee JY et al. Weisheng-Tang Ameliorates Acute Ischemic Brain Damage in Mice by Maintaining Blood-Brain Barrier Integrity Oxid Med Cell Longev 2019-12-03 [PMID: 31885791] (IHC-Fr, Mouse) IHC-Fr Mouse
Komori M, Ago T, Wakisaka Y, et al. Early initiation of a factor Xa inhibitor can attenuate tissue repair and neurorestoration after middle cerebral artery occlusion Brain Res. 2019-05-16 [PMID: 31103522] (IF/IHC, Mouse) IF/IHC Mouse
Choi CI, Yoon H, Drucker KL et al. The Thrombin Receptor Restricts Subventricular Zone Neural Stem Cell Expansion and Differentiation Sci Rep 2018-06-19 [PMID: 29921916] (IF/IHC, ICC/IF, Mouse) IF/IHC, ICC/IF Mouse
Kim HN, Kim YR, Ahn SM et al. Protease activated receptor-1 antagonist ameliorates the clinical symptoms of experimental autoimmune encephalomyelitis via inhibiting breakdown of blood brain barrier. J. Neurochem. 2015-08-18 [PMID: 26285165] (WB, Mouse) WB Mouse
Gonda K, Watanabe TM, Ohuchi N, Higuchi H. In vivo nano-imaging of membrane dynamics in metastatic tumor cells using quantum dots. J Biol Chem;285(4):2750-7. 2010-01-22 [PMID: 19917603] (ICC/IF, Mouse) ICC/IF Mouse

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for PAR1/Thrombin Receptor Antibody (NBP1-71770). (Showing 1 - 1 of 1 FAQs).

  1. Would you be able to confirm whether or not the peptide immunogen used to generate NBP1-71770 - PAR1/Thrombin Receptor Antibody (N2-11) is available for purchase?
    • Unfortunately for NBP1-71770, this product is a licensed monoclonal and we do not have authority to provide the immunizing peptide for purchase.

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Gene Symbol F2R