POT1 Antibody (S06-9I1)

Western Blot: POT1 Antibody (S06-9I1) [NBP3-15080] - Western blot detection of POT1 in K562, C6, 3T3 cell lysates using POT1 Rabbit mAb (1:1000 diluted). Predicted band size: 71kDa. Observed band size: 71kDa.

• Reactivity: Hu
• Applications: WB
• Clone: S06-9I1
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

POT1 Antibody (S06-9I1) Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthetic peptide of human POT1 (Uniprot#: Q9NUX5)
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: POT1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1/1000-1/5000
• Theoretical MW: 71 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA
• Preservative: 0.01% Sodium Azide
• Purity: Affinity purified

Alternate Names for POT1 Antibody (S06-9I1)

• DKFZp586D211
• HPOT1
• POT1 protection of telomeres 1 homolog
• POT1
• POT1-like telomere end-binding protein
• protection of telomeres 1 homolog (S. pombe)
• protection of telomeres protein 1

Background

POT1 (protection of telomeres 1), a telomere regulator, is a single-stranded telomeric DNA-binding protein that controls telomerase-mediated telomere elongation. Telomere maintenance is required for protection against changes in telomere length, which has been implicated in ageing and certain cancers. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Excessive transcriptional expression of POT1 has been associated with stomach cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: POT1